doi:10.3969/j.issn.1004-583X.2026.02.013

Abstract

CLC Number:

R563.8

Add to citation manager EndNote|Ris|BibTeX

URL: https://www.lchc.cn/EN/10.3969/j.issn.1004-583X.2026.02.013

https://www.lchc.cn/EN/Y2026/V41/I2/173

References 51

[1]	中国医师协会睡眠医学专业委员会,中国医师协会神经内科医师分会睡眠学组. 中国成人失眠共病阻塞性睡眠呼吸暂停诊治指南(2024年)[J]. 中华全科医师杂志, 2025, 28(11):1289-1303.
[2]	Magnusdottir S, Hill EA. Prevalence of obstructive sleep apnea (OSA) among preschool aged children in the general population: A systematic review[J]. Sleep Med Rev, 2024,73:101871. doi:10.1016/j.smrv.2023.101871.
[3]	Bosi M, De Vito A, Eckert D, et al. Qualitative phenotyping of obstructive sleep apnea and its clinical usefulness for the sleep specialist[J]. Int J Environ Res Public Health, 2020, 17(6):2058. doi:10.3390/ijerph17062058.
[4]	Iannella G, Vicini C, Colizza A, et al. Aging effect on sleepiness and apneas severity in patients with obstructive sleep apnea syndrome: A meta-analysis study[J]. Eur Arch Otorhinolaryngol, 2019, 276(12):3549-3556. doi:10.1007/s00405-019-05616-0. pmid: 31482333
[5]	Pace A, Iannella G, Rossetti V, et al. Diagnosis of obstructive sleep apnea in patients with allergic and non-allergic rhinitis[J]. Medicina (Kaunas), 2020, 56(9):454. doi:10.3390/medicina56090454.
[6]	Magliulo G, Iannella G, Ciofalo A, et al. Nasal pathologies in patients with obstructive sleep apnoea[J]. Acta Otorhinolaryngol Ital, 2019, 39(4):250-256. doi:10.14639/0392-100X-2173. pmid: 30933181
[7]	Magliulo G, De Vincentiis M, Iannella G, et al. Olfactory evaluation in obstructive sleep apnoea patients[J]. Acta Otorhinolaryngol Ital, 2018, 38(4):338-345. doi:10.14639/0392-100X-1981. pmid: 30197425
[8]	Zaffanello M, Piacentini G, Sacchetto L, et al. Sleep-disordered breathing in children with rare skeletal disorders: A survey of clinical records[J]. Med Princ Pract, 2018, 27(5):451-458. doi:10.1159/000491391. pmid: 29929197
[9]	Shen Y, Qin H, Chen J, et al. Postnatal activation of TLR4 in astrocytes promotes excitatory synaptogenesis in hippocampal neurons[J]. J Cell Biol, 2016, 215(5):719-734. doi:10.1083/jcb.201605046. pmid: 27920126
[10]	Xu J, Du W, Zhao Y, et al. Mitochondria targeting drugs for neurodegenerative diseases-Design, mechanism and application[J]. Acta Pharm SinB, 2022, 12(6):2778-2789. doi:10.1016/j.apsb.2022.03.001.
[11]	牛小莉, 徐国栋. 内质网应激与中枢神经系统退行性疾病[J]. 河北医科大学学报, 2019, 40(3): 369-372. doi: 10.3969/j.issn.10073205.2019.03.029
[12]	李晓琼, 何玲玲. 自噬与中枢神经系统退行性疾病研究进展[J]. 中风与神经疾病杂志, 2018, 35(10): 953-935.
[13]	中华医学会神经病学分会痴呆与认知障碍学组. 阿尔茨海默病源性轻度认知障碍诊疗中国专家共识[J]. 中华神经科杂志, 2022, 55(5):421-440.
[14]	Uddin MS, Kabir MT, Rahman MS, et al. Revisiting the amyloid cascade hypothesis: From anti-aβ therapeutics to auspicious new ways for Alzheimer's disease[J]. Int J Mol Sci, 2020, 21(16):5858. doi:10.3390/ijms21165858.
[15]	Johnson ECB, Bian S, Haque RU, et al. Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease[J]. Nat Med, 2023, 29(8):1979-1988. doi:10.1038/s41591-023-02476-4. pmid: 37550416
[16]	Hampel H, Hardy J, Blennow K, et al. The amyloidβ pathway in Alzheimer's disease[J]. Mol Psychiatry, 2021, 26(10): 54815503. doi:10.1038/s41380021012490.
[17]	Mayer G, Frohnhofen H, Jokisch M, et al. Associations of sleep disorders with all-cause MCI/dementia and different types of dementia-clinical evidence, potential pathomechanisms and treatment options: A narrative review[J]. Front Neurosci, 2024, 18 Front Neurosci. doi: 10.3389/fnins.2024.1372326.
[18]	Cheng JX, Ren J, Qiu J, et al. Rapid eye movement sleep and slow wave sleep rebounded and related factors during positive airway pressure therapy[J]. Sci Rep, 2021, 11(1):7599. doi: 10.1038/s41598-021-87149-3.
