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Guidelines for Diagnosis and Treatment of Chronic Gastritis in China (2022, Shanghai): An interpretation Wu Haotian, Fan Yuwen, Zhang Xiaolan Clinical Focus    2023, 38 (10): 926-930.   DOI: 10.3969/j.issn.1004-583X.2023.10.012 Abstract （696）   HTML （32）    PDF（pc） （843KB）（2252）       Knowledge map    Save In 2022, the Chinese Society of Gastroenterology has referred the research and guidelines associated with chronic gastritis at home and abroad in recent years, formulated a total of 53 recommendations on the epidemiology, clinical manifestations, endoscopic and laboratory diagnosis, treatment principles, outcomes and prognosis, and unsolved problems at home and abroad, and published the Guidelines for Diagnosis and Treatment of Chronic Gastritis in China (2022, Shanghai). This article interprets the updates and highlights of this guideline. Table and Figures | Reference | Related Articles | Metrics | Comments（0）

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Clinical Focus    2023, 38 (8): 743-748.   DOI: 10.3969/j.issn.1004-583X.2023.08.012 Abstract （257）   HTML （2）    PDF（pc） （896KB）（922）       Knowledge map    Save Reference | Related Articles | Metrics | Comments（0）

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Clinical Focus    2023, 38 (12): 1146-1149.   DOI: 10.3969/j.issn.1004-583X.2023.12.016 Abstract （174）   HTML （6）    PDF（pc） （875KB）（646）       Knowledge map    Save Reference | Related Articles | Metrics | Comments（0）

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Effects of dual coping intervention on coping ability and marital adjustment of young adult patients with breast cancer and their spouses Gu Jiahua, Wu Qi Clinical Focus    2022, 37 (9): 822-826.   DOI: 10.3969/j.issn.1004-583X.2022.09.011 Abstract （715）   HTML （1）    PDF（pc） （855KB）（627）       Knowledge map    Save Objective To explore the effect of dual coping intervention on coping ability and marital adjustment of young adult patients with breast cancer and their spouses. Methods The young ault postoperative patients with breast cancer and their spouses (n=80 pairs), who visited the Department of Breast, the International Peace Maternity & Child Health Hospital of China welfare institute (June 2021 to September 2021) were randomized to recevie conventional care (control group, n=40 pairs) or dual coping intervention + conventional care (observation group, n=40 pairs) for 4 months, aiming to compare intergroup coping ability and marital adjustment.Results Before intervention, the two groups had insignificant differences in the total scores and dimension scores of the dyadic coping inventory (DCI) scale and Locke-Wollance marital adjustment scale (LWMAS) (all P>0.05); after intervention, the observation group had significantly higher total scores and dimension scores of DCI scale and LWMAS than the control group (all P<0.05).Conclusion Dual coping intervention can improve the coping ability and marital adjustment of young adult patients with breast cancer and their spouses, which contributes to the improvements in marital quality and happiness. Table and Figures | Reference | Related Articles | Metrics | Comments（0）

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Clinical Focus    2022, 37 (8): 748-752.   DOI: 10.3969/j.issn.1004-583X.2022.08.014 Abstract （535）   HTML （10）    PDF（pc） （884KB）（579）       Knowledge map    Save Table and Figures | Reference | Related Articles | Metrics | Comments（0）

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Clinical Focus    2024, 39 (2): 188-192.   DOI: 10.3969/j.issn.1004-583X.2024.02.018 Abstract （254）   HTML （9）    PDF（pc） （847KB）（356）       Knowledge map    Save Reference | Related Articles | Metrics | Comments（0）

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Long-term effect of hypoglossal nerve stimulation in the treatment of obstructive sleep apnea hypopnea syndrome: A meta analysis Sun Ying, Yu Qin Clinical Focus    2022, 37 (8): 677-684.   DOI: 10.3969/j.issn.1004-583X.2022.08.001 Abstract （426）   HTML （0）    PDF（pc） （2009KB）（268）       Knowledge map    Save Objective To explore the long-term effect of hypoglossal nerve stimulation (HGNS) in the treatment of obstructive sleep apnea hypopnea syndrome (OSAHS). Methods Through the systematic search of China knowledge Network database, Wanfang database, VIP database, Chinese biomedical literature database, Pubmed, Embase, Cochrane Library, the article published by domestic and foreign scholars regarding HGNS, untill to March 2022, were collected. The literatures were screened and extracted by two evaluators independently and the quality of the literatures was evaluated by NOS scale, Meta analysis was carried out by stata12.0 software. Results A total of 12 cohort studies with 776 patients were included. The posttreatment 6-month sleep apnea hypopnea index, (AHI, mean difference [SMD]=-1.47, 95% CI 95% confidence interval [95%CI]-1.68-1.25, P=0.000), oxygen desaturation index (ODI, SMD=-0.77,CI: -0.95--0.58, P=0.000), epworth scale score (ESS, SMD=-1.00, CI: -1.16--0.84, P=0.000), functional qutcomes of sleep questionnaire (FQSQ, SMD=1.10, CI: 0.92~1.28, P=0.000), AHI in 12 months after operation (SMD=-1.250, CI:-1.39--1.10, P=0.000), ODI (SMD=-0.874, CI:-1.114--0.634, P=0.001) and FQSQ (SMD=1.10, CI: 0.96-1.22, P=0.000) were significantly improved than those before treatment. Conclusion Hypoglossal nerve stimulation is effective in the treatment of OSAHS. Table and Figures | Reference | Related Articles | Metrics | Comments（0）

