Correlation between serum lipoprotein-associated phospholipase A2 level and the severity and prognosis of acute ischemic stroke

doi:10.3969/j.issn.1004-583X.2023.04.004

Abstract

Abstract:

Objective To explore the correlation between serum lipoprotein-associated phospholipase A2 (Lp-PLA2) level and the severity and prognosis of acute ischemic stroke (AIS). Methods From April 21, 2021 to April 21, 2022, forty-nine healthy volunteers receiving physical examination in our hospital were selected as the control group, and 49 patients with AIS were selected as the observation group. On admission, serum Lp-PLA2 level was detected by enzyme-linked immunosorbent assay (ELISA), and the severity of the disease was assessed by the National Institutes of Health Stroke Scale (NIHSS). Three months after discharge, the Modified Rankin Scale (mRS) was used to evaluate the prognosis, and the correlation between serum Lp-PLA2 level and the severity of disease was analyzed. Risk factors affecting the prognosis of AIS were identified. Results (1) There were no significant differences in drinking history, smoking history, disease history and body mass index (BMI) between the observation group and the control group (P>0.05). Serum Lp-PLA2 level in the observation group was significantly higher than that in the control group (P<0.05). (2) Among 49 patients with AIS, there were 19 mild cases, 16 moderate cases and 14 severe cases. There were significant differences in serum Lp-PLA2 levels and NIHSS score among them (P<0.05). (3) Among 49 patients with AIS, thirty-five patients had good prognosis and 14 had poor prognosis. There was no significant difference in the TOAST (Trial of Org 10172 in Acute Stroke Treatment) classification between patients with good prognosis and poor prognosis (P>0.05). Patients with good prognosis had a significantly shorter period from onset to hospitalization, and significantly lower serum Lp-PLA2 level than those with poor prognosis (both P<0.05). (4) Multivariable logistic regression analysis showed that age and serum Lp-PLA2 level were the main factors affecting the prognosis of AIS (P<0.05). Conclusion In patients with AIS, a high serum Lp-PLA2 level indicates a poor condition, which is a risk factor for the prognosis of AIS.

Key words: ischemic stroke, phospholipases A2, prognosis

CLC Number:

R743.3

He Xiangyu, Pan Yan, Zhang Xiaolin. Correlation between serum lipoprotein-associated phospholipase A2 level and the severity and prognosis of acute ischemic stroke[J]. Clinical Focus, 2023, 38(4): 315-318.

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URL: http://www.lchc.cn/EN/10.3969/j.issn.1004-583X.2023.04.004

http://www.lchc.cn/EN/Y2023/V38/I4/315

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References 20

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组别	例数	体重指数 ($\bar{x} \pm s$,kg/m²)	饮酒史 [例(%)]	吸烟史 [例(%)]	高血压 [例(%)]	疾病史[例(%)]		Lp-PLA2 ($\bar{x} \pm s$,μg/L)
组别	例数	体重指数 ($\bar{x} \pm s$,kg/m²)	饮酒史 [例(%)]	吸烟史 [例(%)]	高血压 [例(%)]	糖尿病	冠心病	Lp-PLA2 ($\bar{x} \pm s$,μg/L)
对照组	49	27.18±2.23	14(28.57)	22(44.90)	11(22.45)	13(26.53)	14(28.57)	425.73±158.31
观察组	49	27.62±2.47	15(30.61)	21(42.86)	10(20.41)	12(24.49)	15(30.61)	190.35±69.26
t/χ²值		1.121	0.123	0.214	0.139	0.901	0.101	12.53
P值		0.123	0.714	0.735	0.812	0.178	0.217	<0.01

组别	例数	体重指数 ($\bar{x} \pm s$,kg/m²)	饮酒史 [例(%)]	吸烟史 [例(%)]	高血压 [例(%)]	疾病史[例(%)]		Lp-PLA2 ($\bar{x} \pm s$,μg/L)
组别	例数	体重指数 ($\bar{x} \pm s$,kg/m²)	饮酒史 [例(%)]	吸烟史 [例(%)]	高血压 [例(%)]	糖尿病	冠心病	Lp-PLA2 ($\bar{x} \pm s$,μg/L)
对照组	49	27.18±2.23	14(28.57)	22(44.90)	11(22.45)	13(26.53)	14(28.57)	425.73±158.31
观察组	49	27.62±2.47	15(30.61)	21(42.86)	10(20.41)	12(24.49)	15(30.61)	190.35±69.26
t/χ²值		1.121	0.123	0.214	0.139	0.901	0.101	12.53
P值		0.123	0.714	0.735	0.812	0.178	0.217	<0.01

病情程度	例数	Lp-PLA2水平 ($\bar{x} \pm s$,μg/L)	NIHSS ($\bar{x} \pm s$,分)
轻度	19	310.47±90.68	4.93±1.40
中度	16	412.87±122.14	9.65±1.48
重度	14	582.08±143.20	16.89±1.52
F值		23.015	2.146
P值		0.000	0.000

病情程度	例数	Lp-PLA2水平 ($\bar{x} \pm s$,μg/L)	NIHSS ($\bar{x} \pm s$,分)
轻度	19	310.47±90.68	4.93±1.40
中度	16	412.87±122.14	9.65±1.48
重度	14	582.08±143.20	16.89±1.52
F值		23.015	2.146
P值		0.000	0.000

组别	例数	发病到住院的时间 ($\bar{x} \pm s$,h)	TOAST的分型[例(%)]					Lp-PLA2 ($\bar{x} \pm s$,μg/L)
组别	例数	发病到住院的时间 ($\bar{x} \pm s$,h)	CE	SAA	LAA	SUE	SOE	Lp-PLA2 ($\bar{x} \pm s$,μg/L)
预后良好	35	4.83±2.29	7(20.00)	11(31.43)	10(28.57)	3(8.57)	4(11.43)	346.27±104.51
预后不良	14	7.76±2.83	3(21.43)	4(28.57)	4(28.57)	1(7.14)	2(14.29)	589.76±152.32
t/χ²值		2.870	0.010	0.03	0.384	1.436	0.452	11.561
P值		0.004	0.822	0.786	0.384	0.311	0.539	<0.001