Correlation of JP2 with atrial fibrillation in patients with essential hypertension

doi:10.3969/j.issn.1004-583X.2025.06.004

Abstract

Abstract:

Objective To investigate the correlation between junctophilin 2 (JP2) and atrial fibrillation (AF) in patients with essential hypertension (EH). Methods A total of 127 EH patients hospitalized in the Department of Cardiology, Hebei General Hospital from 2019 to 2022 were selected. They were divided into the EH + AF group (n=52) and EH group (n=75) according to whether they were complicated with AF. The clinical data of the two groups were compared. Logistic regression was used to analyze the risk factors of AF in EF patients. The value of JP2 and left atrial diameter (LAD) in predicting AF in EH patients was evaluated by the receiver operating characteristic (ROC) curve. Results Compared with the EH group, patients in the EH+AF group had significantly older age, higher N-terminal B-type natriuretic peptide (NT-proBNP), LAD and left ventricular end-systolic diameter (LVESD), but lower estimated glomerular filtration rate (eGFR), JP2 and left ventricular ejection fraction (LVEF) (P<0.05). Univariate logistic regression analysis showed that age, NT-proBNP, LAD and LVEDD were risk factors for AF in EH patients, while eGFR, JP2 and LVEF were protective factors for AF in EH patients (P<0.05). Multivariate logistic regression analysis showed that LAD was an independent risk factor for AF in EH patients, and JP2 was an independent protective factor for AF in EH patients (P<0.05). The ROC curve showed that the area under the curve (AUC) of JP2 in identifying AF in EH patients was 0.825 (95%CI: 0.753-0.897, P<0.001), with a sensitivity of 92.3%, and a specificity of 68.5%. The AUC of LAD in identifying AF in EH patients was 0.805(95%CI: 0.724-0.886, P<0.001), with a sensitivity of 80.8%, and a specificity of 67.1%. The AUC of JP2 combined with LAD in identifying AF in EH patients was 0.918(95%CI: 0.871-0.964, P<0.001), with a sensitivity of 86.5%, and a specificity of 84.9%. Conclusion Decreased JP2 in EH patients is related to the enlargement of LAD and AF, and the combination of JP2 and LAD can better predict AF in EH patients.

Key words: essential hypertension, atrial fibrillation, junctophilin-2, left atrial diameter

CLC Number:

R544.1

Si Huili, Guo Shuang, Dong Haocheng, Li Shuren. Correlation of JP2 with atrial fibrillation in patients with essential hypertension[J]. Clinical Focus, 2025, 40(6): 504-508.

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URL: http://www.lchc.cn/EN/10.3969/j.issn.1004-583X.2025.06.004

http://www.lchc.cn/EN/Y2025/V40/I6/504

Figures/Tables 4

References 25

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项目	EH+AF组(n=52)	EH组(n=75)	χ²/t/Z值	P值
年龄(岁)	70.1±11.3	64.2±12.4	-3.042	0.003
女性[例(%)]	27(51.9)	40(53.3)	0.025	0.876
BMI(kg/m²)	26.2(4.6)	26.0(4.4)	-0.691	0.489
饮酒史[例(%)]	12(23.1)	10(13.3)	2.036	0.154
吸烟史[例(%)]	15(28.8)	14(18.7)	1.806	0.179
糖尿病史[例(%)]	12(23.1)	28(37.3)	2.893	0.089
冠心病史[例(%)]	24(46.2)	40(53.3)	0.633	0.426
空腹血糖(mmol/L)	5.4(1.0)	5.1(1.6)	-1.897	0.058
尿酸(μmol/L)	333.8(102.0)	310.9(111.4)	-1.657	0.097
LDL-C(mmol/L)	2.3(1.2)	2.7(1.0)	-1.630	0.103
eGFR(ml/min)	80.4(23.3)	91.4(14.5)	-3.731	<0.001
WBC(×10⁹/L)	6.4(2.4)	6.1(2.3)	-0.613	0.540
HB(g/L)	135.3±17.8	134.6±16.2	0.220	0.826
NT-proBNP (ng/L)	278.0(720.0)	71.0(69.0)	-5.334	<0.001
JP2 (ng/L)	43.8(11.0)	60.3(24.3)	-6.306	<0.001
LAD (mm)	44(7)	38(5)	-5.812	<0.001
LVESD (mm)	31.0(4.0)	29.5(5.0)	-2.635	0.008
LVEDD (mm)	47.0(7.0)	46.5(5.0)	-1.367	0.171
LVEF (%)	62.0(5.0)	65.0(6.8)	-2.785	0.005

