Clinical Focus >

2022 , Vol. 37 >Issue 2: 128 - 132

DOI: https://doi.org/10.3969/j.issn.1004-583X.2022.02.006

Correlation between blood lipid and homocysteine and cognitive impairment in Parkinson's disease

  • Chang Guo ,
  • Huinan Shen ,
  • Yimeng Sun ,
  • Dongyu Wang
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  • 1. Gradute School of Jinzhou Medical University, Jinzhou 121000, China
    2. Northeast Yucai foreign language school, Shenyang 110000, China
    3. Department of Neurology, Central Hospital of Jinzhou, Jinzhou 121000, China

Received date: 2021-10-27

  Online published: 2022-03-04

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Abstract

Objective To investigate the correlation between the levels of blood lipid and homocysteine (Hcy) and the degree of cognitive impairment in Parkinson's disease (PD).Methods A total of 100 PD patients and 50 healthy people admitted to the Department of Neurology of Jinzhou Central Hospital during Sept 2019 - Aug 2021 were respectively registered into PD group and control group. According to the score of Montreal cognitive Assessment(MoCA), patients in PD group were divided into 38 patients with normal cognition (PD-NC), 32 patients with mild cognitive impairment (PD-MCI) and 30 patients with PD dementia (PDD). The aim was to detect levels of blood lipid and serum Hcy of all patients, explore the differences of indicators between groups, and analyze the correlation between the above indicators and the degree of cognitive impairment.Results Compared with control group, PD group had significantly higher level of Hcy (P<0.05), lower levels of total cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol(LDL-C) (P<0.05), significant differences existed in the levels of TG, LDL-C and Hcy among PD-NC subgroup, PD-MCI subgroup and PDD subgroup (P < 0.05). Logistic regression analysis showed that Hcy was an independent risk factor for PD cognitive impairment (P<0.05).Conclusion There is a certain correlation between the levels of TG, LDL-C and Hcy and the degree of cognitive impairment for PD patients.

Key words： Parkinson's disease; cognitive impairment; blood lipids; homocysteine

Cite this article

Chang Guo , Huinan Shen , Yimeng Sun , Dongyu Wang . Correlation between blood lipid and homocysteine and cognitive impairment in Parkinson's disease[J]. Clinical Focus, 2022 , 37(2) : 128 -132 . DOI: 10.3969/j.issn.1004-583X.2022.02.006

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