Abstract:

Objective To investigate the clinical characteristics, imaging features, pathological types, diagnosis, and diagnostic experience of diffuse pulmonary ossification (DPO). Methods A retrospective analysis was performed on one patient with DPO, and the relevant literature was reviewed. Results The patient was a middle-aged man admitted for “bilateral pulmonary nodules discovered during a routine health examination for 6 years”. He had a history of hemoptysis once and no other symptoms. During follow-up, the pulmonary nodules gradually increased in number. A diagnosis was confirmed by cryobiopsy. Because the patient had no obvious symptoms, follow-up observation was continued, and the condition remained stable. Conclusion A definite diagnosis can be established by combining the patient's medical history, imaging findings, and pathological examination. Cryobiopsy is safe, reliable, and provides adequate tissue samples, and therefore can be widely applied in the diagnosis of DPO.

Key words: diffuse pulmonary ossification, interstitial lung disease, cryobiopsy of the lung, ossification