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Clinical Focus    2022, 37 (8): 759-763.   DOI: 10.3969/j.issn.1004-583X.2022.08.016 Abstract （304）   HTML （0）    PDF（pc） （898KB）（249）       Knowledge map    Save Reference | Related Articles | Metrics | Comments（0）

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Clinical Focus    2023, 38 (1): 88-92.   DOI: 10.3969/j.issn.1004-583X.2023.01.015 Abstract （397）   HTML （6）    PDF（pc） （857KB）（246）       Knowledge map    Save Reference | Related Articles | Metrics | Comments（0）

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Clinical Focus    2024, 39 (10): 935-939.   DOI: 10.3969/j.issn.1004-583X.2024.10.012 Abstract （131）   HTML （6）    PDF（pc） （803KB）（227）       Knowledge map    Save Reference | Related Articles | Metrics | Comments（0）

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Clinical Focus    2024, 39 (7): 654-657.   DOI: 10.3969/j.issn.1004-583X.2024.07.013 Abstract （222）   HTML （6）    PDF（pc） （853KB）（221）       Knowledge map    Save Table and Figures | Reference | Related Articles | Metrics | Comments（0）

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Clinical Focus    2025, 40 (4): 372-376.   DOI: 10.3969/j.issn.1004-583X.2025.04.014 Abstract （81）   HTML （3）    PDF（pc） （988KB）（205）       Knowledge map    Save Table and Figures | Reference | Related Articles | Metrics | Comments（0）

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A network meta-analysis of SGLT2 inhibitors on cardiovascular outcomes in patients with type 2 diabetes Wang Runqing, Wang Qian, Liao Jianxiong Clinical Focus    2022, 37 (12): 1061-1073.   DOI: 10.3969/j.issn.1004-583X.2022.12.001 Abstract （426）   HTML （3）    PDF（pc） （3529KB）（195）       Knowledge map    Save Objective Type 2 diabetes is a chronic disease and heart failure is a common complication of type 2 diabetes, and large studies have demonstrated the role of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in improving cardiovascular outcomes of patients with type 2 diabetes. In this paper, the efficacy effects of five different SGLT2i were indirectly compared by systematic evaluation. Methods PubMed, Web of science, Cochrane Library, CNKI, WanFang, and VIP databases were searched to collect relevant literature with a search time frame of build to July 2022. Two researchers independently screened the literature and extracted the corresponding data, using the composite outcome of heart failure hospitalization and cardiovascular death as the primary outcome indicator, with heart failure hospitalization, cardiovascular death and all-cause death as secondary outcome indicators, and a network meta-analysis was performed using Stata 16.0 as well as the network program package. Results A total of 340 publications were retrieved, eligible 11 publications representing 62 904 patients were included. The five intervention methods were involved, namely: empagliflozin, sotagliflozin, dapagliflozin, ertugliflozin and canagliflozin. There were no statistically significant differences (P>0.05) between the five different SGLT2i in altering the composite outcomes of heart failure hospitalization and cardiovascular death, cardiovascular death, heart failure hospitalization and all-cause death in patients with type 2 diabetes. All five different SGLT2i significantly improved heart failure hospitalization outcomes in patients with type 2 diabetes compared to placebo. There was a statistically significant difference between empagliflozin and sotagliflozin in improving the composite outcome of heart failure hospitalization and cardiovascular death. No significant difference between placebo and the five different SGLT2i in improving the outcome of cardiovascular death or all-cause death. Conclusion There was a trend towards a more significant benefit of empagliflozin and sotagliflozin improving the composite outcome of heart failure hospitalization and cardiovascular death and heart failure hospitalization outcome in type 2 diabetic patients, while for cardiovascular death or all-cause death outcome, there was no statistically significant difference between the five different SGLT2i and placebo, and the exact mechanisms and causes still need to be explored and validated in large studies. Table and Figures | Reference | Related Articles | Metrics | Comments（0）

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The risk prediction models for pneumonia in patients with intracerebral hemorrhage: A systematic review Liu Jinteng, Liu Xingyu, Huang Lumei, Pan Hailong Clinical Focus    2025, 40 (1): 5-13.   DOI: 10.3969/j.issn.1004-583X.2025.01.001 Abstract （133）   HTML （4）    PDF（pc） （976KB）（194）       Knowledge map    Save Objective To systematically analyze and evaluate the risk prediction model for pneumonia in patients with intracerebral hemorrhage (ICH). Methods Articles reporting risk prediction model for pneumonia in ICH patients published prior to February 2023 were searched in the online databases of Pubmed, Web of Science, Embase, The Cochrane Library, Scopus, Ovid Medline, CNKI (China National Knowledge Infrastructure), WanFang Data, VIP and CBM (Chinese Biomedical Literature Database). Two researchers were independently responsible for screening literature and extracting data. The quality of the literature included in this study was rigorously evaluated, and both the risk of bias and adaptability were assessed in accordance with the Transparent Reporting of a Multivariable Prediction Model for Individal Prognosis or Diagnosis(TRIPOD), and the Prediction Model Risk of Bias Assessment Tool(PROBAST). Results A total of 12 relevant studies were included, involving 7 registered studies, 1 ovarian case-control study, 3 single-center case-control studies, and 1 retrospective cohort study. Logistic regression and machine learning were used for modeling. Eight studies were validated internally, 2 studies were only validated externally, and 2 studies were validated both. The area under the receiver operating characteristic curve of the model was 0.740-0.920. The range of predictors in the 12 studies ranged from 4 to 11, and the common predictors were the age, the National Institutes of Health Stroke Scale score, the Glasgow Coma Scale score, dysphagia, smoking, chronic obstructive pulmonary disease, and nasogastric tube feeding. Model calibration was performed in 9 studies and not in 3 studies. The model was mainly presented in the form of risk score, risk calculation formula and nomogram. The included studies exhibited moderate quality and a high risk of bias. Conclusion The current model for predicting the risk of pneumonia in ICH patients demonstrates good predictive ability, and the predictive factors are relatively easy to obtain. However, there are also significant defects and high bias. In future research, it is recommended that researchers adhere to the TRIPOD guideline and PROBAST statement when conducting prediction model studies. It is important to summarize the advantages and disadvantages of existing models and to conduct external verification, thus developing a risk prediction model for pneumonia in ICH patients with excellent predictive performance and ease of use. Table and Figures | Reference | Related Articles | Metrics | Comments（0）

