Correlation analysis of S-Tp and S-Te intervals with heart failure with recovered ejection fraction

doi:10.3969/j.issn.1004-583X.2025.10.003

Abstract

Abstract:

Objective To examine the correlation between the S-Tp (interval from the nadir of the S wave to the peak of the T wave) and S-Te (interval from the nadir of the S wave to the end of the T wave) on surface electrocardiography with heart failure with recovered ejection fraction (HFrecEF). Methods Consecutive patients hospitalized with heart failure at the Third People's Hospital in Liaocheng from June 2022 to June 2024 were enrolled. All patients underwent echocardiography, electrocardiography, and routine laboratory testing at baseline. The heart failure with reduced ejection fraction (HFrEF) was defined as left ventricular ejection fraction (LVEF) ≤40% at the index admission. After followup at 3 and 6 months, patients were classified at 6 months as having HFrecEF (baseline LVEF ≤40%, followup LVEF >40%, and an absolute increase ≥10%) or persistent HFrEF (all others). Betweengroup differences were assessed using independentsamples t tests. Multivariable linear regression was used to evaluate associations between S-Tp, S-Te, and heart failure-related biomarkers. Results A total of 180 patients were included; 48 (26.7%) were classified as HFrecEF and 132 (73.3%) as persistent HFrEF. Mean S-Tp and S-Te intervals were significantly shorter in HFrecEF than in persistent HFrEF (S-Tp: 0.22±0.02 ms vs 0.29±0.05 ms; S-Te: 0.31±0.05 ms vs 0.38±0.05 ms; all P<0.05). In addition, the HFrecEF group was younger and had lower rates of smoking and alcohol consumption than the HFrEF group. Serum levels of Nterminal pro-Btype natriuretic peptide (NTproBNP), low-density lipoprotein were higher than HFrecEF, cystatin C, blood urea nitrogen, and creatinine were also significantly lower in HFrecEF. In multivariable analyses, both S-Tp and S-Te were positively correlated with NTproBNP and cystatin C (all P<0.05). Conclusion S-Tp and S-Te intervals are associated with HFrecEF after treatment and may serve as independent predictors of LVEF improvement in patients initially presenting with HFrEF.

Key words: heart failure, S-Tp interval, S-Te interval, stroke volume

CLC Number:

R541.62

Liu Sanlong, Zhang Wenlong, Liu Ying, Du Guifang, Meng Zhaobin. Correlation analysis of S-Tp and S-Te intervals with heart failure with recovered ejection fraction[J]. Clinical Focus, 2025, 40(10): 893-896.

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URL: https://www.lchc.cn/EN/10.3969/j.issn.1004-583X.2025.10.003

https://www.lchc.cn/EN/Y2025/V40/I10/893

Figures/Tables 3

References 13

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项目	射血分数降低组(n=132)	射血分数改善组(n=48)	t/χ²值	P值
年龄(岁)	70.80±9.89	59.21±8.41	-7.793	0.001
男性[例(%)]	42(31.82)	18(37.50)	0.511	0.475
吸烟史[例(%)]	41(31.06)	7(14.58)	-5.278	0.022
饮酒史[例(%)]	42(31.82)	6(12.50)	-6.717	0.010
冠心病[例(%)]	82(62.12)	30(62.5)	0.002	0.963
高血压病[例(%)]	84(63.64)	28(58.33)	0.421	0.516
心房颤动[例(%)]	42(31.82)	12(36.36)	0.779	0.377
Tp-Te(ms)	0.09±0.04	0.08±0.02	-1.596	0.114
STp间期(ms)	0.29±0.05	0.22±0.02	-7.953	0.001
STe间期(ms)	0.38±0.05	0.31±0.05	-8.250	0.001
肌钙蛋白I(μg/L)	0.17±0.57	0.09±0.07	-1.596	0.114
NT-proBNP(ng/L)	6 289.92±2890.29	9 506.04±7050.38	-4.233	0.001
血红蛋白(g/L)	133.96±17.93	136.17±18.28	0.651	0.518
总胆固醇(mmol/L)	4.26±1.03	4.45±0.70	1.356	0.179
LDL(mmol/L)	2.74±0.93	3.06±0.89	2.078	0.042
总胆红素(μmol/L)	23.85±10.81	28.48±13.68	1.883	0.066
胱抑素C(mg/L)	1.05±0.64	0.78±0.61	-2.516	0.014
尿素氮(mmol/L)	8.08±4.48	5.55±3.63	-3.557	0.001
肌酐(μmol/L)	89.27±27.69	76.57±10.37	-4.463	0.001
Hcy(μmol/L)	17.21±11.71	15.10±4.65	-1.602	0.111

