Clinical Focus ›› 2026, Vol. 41 ›› Issue (4): 369-373.doi: 10.3969/j.issn.1004-583X.2026.04.013
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Received:2026-02-27
Online:2026-04-20
Published:2026-04-24
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| [1] | Chen W, Feng J, Ji P, et al. Association of hyperhomocysteinemia and chronic kidney disease in the general population: A systematic review and meta-analysis[J]. BMC Nephrol, 2023, 24(1): 247. doi:10.1186/s12882-023-03295-y. |
| [2] | Chen T, Li Y, Wang J, et al. Correlation among cystatin C, homocysteine and arteriosclerosis indexes in patients with chronic kidney disease[J]. Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2021, 46(12): 1338-1345. doi:10.11817/j.issn.1672-7347.2021.210059. |
| [3] | Azzini E, Ruggeri S, Polito A. Homocysteine: Its possible emerging role in at-risk population groups[J]. Int J Mol Sci, 2020, 21(4): 1421. doi:10.3390/ijms21041421. |
| [4] |
Wang L, Li X, Montazeri A, et al. Phenome-wide association study of genetically predicted B vitamins and homocysteine biomarkers with multiple health and disease outcomes: Analysis of the UK Biobank[J]. Am J Clin Nutr, 2023, 117(3): 564-575. doi:10.1016/j.ajcnut.2023.01.005.
pmid: 36811473 |
| [5] | Angelini A, Cappuccilli ML, Magnoni G, et al. The link between homocysteine, folic acid and vitamin B12 in chronic kidney disease[J]. G Ital Nefrol, 2021, 38(4): 2021-vol4. |
| [6] | 赵艳颖, 王素青, 王晓阳, 等. 维生素B12并烟酸缺乏症1例并文献复习[J]. 临床荟萃, 2015, 30(8):931-934. |
| [7] | 李佳宁, 刘思颖, 姜福丽, 等. 维生素B1与糖尿病微血管并发症[J]. 临床荟萃, 2012, 27(22):2013-2017. |
| [8] | Oudman E, Wijnia JW, Severs D, et al. Wernicke’s encephalopathy in acute and chronic kidney disease: A systematic review[J]. J Ren Nutr, 2024, 34(2): 105-114. doi:10.1053/j.jrn.2023.10.003. |
| [9] | Yang C, Wijerathne CUB, Tu GW, et al. Ischemia-reperfusion injury reduces kidney folate transporter expression and plasma folate levels[J]. Front Immunol, 2021, 12: 678914. doi:10.3389/fimmu.2021.678914. |
| [10] | Garibotto G, Picciotto D, Verzola D, et al. Homocysteine exchange across skeletal muscle in patients with chronic kidney disease[J]. Physiol Rep, 2023, 11(6): e15573. doi:10.14814/phy2.15573. |
| [11] | Chen W, Liang X, Liang G, et al. Hyperhomocysteinemia and its association with decreased glomerular filtration rate in patients with chronic kidney disease: A comprehensive meta-analysis[J]. PeerJ, 2025, 13: e20064. doi:10.7717/peerj.20064. |
| [12] |
Yaqub N, Zubairi AM, Kanani F, et al. An insight to hyperhomocysteinaemia in CKD patients of a tertiary care hospital, karachi[J]. J Coll Physicians Surg Pak, 2025, 35(2): 180-184. doi:10.29271/jcpsp.2025.02.180.
pmid: 39936195 |
| [13] | Xiong Y, Zhang Y, Zhang F, et al. Genetic evidence supporting the causal role of homocysteine in chronic kidney disease: A mendelian randomization study[J]. Front Nutr, 2022, 9: 843534. doi:10.3389/fnut.2022.843534. |
| [14] | Wu J, Liu D, Yang L, et al. Association between serum homocysteine levels and severity of diabetic kidney disease in 489 patients with type 2 diabetes mellitus: A single-center study[J]. Med Sci Monit, 2022, 28: e936323. |
| [15] |
Xie L, Ma S, Ding N, et al. Homocysteine induces podocyte apoptosis by regulating miR-1929-5p expression through c-Myc, DNMT1 and EZH2[J]. Mol Oncol, 2021, 15(11): 3203-3221. doi:10.1002/1878-0261.13032.