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Interpretation of the Chinese Expert Consensus on Gastrointestinal Endoscopic Treatment of Obesity Su Miao, Wang Sashuang, Zhao Dongqiang Clinical Focus    2025, 40 (4): 366-371.   DOI: 10.3969/j.issn.1004-583X.2025.04.013 Abstract （60）   HTML （1）    PDF（pc） （468KB）（187）       Knowledge map    Save Obesity is a chronic disease that increases the risk of cardiovascular and metabolic disorders. Current treatment methods for obesity mainly include lifestyle interventions, pharmacotherapy, and surgical procedures. Traditional lifestyle interventions result in a poor long-term compliance, and pharmacotherapy is often associated with side effects or weight regain. Although surgical procedures can lead to significant weight loss, they are limited by the invasiveness, high complication risks, and irreversibility. In recent years, endoscopic bariatric therapy has emerged as a safer and more effective treatment option due to its reversibility, minimal invasiveness, and cost-effectiveness. To standardize this approach in China, the National Clinical Medical Research Center for Digestive Diseases, in collaboration with experts in this field, developed the Chinese Expert Consensus on Gastrointestinal Endoscopic Treatment of Obesity. This article reviewed the key points of the consensus, aiming to enhance the understanding of endoscopic bariatric therapy among both healthcare providers and patients. The goal is to advance and refine endoscopic bariatric therapy while promoting academic exchange and expanding awareness of minimally invasive treatment options in China. Reference | Related Articles | Metrics | Comments（0）

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Interpretation for the third edition of WHO Operational Handbook on Tuberculosis, Module 6: Tuberculosis and Comorbidities Zeng Jian, Wang Xiaomin, Fang Mutong, Lu Shuihua Clinical Focus    2025, 40 (3): 270-274.   DOI: 10.3969/j.issn.1004-583X.2025.03.014 Abstract （74）   HTML （1）    PDF（pc） （871KB）（176）       Knowledge map    Save Tuberculosis (TB) is a major global public health challenge, and its interaction with a variety of comorbidities like mental disorder, HIV infection and diabetes significantly affects the prognosis of patients. In January 2025, the World Health Organization (WHO) released the third edition of the WHO Operational Handbook on Tuberculosis, Module 6: Tuberculosis and Comorbidities, which systematically integrated the management strategy of TB and comorbidities. Based on the three core comorbidities of mental and substance-use disorders, human immunodeficiency virus (HIV) infection and diabetes, this paper interprets the key recommendations for the operation manual including screening tools, comprehensive treatment approach, and preventive measures. it aims to provide evidence-based guidance for clinical practice and optimize the whole process management of TB patients. Reference | Related Articles | Metrics | Comments（0）

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Interpretation of the Guidelines for the Assessment and Clinical Practice of Behavioral and Psychological Symptoms of Dementia 2025 Gao Yan, Qu Shuo, Li Yang, Qiu Huiqing, He Sha, Ma Xiaowei Clinical Focus    2025, 40 (5): 389-393.   DOI: 10.3969/j.issn.1004-583X.2025.05.001 Abstract （76）   HTML （4）    PDF（pc） （826KB）（172）       Knowledge map    Save Currently, more than 55 million people suffer from dementia worldwide. Alzheimer's disease (AD) is the most common diagnostic cause of dementia, accounting for 50%-70% of all dementia cases. In March 2025, the Canadian Coalition for Seniors' Mental Health (CCSHM) released the Guidelines for the Assessment and Clinical Practice of Behavioral and Psychological Symptoms of Dementia 2025, targeting on the assessment and management of BPSD in AD patients. The present article focused on the five major symptoms of BPSD, including agitation, depression, anxiety, mental symptoms and potential risk sexual behavior manifestations, as well as the the reduction of antipsychotics and psychotropic drugs. Through interpreting key suggestions in the guideline, three aspects of diagnostic criteria, evaluation methods and treatment measures were discussed to provide references for clinical treatment of BPSD and optimizing the whole-process management of BPSD symptoms in AD patients. Table and Figures | Reference | Related Articles | Metrics | Comments（0）

