Association study between liver inflammation and HBeAg quantification

doi:10.3969/j.issn.1004-583X.2019.07.014

Clinical Focus

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Association study between liver inflammation and HBeAg quantification

1. Department of Laboratory, the Sixth Hospital of Shijiazhuang, Shijiazhuang 050000, China;
2a.Department of Infectious Diseases; b.Department of Laboratory, the Fifth Hospital of
Shijiazhuang, Shijiazhuang 050000, China; 3.Department of Oncology, the Affiliated Hospital of
Hebei University of Technology, Handan 056000, China

Online:2019-07-20 Published:2019-08-24
Contact: Corresponding author: Chen Xiuli, Email: 13363887189@163.com

Abstract

Abstract: Objective To discuss the correlation of chronic hepatitis B patients between liver inflammation and serum HBeAg quantification. Methods All 296 HBeAgpositive CHB patients received liver biopsy under ultrasound guidance, the scoring was based on viral hepatitis inflammatory activity standard (grade, G), and serum HBeAg quantification were quantified after serum was isolated on the same day. The three subgroups were divided according to the serum HBeAg quantification. Results Along with the progress of liver inflammation from G1 to G2, G3/G4, serum HBeAg level gradually decreased, the serum HBeAg quantification had negative correlation with liver inflammation (r=-0.513, P＜0.01). Conclusion HBeAg quantification may become a noninvasive diagnostic marker of liver inflammation degree in CHB patients.

Key words: hepatitis B, chronic, inflammation; , hepatitis e antigen, type B

Zhu Ping1, Lu Yufeng2a, Wang Li3, Wang Hong2b, Yang Li2b, . Association study between liver inflammation and HBeAg quantification[J]. Clinical Focus, doi: 10.3969/j.issn.1004-583X.2019.07.014.

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URL: http://www.lchc.cn/EN/10.3969/j.issn.1004-583X.2019.07.014

http://www.lchc.cn/EN/Y2019/V34/I7/637

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Association study between liver inflammation and HBeAg quantification

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