Abstract: Objective  To investigate the effect of lowdose etibatide combined with percutaneous coronary intervention (PCI) on blood perfusion and cardiac function in patients with acute myocardial infarction (AMI). Methods  The patients with ST segment elevation myocardial infarction (STEMI) who underwent emergency PCI  were selected.  STEMI patients who met the inclusion and exclusion criteria were randomly divided into experimental group and control group. In experimental group,  etibatide was given intravenously once (180 μg/kg) and pumped intravenously 1 μg/（kg·min）; in  control group,  neither injection nor pump was given. The observation indexes included general data,  myocardial perfusion,  cardiac function and major adverse cardiac events (MACE).Results  The rate of ST fall in experimental group was better than that in control group (P<0.05). The peak intensity (PI) in experimental group were significantly higher than that in control group,  however,  the time to peak (TP) of myocardial contrast echocardiography  was lower than that in control group (P<0.05).  LVEF in  experimental group was significantly higher than that in control group in the first month after the operation,  and BNP level in experimental group was significantly lower than that in control group in the first month (P<0.05) . Conclusion  Low dose of etibatide can improve myocardial reperfusion and cardiac function in patients with acute STEMI without increasing the incidence of MACE.

Key words: myocardial infarction, etibatide; , myocardial contrast echocardiography, cardiac function