Objective  To explore the risk factors of the deep venous thrombosis(DVT). Methods  A casecontrol study was carried on DVT patients and healthy population in People's Hospital of Xinjiang Uygur Automous Region， the risk factors for the disease were explored through questionnaire and laboratory examination， synthetic analysis was made in the risk factors by logistic regression model. Results  Fruit intake(P<0.01)， pregnancy/puerperium(P<0.05)， ATⅢ(P<0.05)， protein C(P<0.05)， Hcy(P<0.05) and folic acid(P<0.05) had statistic difference between two groups. After screening the discovery with multiariable logistic regression analysis， BMI(χ2=5.59，P=0.018，OR=1.082， 95%CI=1.0141.154)， gestation(χ2=9.002， P=0.003， OR=5.038， 95%CI=1.75214.490)， plasma levels of ATⅢ(χ2=54.135，P<0.01，OR=0.937，95%CI=0.9200.953) and Hcy(χ2=20.384，P<0.001，OR=1.084，95%CI=1.0471.122) were independent risk factors for DVT. Conclusion  The plasma concentration of ATⅢ and Hcy are closely related with DVT. Fruit intake， pregnancy/puerperium and serum folate concentration are the influence factors of DVT.