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Clinical Focus    2024, 39 (9): 842-846.   DOI: 10.3969/j.issn.1004-583X.2024.09.015 Abstract （249）   HTML （11）    PDF（pc） （905KB）（165）       Knowledge map    Save Table and Figures | Reference | Related Articles | Metrics | Comments（0）

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Clinical Focus    2022, 37 (8): 753-758.   DOI: 10.3969/j.issn.1004-583X.2022.08.015 Abstract （330）   HTML （3）    PDF（pc） （889KB）（164）       Knowledge map    Save Reference | Related Articles | Metrics | Comments（0）

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Clinical Focus    2023, 38 (11): 1034-1037.   DOI: 10.3969/j.issn.1004-583X.2023.11.014 Abstract （158）   HTML （3）    PDF（pc） （842KB）（154）       Knowledge map    Save Reference | Related Articles | Metrics | Comments（0）

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Clinical efficacy of individualized vestibular rehabilitation in the treatment of vestibular neuritis Zhang Xiuling, Zhang Li, Chen Jinxiang Clinical Focus    2025, 40 (3): 227-230.   DOI: 10.3969/j.issn.1004-583X.2025.03.006 Abstract （87）   HTML （2）    PDF（pc） （856KB）（154）       Knowledge map    Save Objective To investigate the clinical efficacy of individualized vestibular rehabilitation program in the treatment of vestibular neuritis. Methods Seventy-six patients with vestibular neuritis who visited the outpatient department from June 2020 to June 2023 were randomly divided into the control group and experimental group. Routine medication was given to patients of both groups. Based on physical examination, vestibular function examination, and subjective scale scores, the impairment of the vestibulo-ocular reflex (VOR) pathway and vestibular spinal reflex (VSR) pathway were assessed in patients of the experimental group, and thus managed by individualized vestibular rehabilitation plans. After three months of treatment, the various examination indicators and clinical treatment effects of the two groups were compared. Results The clinical indicators of both groups significantly improved compared to before treatment. Compared with those of the control group, patients in the experimental group had significantly better improvements in indicators such as Romberg test (ROM), directional preference (DP), video head impulse test (vHIT) gain, dizziness handicap inventory (DHI), and Berg balance scale (BBS) score (P<0.05). The clinical treatment effective was significantly higher in the experimental group than that of the control group (97.37% vs 81.57%, P<0.05). An individualized rehabilitation treatment provided a superior effective outcome to patients with VSR pathway damage. Conclusion Accurately developing individualized vestibular rehabilitation plans based on clinical examination results of patients with vestibular neuritis has significant effects and advantages in improving subjective scores, symptoms and signs, objective indicators of vestibular function. It is worth further promotion. Table and Figures | Reference | Related Articles | Metrics | Comments（0）

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Clinical Focus    2023, 38 (11): 1048-1052.   DOI: 10.3969/j.issn.1004-583X.2023.11.017 Abstract （110）   HTML （2）    PDF（pc） （864KB）（151）       Knowledge map    Save Reference | Related Articles | Metrics | Comments（0）

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Clinical Focus    2023, 38 (7): 668-672.   DOI: 10.3969/j.issn.1004-583X.2023.07.015 Abstract （222）   HTML （1）    PDF（pc） （848KB）（151）       Knowledge map    Save Reference | Related Articles | Metrics | Comments（0）

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Clinical application of GEMOX combined with target-immunity therapy in patients with advanced biliary tract cancer Wu Xiaomin, Fang Yipeng, Zhang Zhen, Zhang Ye, Jin Cheng Clinical Focus    2024, 39 (5): 408-412.   DOI: 10.3969/j.issn.1004-583X.2024.05.004 Abstract （296）   HTML （6）    PDF（pc） （1116KB）（150）       Knowledge map    Save Objective To evaluate the clinical efficacy and safety of gemcitabine and oxaliplatin (GEMOX) combined with target-immunity therapy (lenvatinib and programmed cell death 1 [PD-1] monoclonal antibody) in patients with advanced biliary tract cancer (BTC). Methods Twenty-four patients with advanced BTC received GEMOX combined with target-immunity therapy visited Integrative Oncology Department or Hepatobiliary Surgery Department of our hospital from January 2015 to January 2024 were recruited. The primary end points were set as overall survival (OS) and progression-free survival (PFS), and the secondary end points were objective response rate (ORR), disease control rate (DCR) and safety. The safety and overall clinical efficacy of GEMOX combined with target-immunity therapy regimen on advanced BTC were comprehensively evaluated via tumor marker indexes (carcinoembryonic antigen [CEA], carbohydrate antigen 125 [CA125], CA199), adverse reactions rates, quality of life scores, imaging indicators, and other data. Results None of the 24 patients had complete remission (CR). ORR was 33.3% (8/24, 8 patients had PR), DCR was 66.7% (16/24; 8 patients had SD and 8 patients had PD, respectively), median OS was 13 months and median PFS was 8 months. After treatment, the levels of CA199 were significantly lower than those before treatment (P<0.05). The incidence of adverse events in 24 patients were rash (14/24, 58.3%), leucopenia (22/24, 91.6%), anemia (20/24, 83.3%). One patient had serious adverse events and withdrew from treatment, one patient died of biliary obstruction with infection during treatment. Conclusion GEMOX combined with target-immunity therapy regimen is safe and effective in the treatment of advanced BTC, it may be used clinically. Table and Figures | Reference | Related Articles | Metrics | Comments（0）