[19]	Owen JE, Benediktsdottir B, Cook E, et al. Alzheimer's disease neuropathology in the hippocampus and brainstem of people with obstructive sleep apnea[J]. Sleep, 2021, 44(3):zsaa195. doi: 10.1093/sleep/zsaa195.
[20]	Kazim SF, Sharma A, Saroja SR, et al. Chronic intermittent hypoxia enhances pathological tau seeding, propagation, and accumulation and exacerbates alzheimer-like memory and synaptic plasticity deficits and molecular signatures[J]. Biol Psychiatry, 2022, 91(4):346-358. doi:10.1016/j.biopsych.2021.02.973.
[21]	Shiota S, Takekawa H, Matsumoto SE, et al. Chronic intermittent hypoxia/reoxygenation facilitate amyloid-beta generation in mice[J]. J Alzheimers Dis, 2013, 37(2):325-333. doi: 10.3233/JAD-130419.
[22]	Bubu OM, Pirraglia E, Andrade AG, et al. Obstructive sleep apnea and longitudinal Alzheimer's disease biomarker changes[J]. Sleep, 2019, 42(6):zsz048. doi:10.1093/sleep/zsz048.
[23]	Sharma RA, Varga AW, Bubu OM, et al. Obstructive sleep apnea severity affects amyloid burden in cognitively normal elderly: A longitudinal study[J]. Am J Respir Crit Care Med, 2018, 197(7):933-943. doi: 10.1164/rccm.201704-0704OC.
[24]	Choe YM, Suh GH, Kim JW. Association of a history of sleep disorder with risk of mild cognitive impairment and Alzheimer's disease dementia[J]. Psychiatry Investig, 2022, 19(10):840-846. doi: 10.30773/pi.2022.0176.
[25]	Dickson DW. Neuropathology of parkinson disease[J]. parkinsonism relat disord, 2018, 46(Suppl 1):S30-S33. doi:10.1016/j.parkreldis.2017.07.033.
[26]	Liu QY, Yang M, Sheng YJ, et al. Clinical study of transcranial sonography image characteristics in patients with obstructive sleep apnea[J]. Sleep Breath, 2023, 27(4):1325-1332. doi:10.1007/s11325-022-02729-5.
[27]	Kurhaluk N, Kamiński P, Bilski R, et al. Role of antioxidants in modulating the microbiota-gut-brain axis and their impact on neurodegenerative diseases[J]. Int J Mol Sci, 2025, 26(8):3658. Published 2025 Apr 12. doi:10.3390/ijms26083658.
[28]	Bhandari UR, Danish SM, Ahmad S, et al. New opportunities for antioxidants in amelioration of neurodegenerative diseases[J]. Mech Ageing Dev, 2024,221:111961. doi:10.1016/j.mad.2024.111961.
[29]	Lord JS, Gay SM, Harper KM, et al. Early life sleep disruption potentiates lasting sex-specific changes in behavior in genetically vulnerable Shank3 heterozygous autism model mice[J]. Mol Autism, 2022, 13(1):35. doi:10.1186/s13229-022-00514-5. pmid: 36038911
[30]	Salsone M, Agosta F, Filippi M, et al. Sleep disorders and Parkinson's disease: Is there a right direction?[J]. J Neurol, 2024, 271(10):6439-6451. doi:10.1007/s00415-024-12609-5. pmid: 39133321
[31]	Yeh NC, Tien KJ, Yang CM, et al. Increased risk of parkinson's disease in patients with obstructive sleep apnea: A population-based, propensity score-matched, longitudinal follow-up study[J]. Medicine (Baltimore), 2016, 95(2):e2293. doi:10.1097/MD.0000000000002293.
[32]	Chen JC, Tsai TY, Li CY, et al. Obstructive sleep apnea and risk of Parkinson's disease: A population-based cohort study[J]. J Sleep Res, 2015, 24(4):432-437. doi:10.1111/jsr.12289.
[33]	Tarasoff-Conway JM, Carare RO, Osorio RS, et al. Clearance systems in the brain-implications for Alzheimer disease[J]. Nat Rev Neurol, 2015, 11(8):457-470. doi:10.1038/nrneurol.2015.119. pmid: 26195256
[34]	Taoka T, Naganawa S. Imaging for central nervous system (CNS) interstitial fluidopathy: Disorders with impaired interstitial fluid dynamics[J]. Jpn J Radiol, 2021, 39(1):1-14. doi:10.1007/s11604-020-01017-0.