pmid: 34057794 |
| [16] | Lei Y, Liu R, Zhao Y. Serum homocysteine and left ventricular hypertrophy in adults with chronic kidney disease: A case-control study[J]. Medicine (Baltimore), 2024, 103(47): e40577. doi:10.1097/md.0000000000040577. |
| [17] | Wu HHL, McDonnell T, Chinnadurai R. Physiological associations between vitamin B deficiency and diabetic kidney disease[J]. Biomedicines, 2023, 11(4):1153. doi: 10.3390/biomedicines11041153. |
| [18] | Capelli I, Cianciolo G, Gasperoni L, et al. Folic acid and vitamin B12 administration in CKD, why not?[J]. Nutrients, 2019, 11(2): 383. doi:10.3390/nu11020383. |
| [19] | Prasad K. Atherogenic effect of homocysteine, a biomarker of inflammation and its treatment[J]. Int J Angiol, 2024, 33(4): 262-270. doi:10.1055/s-0044-1788280. |
| [20] |
Maideen NMP. Adverse effects associated with long-term use of proton pump inhibitors[J]. Chonnam Med J, 2023, 59(2): 115-127. doi:10.4068/cmj.2023.59.2.115.
pmid: 37303818 |
| [21] |
Matsumoto AK, Michelin AP, Semeão LO, et al. A randomized trial of short-term treatment with folic acid to reduce the oxidative stress of patients with chronic kidney disease[J]. Curr Drug Metab, 2021, 22(14): 1139-1150. doi:10.2174/1389200222666211210153145.
pmid: 34895119 |
| [22] | Chan CW, Lin BF. Folate deficiency enhanced inflammation and exacerbated renal fibrosis in high-fat high-fructose diet-fed mice[J]. Nutrients, 2023, 15(16):3616. doi: 10.3390/nu15163616. |
| [23] | Hasson DC, Surapaneni A, Rebholz CM, et al. Association of dietary micronutrient intake and the metabolome in children with CKD[J]. Clin J Am Soc Nephrol, 2025, 20(11): 1536-1548. doi:10.2215/CJN.0000000811. |
| [24] | Heybeli C, Kazancioglu R, Smith L, et al. Risk factors for high fall risk in elderly patients with chronic kidney disease[J]. Int Urol Nephrol, 2022, 54(2): 349-356. doi:10.1007/s11255-021-02884-w. |
| [25] |
张佳楠, 孙琳琳, 詹潇燕, 等. 血清维生素B12与老年2型糖尿病轻度认知功能障碍的关系[J]. 临床荟萃, 2024, 39(1):34-37.