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Clinical Focus    2025, 40 (6): 564-569.   DOI: 10.3969/j.issn.1004-583X.2025.06.015 Abstract （24）   HTML （1）    PDF（pc） （938KB）（149）       Knowledge map    Save Reference | Related Articles | Metrics | Comments（0）

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Clinical Focus    2022, 37 (10): 957-960.   DOI: 10.3969/j.issn.1004-583X.2022.10.016 Abstract （434）   HTML （2）    PDF（pc） （835KB）（148）       Knowledge map    Save Reference | Related Articles | Metrics | Comments（0）

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Longitudinal cohort study of oral health status and cognitive function in the elderly: A meta-analysis Wang Lin, Wang Ting, Pu Xiaolan, Ju Mei Clinical Focus    2024, 39 (8): 677-683.   DOI: 10.3969/j.issn.1004-583X.2024.08.001 Abstract （221）   HTML （7）    PDF（pc） （1364KB）（145）       Knowledge map    Save Objective To explore the correlation between oral health status and the risk of cognitive dysfunction by meta-analysis. Methods Cohort studies on the correlation between oral health status and cognitive function from inception to August 2023 were searched in PubMed, Web of Science, EMBASE, Scopus, Chinese National Knowledge Infrastructure (CNKI), China Biomedical Literature Database (CBM), Wanfang, VIP and Duxiu databases. Two reviewers independently screened literatures, extracted data and evaluated the quality of included studies. Meta-analysis was performed using RevMan 5.3 and Stata 17.0 software. Results A total of 34 cohorts were included. The results of meta-analysis showed that the risk of cognitive impairment in the elderly with poor oral health status was significantly higher than that in the elderly with good oral health status (RR=1.31, 95%CI 1.18-1.46, P<0.01). The results of subgroup analysis showed that there were significant differences in periodontitis disease, posterior occlusal support, dentition status, and tooth loss (P<0.05), but there was no significant difference in the oral frailty (RR=1.32, 95%CI 0.96-1.81, P=0.09). There was no significant difference in the risk of oral health status and cognitive impairment in the subgroup with a follow-up time>10 years (RR=1.01, 95%CI 0.83-1.23, P=0.90), but a significant difference was detected in the subgroup with a follow-up time ≤10 years (RR=1.48, 95%CI 1.32-1.67, P<0.001). There was no significant difference in the risk of oral health status and cognitive impairment in the moderate quality subgroup (RR=1.05, 95%CI 0.91-1.20, P=0.51), but a significant difference was detected in the high quality subgroup (RR=1.35, 95%CI 1.21-1.51, P<0.01). Conclusion Oral health status is associated with the risk of cognitive dysfunction. Table and Figures | Reference | Related Articles | Metrics | Comments（0）

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Correlation between the gene polymorphisms of interleukin and the susceptibility to pneumonoconiosis: A systematic review and meta-analysis Zheng Ling, Su Jingying, Wu Dinghui, Yao Xiangyang Clinical Focus    2023, 38 (1): 5-19.   DOI: 10.3969/j.issn.1004-583X.2023.01.001 Abstract （315）   HTML （1）    PDF（pc） （1735KB）（144）       Knowledge map    Save Objective To investigate the correlationbetween the genepolymorphisms of interleukin and the susceptibility to pneumonoconiosis. Methods Literatures reporting the correlation between the gene polymorphisms of interleukin and the susceptibility to pneumonoconiosis in the PubMed, the Cochrane Library, Embase, CNKI, Wanfang Data, Weipu Database (VIP), and Chinese Biomedical Database (CBM) and other databases, which were published from the establishment of the databases to January 8, 2022 were screened.Two researchers independently extracted data and assessed the risk of bias. Using RevMan 5.2 and Stata 14.0, allelic model, dominant model, recessive model, co-dominant models (2 models), and over-dominant model were used in the meta-analysis on the correlation between interleukin-associated gene polymorphisms and susceptibility to pneumoconiosis. Results A total of 29 eligiblestudies, involving 5 315 pneumoconiosis cases and 5 332 controls were included in the current study. There were 8 literatures reporting the IL-1β-511C/T polymorphism, and the data revealed that the recessive model (OR=1.57, 95%CI=1.06-2.33, P=0.024), and co-dominant model (TT vs CC) (OR=1.80, 95%CI=1.03-3.13, P=0.039) of the IL-1β-511C/T polymorphism were significantly correlated with the susceptibility to pneumonoconiosis. There were 6 literatures reporting the IL-1RA+2018T/C polymorphism, and the data revealed that the allele model(OR=1.65, 95%CI=1.21-2.27, P=0.002), dominant model(OR=1.65, 95%CI=1.11-2.46, P=0.013), recessive model(OR=2.14, 95%CI=1.50-3.06, P=0.000), and co-dominant model (TT vs CC) (OR=2.29, 95% CI=1.58-3.32, P=0.000) of the IL-1RA+2018T/C polymorphism were significantly correlated with the susceptibility to pneumonoconiosis. There were 4 literatures reporting the IL-1α-889C/T polymorphism, and the data revealed that the dominant model(OR=1.75, 95%CI=1.02-3.01, P=0.042), and co-dominant model (CT vs CC)(OR=1.79, 95%CI=1.21-2.636, P=0.004) of the IL-1α-889C/T polymorphism were significantly correlated with the susceptibility to pneumonoconiosis. There were 3 literatures reporting the IL-1α +4845G/T polymorphism, and the data revealed that the allele model(OR=1.59, 95%CI=1.03-2.56, P=0.038) of the IL-1α+4845G/T polymorphism was significantly correlated with the susceptibility to pneumonoconiosis. There were 4 literatures reporting the IL-6 -634C/G polymorphism, and the data revealed that the allele model(OR=0.60, 95%CI=0.47-0.75), dominant model(OR=0.47, 95% CI=0.35-0.64), co-dominant model(OR=0.63, 95%CI=0.42-0.94) (OR=0.36, 95%CI=0.24-0.54) and over-dominant model (OR=2.51, 95%CI=1.71-3.69) of the IL-6 -634C/G polymorphism were significantly correlated with the susceptibility to pneumonoconiosis. There were 2 literatures reporting the IL-8 -781C/T, IL-8-Met31Arg T/G and IL-8 -251A/T polymorphisms, and the data revealed their significant correlation with thesusceptibility to pneumonoconiosis. There was no significant correlation between IL-1β +3953C/T, IL-6 -174G/C and IL-10 -592A/C polymorphisms with the susceptibility topneumoconiosis. Conclusion IL-1RA +2018T/C and IL-6 -634 C/G polymorphisms were significantly correlated with the susceptibility to pneumoconiosis. IL-1α +4845G/T, IL-1β -511C/T and IL-1α -889C/T polymorphisms may be correlated with the susceptibility to pneumoconiosis. IL-1β +3953C/T and IL-6 -174G/C were not correlated with the susceptibility to pneumoconiosis. Our findings should be further validated in multi-center studies with a large sample size. Table and Figures | Reference | Related Articles | Metrics | Comments（0）