项目	EH+AF组(n=52)	EH组(n=75)	χ²/t/Z值	P值
年龄(岁)	70.1±11.3	64.2±12.4	-3.042	0.003
女性[例(%)]	27(51.9)	40(53.3)	0.025	0.876
BMI(kg/m²)	26.2(4.6)	26.0(4.4)	-0.691	0.489
饮酒史[例(%)]	12(23.1)	10(13.3)	2.036	0.154
吸烟史[例(%)]	15(28.8)	14(18.7)	1.806	0.179
糖尿病史[例(%)]	12(23.1)	28(37.3)	2.893	0.089
冠心病史[例(%)]	24(46.2)	40(53.3)	0.633	0.426
空腹血糖(mmol/L)	5.4(1.0)	5.1(1.6)	-1.897	0.058
尿酸(μmol/L)	333.8(102.0)	310.9(111.4)	-1.657	0.097
LDL-C(mmol/L)	2.3(1.2)	2.7(1.0)	-1.630	0.103
eGFR(ml/min)	80.4(23.3)	91.4(14.5)	-3.731	<0.001
WBC(×10⁹/L)	6.4(2.4)	6.1(2.3)	-0.613	0.540
HB(g/L)	135.3±17.8	134.6±16.2	0.220	0.826
NT-proBNP (ng/L)	278.0(720.0)	71.0(69.0)	-5.334	<0.001
JP2 (ng/L)	43.8(11.0)	60.3(24.3)	-6.306	<0.001
LAD (mm)	44(7)	38(5)	-5.812	<0.001
LVESD (mm)	31.0(4.0)	29.5(5.0)	-2.635	0.008
LVEDD (mm)	47.0(7.0)	46.5(5.0)	-1.367	0.171
LVEF (%)	62.0(5.0)	65.0(6.8)	-2.785	0.005

自变量	单因素logistic回归分析			多因素logistic回归分析
自变量	OR值	95%CI	P值	OR值	95%CI	P值
年龄	1.048	1.015~1.082	0.004	0.989	0.937~1.044	0.685
eGFR	-0.959	0.936~0.983	0.001	-0.997	0.959~1.036	0.864
NT-proBNP	1.005	1.002~1.007	<0.001	1.002	0.999~1.005	0.179
JP2	-0.912	0.881~0.944	<0.001	-0.901	0.860~0.944	<0.001
LAD	1.300	1.173~1.441	<0.001	1.339	1.130~1.586	0.001
LVESD	1.155	1.039~1.284	0.008	0.957	0.778~1.177	0.676
LVEF	-0.906	0.843~0.974	0.007	-0.902	0.795~1.023	0.109

自变量	单因素logistic回归分析			多因素logistic回归分析
自变量	OR值	95%CI	P值	OR值	95%CI	P值
年龄	1.048	1.015~1.082	0.004	0.989	0.937~1.044	0.685
eGFR	-0.959	0.936~0.983	0.001	-0.997	0.959~1.036	0.864
NT-proBNP	1.005	1.002~1.007	<0.001	1.002	0.999~1.005	0.179
JP2	-0.912	0.881~0.944	<0.001	-0.901	0.860~0.944	<0.001
LAD	1.300	1.173~1.441	<0.001	1.339	1.130~1.586	0.001
LVESD	1.155	1.039~1.284	0.008	0.957	0.778~1.177	0.676
LVEF	-0.906	0.843~0.974	0.007	-0.902	0.795~1.023	0.109