Epidemiological characteristics of the main pathogens causing acute respiratory infections in a hospital in Chengdu from 2024 to 2025

doi:10.3969/j.issn.1004-583X.2025.07.004

Abstract

Abstract:

Objective To elucidate the distribution characteristics of respiratory pathogens in Chengdu City, and to provide a scientific basis for targeted regional prevention and clinical decision-making through systematic epidemiological analysis. Methods A total of 6, 795 cases meeting the diagnostic criteria for respiratory infections were collected from Chengdu Second People's Hospital between February 2024 and January 2025. Multiplex real-time quantitative PCR was employed to accurately detect six common respiratory pathogens: adenovirus (ADV), influenza A virus (FluA), influenza B virus (FluB), human rhinovirus (HRV), Mycoplasma pneumoniae (MP), and respiratory syncytial virus (RSV). Results The overall pathogen detection rate was 50.58%, with single-pathogen infections accounting for 44.06% and co-infections for 6.52%. Among single infections, HRV (17.29%) had the highest detection rate, followed by MP (13.89%) and ADV (12.91%). In co-infections, ADV combined with HRV was the predominant type. HRV was the only pathogen with a significant gender difference in the detection rate, showing a significantly higher detection rate in males than females (P<0.01). Detection rates varied by age and season, with the highest overall rate observed in the 1-18 age group. Pathogens exhibited seasonal “staggered peak” trends. Conclusion Respiratory infections in Chengdu are predominantly caused by single pathogens, with HRV being the most prevalent. The epidemiological characteristics of different pathogens are closely associated with age and season.

Key words: respiratory pathogens, acute respiratory infections, epidemiological characteristics

CLC Number:

R446.11+2

Fan Jiaxin, Xia Rujie, Zhou Xiaomei, Hu Chunxiao. Epidemiological characteristics of the main pathogens causing acute respiratory infections in a hospital in Chengdu from 2024 to 2025[J]. Clinical Focus, 2025, 40(7): 602-607.

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URL: http://www.lchc.cn/EN/10.3969/j.issn.1004-583X.2025.07.004

http://www.lchc.cn/EN/Y2025/V40/I7/602

Figures/Tables 6

References 41

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呼吸道病原体	阳性频次	检出率(%)	构成比(%)
ADV	877	12.91	22.48
FluA	409	6.02	10.48
HRV	1175	17.29	30.12
FluB	97	1.43	2.49
RSV	399	5.87	10.23
MP	944	13.89	24.20
总阳性例数	3437	50.58	22.48
χ²值		1429.49
P值		<0.01

呼吸道病原体	阳性频次	检出率(%)	构成比(%)
ADV	877	12.91	22.48
FluA	409	6.02	10.48
HRV	1175	17.29	30.12
FluB	97	1.43	2.49
RSV	399	5.87	10.23
MP	944	13.89	24.20
总阳性例数	3437	50.58	22.48
χ²值		1429.49
P值		<0.01

性别	样本总量	ADV	FluA	HRV	FluB	RSV	MP	总检出率
男	3664(53.92)	483(7.11)	209(3.08)	689(10.14)	55(0.81)	230(3.38)	482(7.09)	1875(51.17)
女	3131(46.08)	394(5.8)	200(2.94)	486(7.15)	42(0.62)	169(2.49)	462(6.8)	1559(49.79)
χ²值		0.54	1.40	12.72	0.31	2.36	3.62	1.288
P值		0.463	0.238	<0.01	0.580	0.124	0.057	0.256

性别	样本总量	ADV	FluA	HRV	FluB	RSV	MP	总检出率
男	3664(53.92)	483(7.11)	209(3.08)	689(10.14)	55(0.81)	230(3.38)	482(7.09)	1875(51.17)
女	3131(46.08)	394(5.8)	200(2.94)	486(7.15)	42(0.62)	169(2.49)	462(6.8)	1559(49.79)
χ²值		0.54	1.40	12.72	0.31	2.36	3.62	1.288
P值		0.463	0.238	<0.01	0.580	0.124	0.057	0.256

年龄(岁)	样本总量	ADV	FluA	HRV	FluB	RSV	MP	总检出率
<1	898	29(3.23)	22(2.45)	23(2.56)	24(2.67)	25(2.78)	26(2.90)	149(16.59)
1~18	4500	800(17.78)	235(5.22)	930(20.67)	55(1.22)	279(6.20)	875(19.44)	3174(70.53)
19~60	603	29(4.81)	72(11.94)	38(6.30)	23(3.81)	11(1.82)	29(4.81)	202(33.50)
>60	794	19(2.39)	80(10.08)	33(4.16)	4(0.50)	9(1.13)	7(0.88)	152(19.14)
χ²值		283.07	80.12	332.88	31.44	56.17	360.44	1624.16
P值		<0.01	<0.01	<0.01	<0.01	<0.01	<0.01	<0.01