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Effect of semaglutide on total myocardial ischemic burden and serum inflammatory factors in patients with type 2 diabetes mellitus complicated with coronary heart disease Wang Wenqi, Zhang Tao Clinical Focus    2022, 37 (11): 996-1000.   DOI: 10.3969/j.issn.1004-583X.2022.11.006 Abstract （574）   HTML （1）    PDF（pc） （817KB）（142）       Knowledge map    Save Objective To investigate the effects of semaglutide, a once-weekly glucagon-like peptide-1 receptor agonist (GLP-1RA), on total myocardial ischemic burden and inflammatory factors in patients with type 2 diabetes mellitus (T2DM) complicated with coronary heart disease (CHD). Methods From June 2021 to June 2022, totally 96 patients with T2DM and CHD admitted to the First Affiliated Hospital of Jinzhou Medical University were retrospectively recruited. They were randomized 1∶1 to the conventional treatment group and the semaglutide treatment group. Patients in the conventional treatment group were treated with standard hypoglycemic, hypotensive, lipid-regulating, and antiplatelet medications. According to blood glucose target, insulin glargine was applied and adjusted. Semaglutide injection 1.0 mg subcutaneously, once a week, was additionally given to those in the semaglutide treatment group. The clinical manifestations, body mass index (BMI), blood pressure, fasting blood glucose (FPG), blood lipids, glycosylated hemoglobin A1c (HbA1c) and other indicators were observed in the two groups before and 3 months after treatment, and the total myocardial ischemia burden and serum inflammation indicators were detected. Results One case was lost to follow-up in both groups. At the end of the trial, clinical symptoms, FPG, blood lipid and HbA1c were significantly improved in the both groups. BMI and low-density lipoprotein cholesterol (LDL-C) in the semaglutide treatment group were significantly decreased than those in the conventional treatment group. The dosage of insulin glargine and incidence of hypoglycemia were significantly lower in the semaglutide treatment group than in the conventional treatment group. The total load of myocardial ischemia was significantly reduced in the both groups and the effect of semaglutide treatment group was better than that of the coventional treatment group. The serum levels of high sensitive C-reactive protein (hs-CRP) and interleukin-6 (IL-6) in the semaglutide treatment group were significantly decreased than those in the conventional treatment group. Conclusion Semaglutide provides clinical benefits to T2DM patients by lowering glucose, regulating lipid and reducing body weight. It delays the progression of coronary atherosclerosis in patients with T2DM and CHD, and improves myocardial ischemia and prognosis by inhibiting inflammatory response and reducing total myocardial ischemic load. Table and Figures | Reference | Related Articles | Metrics | Comments（0）

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Clinical Focus    2025, 40 (1): 90-96.   DOI: 10.3969/j.issn.1004-583X.2025.01.015 Abstract （101）   HTML （5）    PDF（pc） （1062KB）（141）       Knowledge map    Save Table and Figures | Reference | Related Articles | Metrics | Comments（0）

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Clinical Focus    2022, 37 (11): 1044-1047.   DOI: 10.3969/j.issn.1004-583X.2022.11.015 Abstract （515）   HTML （8）    PDF（pc） （796KB）（140）       Knowledge map    Save Reference | Related Articles | Metrics | Comments（0）

