Vitamin D deficiency and orthostatic hypotension in the elderly: A systematic review and meta-analysis

doi:10.3969/j.issn.1004-583X.2024.10.001

Abstract

Abstract:

Objective To study the relationship between vitamin D deficiency, defined as 25-hydroxyvitamin D3 (25 (OH) D3) deficiency and the risk of orthostatic hypotension (OH) in the elderly population. Methods From the establishment of the database to June 2023, a systematic literature search was conducted on Pubmed, Embase, Web of Science, Scopus, and Cochrane databases. Two researchers independently screened the included literatures, extracted data and evaluated the risk of bias of the included studies. Meta-analysis was performed using Stata software (version 17.0) and RevMan5.4 software. Results A meta-analysis was conducted using the random-effect model involving 9,155 participants from 9 cross-sectional studies. Serum 25-hydroxyvitamin D levels were measured by radioimmunoassay (RIA) and liquid chromatography mass spectrometry (LC-MS). The overall analysis results showed that vitamin D deficiency was directly correlated with OH in the elderly population. Compared with individuals with normal vitamin D levels, low serum vitamin D levels significantly increased the risk of OH in the elderly (OR=1.22, 95%CI=1.12-1.33,P<0.05). Conclusion There is a clear correlation between vitamin D deficiency and the risk of OH in the elderly.

Key words: hypotension, orthostatic, elderly, 25-hydroxyvitamin D, meta-analysis

CLC Number:

R544.2

Zhao Jiahua, Ma Qinghua, Yu Jianghua. Vitamin D deficiency and orthostatic hypotension in the elderly: A systematic review and meta-analysis[J]. Clinical Focus, 2024, 39(10): 869-876.

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URL: http://www.lchc.cn/EN/10.3969/j.issn.1004-583X.2024.10.001

http://www.lchc.cn/EN/Y2024/V39/I10/869

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References 39

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第一作者	年份	国家	样本量	性别(女) /人	25(OH)D 检测方法	中位年龄 (岁)	维生素D 缺乏组发生 OH的OR值	OR_LL	OR_UL	NOS评分
Gilani^[13]	2021	英国	3620	0(均为男性)	液相色谱-质谱法	68.6	1.31	0.96	1.78	7
Laird^[14]	2019	爱尔兰	4186	2219	液相色谱-质谱法	61.58	1.17	0.81	1.68	8
Veronese^[15]	2016	意大利	1308	781	放射免疫分析法	70	1.18	1.06	1.31	8
Veronese^[16]	2014	意大利	2640	1558	放射免疫分析法	73.8	1.08	0.77	1.51	7
Soysal^[17]	2014	土耳其	546	333	放射免疫分析法	73.4	1.47	0.931	2.322	6
McCarroll^[18]	2012	爱尔兰	76	76	放射免疫分析法	78-79	1.392	1.06	1.827	6
Duval^[19]	2016	法国	216	95	放射免疫分析法	84.9	1.644	0.533	5.072	7
Duval^[20]	2015	法国	51	25	放射免疫分析法	82	18.2	1.12	294.9	6
Annweiler^[21]	2014	法国	329	329	放射免疫分析法	83.3	1.41	0.733	2.686	7

第一作者	年份	国家	样本量	性别(女) /人	25(OH)D 检测方法	中位年龄 (岁)	维生素D 缺乏组发生 OH的OR值	OR_LL	OR_UL	NOS评分
Gilani^[13]	2021	英国	3620	0(均为男性)	液相色谱-质谱法	68.6	1.31	0.96	1.78	7
Laird^[14]	2019	爱尔兰	4186	2219	液相色谱-质谱法	61.58	1.17	0.81	1.68	8
Veronese^[15]	2016	意大利	1308	781	放射免疫分析法	70	1.18	1.06	1.31	8
Veronese^[16]	2014	意大利	2640	1558	放射免疫分析法	73.8	1.08	0.77	1.51	7
Soysal^[17]	2014	土耳其	546	333	放射免疫分析法	73.4	1.47	0.931	2.322	6
McCarroll^[18]	2012	爱尔兰	76	76	放射免疫分析法	78-79	1.392	1.06	1.827	6
Duval^[19]	2016	法国	216	95	放射免疫分析法	84.9	1.644	0.533	5.072	7
Duval^[20]	2015	法国	51	25	放射免疫分析法	82	18.2	1.12	294.9	6
Annweiler^[21]	2014	法国	329	329	放射免疫分析法	83.3	1.41	0.733	2.686	7