Brain-body interaction: An integrated therapeutic framework from multi-organ axis networks to psychosomatic disorders

doi:10.3969/j.issn.1004-583X.2026.10.001

Abstract

Abstract:

Central nervous system and peripheral organs communicate through extensive bidirectional networks involving neural, endocrine, immune, and metabolic pathways, collectively referred to as the “brain-body axis”. In recent years, concepts such as the heart-brain axis, gut-brain axis, lung-brain axis, skin-brain axis, muscle-brain axis, and urogenital-brain axis have been progressively expanded, and brain-body interaction has been regarded as a core organizational mechanism underlying whole-body homeostasis and adaptive regulation. Dynamic balance of the brain-body axis sustains health; its dysregulation provides the pathophysiological basis for the coexistence of multisystem diseases and psychosomatic disorders. This article systematically summarizes the core pathways and major organ axes of brain-body interaction, elucidates the relationship between brain-body axis imbalance and psychosomatic disorders, and proposes an integrated therapeutic strategy for psychosomatic disorders. The central goal of this strategy is to restore coordinated brain-body information flow.

Key words: brain-body interaction, brain-body axis, psychosomatic diseases, multi-organ axes, integrative therapy

CLC Number:

R749.92

Wen Xiaoyu, Han Bing, Wang Yuping. Brain-body interaction: An integrated therapeutic framework from multi-organ axis networks to psychosomatic disorders[J]. Clinical Focus, 2026, 41(10): 869-873.

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URL: https://www.lchc.cn/EN/10.3969/j.issn.1004-583X.2026.10.001

https://www.lchc.cn/EN/Y2026/V41/I10/869

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