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Mycoplasma pneumoniae infection in Chengdu in 2021: An epidemiological study Zhang Dawei, Li Xin, Sun Guifeng Clinical Focus    2023, 38 (3): 237-240.   DOI: 10.3969/j.issn.1004-583X.2023.03.007 Abstract （394）   HTML （3）    PDF（pc） （814KB）（140）       Knowledge map    Save Objective To explore the epidemic characteristics and changing trend of mycoplasma pneumoniae (MP) infection in Chengdu in 2021, thus providing references for clinical practice.Methods A total of 10,012 patients in Chengdu, Sichuan Province with respiratory tract infection and examined with a passive agglutination assay for detecting MP antibodies (MP-Ab) in 2021 were recruited. The differences in MP infections of different age groups, male or female patients and at different seasons were observed.Results Totally 3084/10,012 (30.80%) MP-positive samples were detected. Stratified by the sex, the positive rate of MP infection in male patients was significantly lower than that of females (25.84% vs 36.12%, χ2=124.00, P<0.05). The positive rate of MP in juveniles was significantly higher than that in adults and middle-aged and elderly people (43.53% vs 33.83%, 14.03%, χ2=790.13, P<0.05). The positive rate of MP increased with aging in patients of 0-18 years. The highest and lowest positive rate of MP in minors were detected in those aged 15-17 years (61.61%) and infants younger than 1 year (4.08%), respectively. A significant difference in the positive rate of MP was detected in age groups of minors (χ2=388.27, P<0.05). Stratified by the season, the highest and lowest positive rate of MP were detected in autumn (33.67%) and summer (27.01%), respectively. No significant difference was detected in the positive rate of MP between winter and spring (χ2=1.16, P>0.05), which was significantly different between summer and autumn (χ2=28.23, P<0.05). November was the month with the highest positive rate of MP in the whole year (35.85%), and the lowest was February (21.79%). Conclusion The positive rate of MP in female is higher than that in male. Preschool children, school-age children and adolescents are susceptible populations of MP infection. In autumn and the alternating seasons of autumn and winter (i.e., September to December), MP infection is highly prevalent. MP is one of the important pathogens causing respiratory tract infection in Chengdu in 2021. Targeted prevention and control measures should be taken for susceptible populations according to the epidemiological characteristics of MP infection. Meanwhile, health education should be strengthened to prevent and control the spread of MP infection. Table and Figures | Reference | Related Articles | Metrics | Comments（0）

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Clinical Focus    2022, 37 (9): 838-841.   DOI: 10.3969/j.issn.1004-583X.2022.09.015 Abstract （374）   HTML （3）    PDF（pc） （839KB）（137）       Knowledge map    Save Reference | Related Articles | Metrics | Comments（0）

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Clinical Focus    2023, 38 (2): 175-180.   DOI: 10.3969/j.issn.1004-583X.2023.02.014 Abstract （400）   HTML （1）    PDF（pc） （1948KB）（135）       Knowledge map    Save Table and Figures | Reference | Related Articles | Metrics | Comments（0）

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Predicting the risk by FIB-4 on hepatocellular carcinoma in patients with chronic liver disease: A meta-analysis He Chao, Huang Shaobin Clinical Focus    2022, 37 (9): 779-784.   DOI: 10.3969/j.issn.1004-583X.2022.09.002 Abstract （273）   HTML （0）    PDF（pc） （1460KB）（132）       Knowledge map    Save Objective To systematically evaluate the value of fibrosis-4 (FIB-4) in predicting future hepatocellular carcinoma (HCC) in patients with chronic liver disease (CLD).Methods We searched PubMed, Web of Science, Wan-fang and CNKI databases for relevant literatures of FIB-4 predicting HCC risk in CLD patients, and selected eligible literatures according to the including and excluding criteria. Revman 5.3 software was used to perform statistical analyses.Results A total of 35 articles with 94, 569 CLD patients were included. Meta-analysis results showed that high baseline FIB-4 predicted high HCC risk in CLD patients (HR=1.57, 95%CI: 1.41-1.75, P<0.01). Post-treatment high FIB-4 (HR=2.40, 95%CI: 1.74-3.32, P<0.01) was associated with high risk of future HCC in patients with chronic hepatitis B or hepatitis C virus. Conclusion FIB-4 is useful in predicting future HCC in CLD patients. Table and Figures | Reference | Related Articles | Metrics | Comments（0）

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Clinical Focus    2023, 38 (4): 364-368.   DOI: 10.3969/j.issn.1004-583X.2023.04.014 Abstract （245）   HTML （1）    PDF（pc） （997KB）（132）       Knowledge map    Save Table and Figures | Reference | Related Articles | Metrics | Comments（0）

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Effects of common cardiovascular drugs on the risk of COVID-19 infection and poor prognosis Zhou Zihan, Cui Wei Clinical Focus    2022, 37 (10): 869-888.   DOI: 10.3969/j.issn.1004-583X.2022.10.001 Abstract （298）   HTML （1）    PDF（pc） （1215KB）（131）       Knowledge map    Save Cardiovascular disease is the most-common complication of coronavirus disease 2019 (COVID-19). During the COVID-19 pandemic, the safety and efficacy of common cardiovascular drugs such as anti-hypertensive, lipid-lowering, antiplatelet, anticoagulant, hypoglycemic and antiarrhythmic drugs have remained controversial that required improved consensuses. With the increase of global cases of COVID-19 and the occurrence of the second wave of infection, it is urgent to reveal the effects of cardiovascular disease drugs on COVID-19 patients. This study aims to summarize the relationship between common cardiovascular drugs and the risk of COVID-19 infection and poor prognosis, thus providing references for medications in COVID-19 patients with cardiovascular diseases. Table and Figures | Reference | Related Articles | Metrics | Comments（0）