[35]	Taoka T, Ito R, Nakamichi R, et al. Interstitial fluidopathy of the central nervous system: An umbrella term for disorders with impaired neurofluid dynamics[J]. Magn Reson Med Sci, 2024, 23(1):1-13. doi:10.2463/mrms.rev.2022-0012.
[36]	Menzies FM, Fleming A, Caricasole A, et al. Autophagy and neurodegeneration: Pathogenic mechanisms and therapeutic opportunities[J]. Neuron, 2017, 93(5):1015-1034. doi:10.1016/j.neuron.2017.01.022. pmid: 28279350
[37]	Boland B, Yu WH, Corti O, et al. Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing[J]. Nat Rev Drug Discov, 2018, 17(9):660-688. doi:10.1038/nrd.2018.109. pmid: 30116051
[38]	Szûcs A, Mutti C, Papp A, et al. REM sleep, REM parasomnias, REM sleep behaviour disorder. REM-alvás, REM-parasomniák, REM-magatartászavar[J]. Ideggyogy Sz, 2022, 75(5-06):171-182. doi:10.18071/isz.75.0171. pmid: 35819343
[39]	Sateia MJ. International classification of sleep disorders-third edition: Highlights and modifications[J]. Chest, 2014, 146(5):1387-1394. doi:10.1378/chest.14-0970I.
[40]	Si X, Guo T, Wang Z, et al. Neuroimaging evidence of glymphatic system dysfunction in possible REM sleep behavior disorder and Parkinson's disease[J]. NPJ Parkinsons Dis, 2022, 29, 8(1):54. doi: 10.1038/s41531-022-00316-9.
[41]	Högl B, Stefani A, Videnovic A. Idiopathic REM sleep behaviour disorder and neurodegeneration-an update[J]. Nat Rev Neurol, 2018, 14(1):40-55. doi:10.1038/nrneurol.2017.157.
[42]	Zhang JH, Fung SJ, Xi M, et al. Apnea produces neuronal degeneration in the pons and medulla of guinea pigs[J]. Neurobiol Dis, 2010, 40(1):251-264. doi:10.1016/j.nbd.2010.05.032.
[43]	Prineas JW, Parratt JD. Oligodendrocytes and the early multiple sclerosis lesion[J]. Ann Neurol, 2012, 72(1):18-31. doi:10.1002/ana.23634. pmid: 22829266
[44]	Aksenov DP, Rutila K, Li L, et al. Brain tissue oxygen and bold fMRI under different levels of neuronal activity[J]. Adv Exp Med Biol, 2023,1438:3-8. doi:10.1007/978-3-031-42003-0_1.
[45]	Sharma V, Verma R, Singh TG. Targeting hypoxia-related pathobiology in Alzheimer's disease: Strategies for prevention and treatment[J]. Mol Biol Rep, 2025, 52(1):416. Published 2025 Apr 23. doi:10.1007/s11033-025-10520-4. pmid: 40266407
[46]	Bhatia V, Sharma S. Role of mitochondrial dysfunction, oxidative stress and autophagy in progression of Alzheimer's disease[J]. J Neurol Sci, 2021,421:117253. doi:10.1016/j.jns.2020.117253.
[47]	Desai RA, Davies AL, Tachrount M, et al. Cause and prevention of demyelination in a model multiple sclerosis lesion[J]. Ann Neurol, 2016, 79(4):591-604. doi:10.1002/ana.24607. pmid: 26814844
[48]	Toubasi AA, Xu J, Eisma JJ, et al. Watershed regions are more susceptible to tissue microstructural injury in multiple sclerosis[J]. Brain Commun, 2024, 6(5):fcae299. doi:10.1093/braincomms/fcae299.
[49]	Ozturk B, Koundal S, Al Bizri E, et al. Continuous positive airway pressure increases CSF flow and glymphatic transport[J]. JCI Insight, 2023,8:e170270. doi: 10.1172/jci.insight.170270.
[50]	Oliver C, Li H, Biswas B, et al. A systematic review on adherence to continuous positive airway pressure (CPAP) treatment for obstructive sleep apnoea (OSA) in individuals with mild cognitive impairment and Alzheimer’s disease dementia[J]. Sleep Med Rev, 2024,73:101869. doi: 10.1016/j.smrv.2023.101869.
[51]	Lajoie AC, Gu Y, Lim A, et al. Adherence to continuous positive airway pressure for the treatment of obstructive sleep apnea in neurodegenerative diseases: A systematic review[J]. Sleep Med Rev, 2023,71:101836. doi:10.1016/j.smrv.2023.101836.

