Correlation between heart type fatty acid binding protein and mild & severe COVID-19

doi:10.3969/j.issn.1004-583X.2022.12.007

Abstract

Abstract:

Objective To analyze the clinical characteristics of patients with mild & severe corona virus disease 2019 (COVID-19) and explore the correlation between herart fatty acid binding protein(H-FABP)and mild & severe COVID-19. Methods Totally 40 patients with negative expression of high-sensitivity troponin T (hs-cTnT) admitted to the Chongqing University Three Gorges Hospital before June 2022 were retrospectively analyzed. According to the diagnostic criteria of “Diagnosis and Treatment Protocol for COVID-19 (Trial Version 8)”, the patients were enrolled into the mild and severe groups. The expression levels of H-FABP in peripheral blood were compared between the two groups. Results Eligible 40 COVID-19 patients representing 20 cases in the mild group and 20 cases in the severe group were included. Compared with the mild group, the patients in the severe group were older ([41.9±10.5] vs [58.2±16.3]) years, and the proportion of patients with diabetes was higher (all P<0.05). H-FABP level in the severe group was significantly higher than that in the mild group ([3.97±1.80] vs [6.88±3.90] μg/L; [P<0.05], respectively). Conclusion In COVID-19 patients with negative hs-cTnT expression, serum H-FABP expression level is associated with the severity of COVID-19 disease. H-FABP may serve as a more sensitive and independent myocardial injury factor to contribute to the disease typing of COVID-19.

Key words: corona virus disease 2019, herart fatty acid binding protein, the severity of COVID-19 disease

CLC Number:

R563.1

Guo Wenxiu, Wang Hailong, Wang Doudou. Correlation between heart type fatty acid binding protein and mild & severe COVID-19[J]. Clinical Focus, 2022, 37(12): 1104-1107.

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URL: http://www.lchc.cn/EN/10.3969/j.issn.1004-583X.2022.12.007

http://www.lchc.cn/EN/Y2022/V37/I12/1104

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References 17

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项目	轻症 (n=20)	重症 (n=20)	t/ χ²值	P值
年龄(岁)	41.9±10.5	58.2±16.3	-3.769	0.001
性别[例(%)]
男女	14(70.0) 6(30.0)	10(50.0) 10(50.0)	1.667	0.197
吸烟[例(%)]	2(10.0)	1(5.0)	0	1.000
临床病史[例(%)]
糖尿病	0(0)	7(17.5)	6.234	0.013
高血压病	2(10.0)	1(5.0)	0	1.000
心血管疾病	0(0)	2(10.0)	0.526	0.468
慢性阻塞性肺疾病 [例(%)]	1(5.0)	2(10.0)	0	1.000
慢性肝病	1(5.0)	1(5.0)	0	1.000
慢性肾病	0(0)	0(0)	-	-
恶性肿瘤	0(0)	0(0)	-	-

项目	轻症 (n=20)	重症 (n=20)	t/ χ²值	P值
年龄(岁)	41.9±10.5	58.2±16.3	-3.769	0.001
性别[例(%)]
男女	14(70.0) 6(30.0)	10(50.0) 10(50.0)	1.667	0.197
吸烟[例(%)]	2(10.0)	1(5.0)	0	1.000
临床病史[例(%)]
糖尿病	0(0)	7(17.5)	6.234	0.013
高血压病	2(10.0)	1(5.0)	0	1.000
心血管疾病	0(0)	2(10.0)	0.526	0.468
慢性阻塞性肺疾病 [例(%)]	1(5.0)	2(10.0)	0	1.000
慢性肝病	1(5.0)	1(5.0)	0	1.000
慢性肾病	0(0)	0(0)	-	-
恶性肿瘤	0(0)	0(0)	-	-

组别	例数	H-FABP
轻型组	20	3.97±1.80
重型组	20	6.88±3.90
t值		-3.037
P值		0.005

组别	例数	H-FABP
轻型组	20	3.97±1.80
重型组	20	6.88±3.90
t值		-3.037
P值		0.005