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Comparative analysis on pathological results of preoperative & postoperative colorectal intraepithelial neoplasia and early colorectal cancer endoscopic therapies Shi Yujuan, Wang Jing, Xu Ping Clinical Focus    2023, 38 (1): 55-59.   DOI: 10.3969/j.issn.1004-583X.2023.01.007 Abstract （731）   HTML （0）    PDF（pc） （850KB）（130）       Knowledge map    Save Objective To provide reference for the improved pathological diagnosis of lesions of the tissues by exploring pathological differences of preoperative and postoperative endoscopic polypectomy for colorectal intraepithelial neoplasia and early colorectal cancer. Methods One hundred and twenty nine patients receiving both biopsies and surgeries based on the inclusion and exclusion criteria were selected as study samples, the specimen data and preoperative pathology biopsy data of 129 patients diagnosed with high-grade colorectal intraepithelial neoplasia or early colorectal cancer patients under endoscopic mucosal resection (EMR)/ endoscopic submucosal dissection (ESD) were retrospectively analyzed, differences in preoperative and postoperative pathological results were compared, and the risk factors associated with pathological differences in preoperative and postoperative endoscopic therapies were analyzed. Differences in the accuracy of pathological biopsies and EMR/ESD samples of patients with different parts (ascending colon, transverse colon, descending colon, sigmoid colon, rectum), lesion morphology (pedicled, sessile and lateral developmental morphology), maximum diameter of lesions, gender and age were observed. Results The diagnostic accordance rate of the postoperative pathological diagnosis of preoperative colonoscopy biopsies and endoscopic EMR/ESD therapies was 17.1% (22/129), the number of postoperative pathological ascending and descending lesions of endoscopic therapies amounted to 103 cases (79.8%) and 4 cases (3.1%), respectively, the mild-severity judgment rate of sites was 82.4%, 80.0%, 85.7%, 80.9% and 76.7%, respectively, and differences weren’t statistically significant (P>0.05). The results of single-factor Logistic regression analysis showed that the phenomenon of mild-severity judgments on preoperative biopsies was more obvious in patients with pedunculated polyps, and difference was statistically significant (P<0.05), while difference in mild-severity judgment rate for preoperative biopsies was not statistically significant for the lesion site, maximum diameter, sex, and age (P>0.05). Conclusion Both the preoperative pathological biopsy diagnosis and postoperative EMR/ESD pathological diagnosis with low compliance rate provide certain basis for selection on endoscopic follow-up and surgical treatment. Patients with pedunculated polyps are vulnerable to mild severity judgment for preoperative biopsies. Therefore, patients with pedunculated polyps are subject to intraepithelial neoplasia diagnose via biopsies, EMR/ESD surgery is supported to be selected based on the conditions in combination with narrow band imaging and magnifying endoscopy technique, and necessities for follow-up treatment and endoscopic follow-up time are supported to be determined by combining the pathological diagnosis on postoperative specimens. Table and Figures | Reference | Related Articles | Metrics | Comments（0）

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Clinical Focus    2025, 40 (1): 76-81.   DOI: 10.3969/j.issn.1004-583X.2025.01.012 Abstract （111）   HTML （3）    PDF（pc） （863KB）（130）       Knowledge map    Save Reference | Related Articles | Metrics | Comments（0）

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Risk prediction model for readmission of chronic obstructive pulmonary disease: A systematic review Zhu Jieyun, Gao Min, Huang Chunli, Pan Dongzan, Wang Qiaoyan, Lu Zhao Clinical Focus    2024, 39 (9): 773-779.   DOI: 10.3969/j.issn.1004-583X.2024.09.001 Abstract （227）   HTML （10）    PDF（pc） （597KB）（130）       Knowledge map    Save Objective To systematically evaluate the risk for readmission in patients with chronic obstructive pulmonary disease (COPD) and provide references for the construction and optimization of prediction model.Methods The literatures on the risk prediction model for COPD readmission were independently screened in China National Knowledge Infrastructure (CNKI), VIP, WanFang Data, Cochrane Library, PubMed, Embase databases from database inception to November 22, 2023 by two researchers. After extracting data, the bias risk and applicability of the models were evaluated using the PROBAST tool. Results Twelve cohort studies representing 21 models were finally included. Eleven studies reported the area under a receiver operator characteristic (ROC) curve (AUC) and one study for the C-index. The AUC ranged from 0.603 to 0.917, with AUC>0.7 for 16 models. Six studies conducted model calibration and eight studies for internal or external validation. The overall applicability of the 12 studies was good, but with a high risk of bias, mainly in the analysis domain. The included studies had significant differences in the predictive factors, with the most common predictive factors of lung function indicators, Charlson comorbidity index, times of hospitalization due to a history of acute exacerbation during the previous year, eosinophil levels, and inhaled drug therapy. Conclusion The performance of the included models varied greatly, with good applicability but high risk of bias. Due to the incomplete screening method, and there were significant differences in predictive factors of the included studies. Future prediction models should focus on lung function, Charlson comorbidity index, times of hospitalization due to a history of acute exacerbation during the previous year, eosinophil levels, and inhaled drug therapy. Table and Figures | Reference | Related Articles | Metrics | Comments（0）