项目	射血分数降低组(n=132)	射血分数改善组(n=48)	t/χ²值	P值
年龄(岁)	70.80±9.89	59.21±8.41	-7.793	0.001
男性[例(%)]	42(31.82)	18(37.50)	0.511	0.475
吸烟史[例(%)]	41(31.06)	7(14.58)	-5.278	0.022
饮酒史[例(%)]	42(31.82)	6(12.50)	-6.717	0.010
冠心病[例(%)]	82(62.12)	30(62.5)	0.002	0.963
高血压病[例(%)]	84(63.64)	28(58.33)	0.421	0.516
心房颤动[例(%)]	42(31.82)	12(36.36)	0.779	0.377
Tp-Te(ms)	0.09±0.04	0.08±0.02	-1.596	0.114
STp间期(ms)	0.29±0.05	0.22±0.02	-7.953	0.001
STe间期(ms)	0.38±0.05	0.31±0.05	-8.250	0.001
肌钙蛋白I(μg/L)	0.17±0.57	0.09±0.07	-1.596	0.114
NT-proBNP(ng/L)	6 289.92±2890.29	9 506.04±7050.38	-4.233	0.001
血红蛋白(g/L)	133.96±17.93	136.17±18.28	0.651	0.518
总胆固醇(mmol/L)	4.26±1.03	4.45±0.70	1.356	0.179
LDL(mmol/L)	2.74±0.93	3.06±0.89	2.078	0.042
总胆红素(μmol/L)	23.85±10.81	28.48±13.68	1.883	0.066
胱抑素C(mg/L)	1.05±0.64	0.78±0.61	-2.516	0.014
尿素氮(mmol/L)	8.08±4.48	5.55±3.63	-3.557	0.001
肌酐(μmol/L)	89.27±27.69	76.57±10.37	-4.463	0.001
Hcy(μmol/L)	17.21±11.71	15.10±4.65	-1.602	0.111

指标	标准误	t值	P值	R值	β值	95%CI
NT-proBNP	0.000	12.961	0.001	0.696	0.000	0.000~0.000
低密度脂蛋白	0.003	-2.065	0.004	-0.114	-0.007	-0.013~0.000
胱抑素C	0.006	3.620	0.001	0.299	0.023	0.010~0.035
尿素氮	0.001	2.505	0.013	0.192	0.001	0.001~0.004
肌酐	0.000	-0.784	0.434	-0.058	0.000	0.000~0.001

指标	标准误	t值	P值	R值	β值	95%CI
NT-proBNP	0.000	12.961	0.001	0.696	0.000	0.000~0.000
低密度脂蛋白	0.003	-2.065	0.004	-0.114	-0.007	-0.013~0.000
胱抑素C	0.006	3.620	0.001	0.299	0.023	0.010~0.035
尿素氮	0.001	2.505	0.013	0.192	0.001	0.001~0.004
肌酐	0.000	-0.784	0.434	-0.058	0.000	0.000~0.001

指标	标准误	t值	P值	R值	β值	95%CI
NT-proBNP	0.000	10.952	0.001	0.615	0.000	0.000~0.000
低密度脂蛋白	0.004	1.838	0.068	0.107	0.007	0.000~0.014
胱抑素C	0.008	4.353	0.001	0.008	0.033	0.018~0.048
尿素氮	0.001	0.691	0.491	0.055	0.001	-0.001~0.003
肌酐	0.000	2.313	0.022	0.000	0.000	0.000~0.001