doi: 10.3969/j.issn.1004-583X.2024.01.005 |
| [26] | Ledda C, Cannizzaro E, Lovreglio P, et al. Exposure to toxic heavy metals can influence homocysteine metabolism?[J]. Antioxidants (Basel), 2019, 9(1):30. doi:10.3390/antiox9010030. |
| [27] | Ashfaq F, Aljaadi AM, Salaka AS, et al. Comparison of TCN-2 (776C>G) gene polymorphism and vitamin B12 status with different body mass index among Saudi adults[J]. Life (Basel), 2023, 13(5):1185.doi:10.3390/life13051185. |
| [28] | Wang SY, Gao J, Zhao JH. Effects of high altitude on renal physiology and kidney diseases[J]. Front Physiol, 2022, 13: 969456. doi:10.3389/fphys.2022.969456. |
| [29] | Zhang L, Feng E, Baima S, et al. High altitude renal syndrome: Four elements or one source?[J]. Ren Fail, 2025, 47(1): 2482125. doi:10.1080/0886022X.2025.2482125. |
| [30] | Fitria L, Prihartono NA, Ramdhan DH, et al. Environmental and occupational risk factors associated with chronic kidney disease of unknown etiology in west javanese rice farmers, indonesia[J]. Int J Environ Res Public Health, 2020, 17(12): 4521. doi:10.3390/ijerph17124521. |
| [31] | Curran CS, Kopp JB. The complexity of nicotinamide adenine dinucleotide (NAD), hypoxic, and aryl hydrocarbon receptor cell signaling in chronic kidney disease[J]. J Transl Med, 2023, 21(1): 706. doi:10.1186/s12967-023-04584-8. |
| [32] | Juszczak AB, Kupczak M, Konecki T. Does vitamin supplementation play a role in chronic kidney disease?[J]. Nutrients, 2023, 15(13): 2847. doi:10.3390/nu15132847. |
| [33] | Galal ARM, Teama NM, Abu-Elfotuha K, et al. The potential adding therapeutic effect of pentoxifylline and/or folic acid for chronic kidney disease patients: Randomized controlled trial[J]. BMC Nephrol, 2025, 26(1): 468. doi:10.1186/s12882-025-04399-3. |
| [34] |
Sengupta P, Biswas S, Roy T. Comparative study to evaluate the effect of low-protein diet supplementation with taurine and n-acetylcysteine, n-acetylcysteine and pyridoxamine dihydrochloride in preventing the progression of chronic renal failure in patients with non-diabetic kidney disease[J]. J Assoc Physicians India, 2022, 70(5): 11-12.
pmid: 35598122 |
| [35] | Hu C, Tang T. Association between niacin intake and chronic kidney disease in male participants-a cross-sectional study from the NHANES (2005-2018)[J]. Front Nutr, 2025, 12: 1578118. doi:10.3389/fnut.2025.1578118. |
| [36] | Xiang M, Peng J, Gui Z, et al. Association of dietary niacin intake with all-cause mortality in chronic kidney disease: A retrospective cohort study of NHANES[J]. PloS One, 2025, 20(2): e0313398. doi:10.1371/journal.pone.0313398. |
| [37] | Zhou Z, Yao X. Dietary niacin intake and mortality among chronic kidney disease patients[J]. Front Nutr, 2024, 11: 1435297. doi:10.3389/fnut.2024.1435297. |
| [38] | Zhang D, Wu H, Gong S, et al. The generalized association between niacin intake and cardiovascular events in US adults living with chronic kidney disease[J]. Int J Vitam Nutr Res, 2025, 95(4): 37256. doi:10.31083/IJVNR37256. |
| [39] | Savic-Hartwig M, Kerlikowsky F, van de Flierdt E, et al. A micronutrient supplement modulates homocysteine levels regardless of vitamin B biostatus in elderly subjects[J]. Int J Vitam Nutr Res, 2024, 94(2): 120-132. doi:10.1024/0300-9831/a000777. |
| [40] | Chan CKW, Szeto CC, Lee LKC, et al. A sub-10-nm, folic acid-conjugated gold nanoparticle as self-therapeutic treatment of tubulointerstitial fibrosis[J]. Proc Natl Acad Sci U S A, 2023, 120(42): e2305662120. doi:10.1073/pnas.2305662120. |
| [41] | Yan LJ, Zhang FR, Zeng YR, et al. Serum folate and all-cause mortality is of non-linear relationship among population with chronic kidney disease: A retrospective cohort study[J]. Int J Gen Med, 2021, 14: 2695-2702. doi:10.2147/IJGM.S314904. |
| [42] |
Liu M, Ye Z, Yang S, et al. Relationship of dietary intake of food folate and synthetic folic acid intake from fortified foods with all-cause mortality in individuals with chronic kidney disease[J]. Food Funct, 2024, 15(2): 559-568. doi:10.1039/d3fo03927g.
pmid: 38164661 |
| [43] | Takahashi R, Bui TA, Elali I, et al. The association of niacin use with kidney outcomes and mortality[J]. Am J Nephrol, 2025, 56(4): 457-467. doi:10.1159/000543098. |
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