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References 51

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	Feng Yuhui, Zou Lanlan, Cui Chenhang, Huang Xianjie, Qiao Junying. Clinical value of combined serum biomarker detection for early prediction of pediatric acute respiratory distress syndrome [J]. Clinical Focus, 2025, 40(3): 237-242.
[2]	Feng Yuhui, Zou Lanlan, Li Fan, Cui Chenhang, Qiao Junying. A meta-analysis of serum von Willebrand factor expression in patients with acute lung injury/acute respiratory distress syndrome [J]. Clinical Focus, 2024, 39(10): 877-881.
[3]	Zhao Haotian, Yan Yaru, Liu Yuanlin, Long Ling, Li Li. Cardiopulmonary ultrasound-based initial diagnosis of acute respiratory distress syndrome: Literature reviews of nine cases [J]. Clinical Focus, 2024, 39(8): 741-746.
[4]	Wang Qian, Yin Wanhong, Zou Tongjuan, Tie Xin, Zhu Junchen, Chen Lyulin, Zeng Xueying. Correlation between the lung ultrasound phenotype of gravity-dependent deaeration and poor prognosis in sepsis patients requiring mechanical ventilation [J]. Clinical Focus, 2024, 39(4): 314-319.
[5]	Ma Guilan, Min Ju. Evaluation value of severity and prognosis of Lung ultrasound combined with serum NT-proBNP and sFlt-1 on acute respiratory distress syndrome in patient [J]. Clinical Focus, 2021, 36(12): 1110-1113.
[6]	Zhao Chong, Liu Zhongyang, Xu Feng, Li Huafeng. Meta-analysis of the relationship between obstructive sleep apnea hypopnea syndrome and serum lipid levels [J]. Clinical Focus, 2021, 36(3): 197-202.
[7]	Zhao Lijun;Xie Yuping;Wang Hongjing;Hui Peilin;Wei Xiaoquan;Ma Wei;Wang Jinfeng;Zhou Liya. Serum ferritin in male patients with obstructive sleep apnea-hypopnea syndrome [J]. Clinical Focus, 2015, 30(9): 1039-1.0421e+007.
[8]	. [J]. Clinical Focus, 2015, 30(6): 718-720.
[9]	GUO Chun-yan;WAND Zhong-tao;LIU Wei-ying;YU Qin. Correlation between obstructive sleep apnea-hypopnea syndrome and renal injury--a meta analysis [J]. Clinical Focus, 2014, 29(8): 841-846847.
[10]	CHANG Rong-tian;SHANG De-min;JIANG Jia-yao. Glucocorticoids in treatment of patients with acute respiratory distress syndrome in intensive care unit [J]. Clinical Focus, 2014, 29(6): 685-688.
[11]	MA Xiao-zhong. Observation of BiPAP+pressure support ventilation mode of improved sigh method in acute respiratory distress syndrome [J]. Clinical Focus, 2014, 29(5): 543-545546.
[12]	ZHANG Cheng;MA Jing;SU Li;WANG Guang-fa . Mianserin- 5-hydroxy tryptamine 1/2 receptor antagonist suppresses sleep apnea in rat [J]. CLINICAL FOCUS, 2014, 29(4): 424-427.
[13]	HU Jie-yu;QIN Hua;CHEN Zhao-yan;ZHAO Xiao-qin. Clinical analysis on 166 cases with acute respiratory distress syndrome of pulmonary origin and extra-pulmonary origin [J]. CLINICAL FOCUS, 2014, 29(3): 298-301.
[14]	LI Long;YU Qin;ZHANG Jia-bin;CHEN Ming. Role of oxidative stress and sleep structure on cognitive dysfunction in patients with obstructive sleep apnea-hypopnea syndrome [J]. CLINICAL FOCUS, 2013, 28(11): 1232-1234.
[15]	. [J]. CLINICAL FOCUS, 2013, 28(11): 1305-1308.