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miRNA	靶点	功能	参考文献
miR-200a	ZEB1/2、STAT4	低表达的miR-200a可直接上调肿瘤转录抑制因子ZEB1/2,促进EMT	杨西胜^[13],Chen等^[14]
miR-200b	ZBE1/2	起肿瘤抑制剂的作用,通过上调E-钙黏蛋白影响肿瘤细胞的迁移	Hung等^[15]
miR-200c	ZEB1/2	负调控ZEB2促进肝癌新生血管形成,加速肝癌细胞恶化	贾鹂等^[16]
miR-34a	SNAI1	减少SNAI1和波形蛋白水平并增加E-钙黏蛋白水平,达到逆转5-HT所诱导的EMT的效果	Wang等^[17]
miR-155	FN1、SNAI1、ZEB1	上调FN1、SNAI1、ZEB1和波形蛋白的表达,并下调E-钙黏蛋白的表达,进一步促进EMT	Li等^[18]
miR-21	PTEN、hSulf-1	活化AKT/ERK信号通路,促进肝癌细胞EMT	Bao等^[20]
miR-203	HOXD3、circPVT1	致癌基因circPVT1通过碱基互补配对竞争性结合miR-203,调节其表达,达到下调HOXD3的效果,最终诱导肝癌细胞增殖,促进其迁移能力	Zhu等^[25]
miR-27a-3p	Twist1	抑制肝癌细胞EMT	Zhao等^[27]
miR-29	IGF-1R、XPD	本身能够直接导致某些肿瘤的EMT;也可通过XPD-miR-29a/p53/MDM2/PDGF-B通路,抑制肝癌细胞的增殖和迁移	邬昊^[28],肖志华^[30]

miRNA	靶点	功能	参考文献
miR-200a	ZEB1/2、STAT4	低表达的miR-200a可直接上调肿瘤转录抑制因子ZEB1/2,促进EMT	杨西胜^[13],Chen等^[14]
miR-200b	ZBE1/2	起肿瘤抑制剂的作用,通过上调E-钙黏蛋白影响肿瘤细胞的迁移	Hung等^[15]
miR-200c	ZEB1/2	负调控ZEB2促进肝癌新生血管形成,加速肝癌细胞恶化	贾鹂等^[16]
miR-34a	SNAI1	减少SNAI1和波形蛋白水平并增加E-钙黏蛋白水平,达到逆转5-HT所诱导的EMT的效果	Wang等^[17]
miR-155	FN1、SNAI1、ZEB1	上调FN1、SNAI1、ZEB1和波形蛋白的表达,并下调E-钙黏蛋白的表达,进一步促进EMT	Li等^[18]
miR-21	PTEN、hSulf-1	活化AKT/ERK信号通路,促进肝癌细胞EMT	Bao等^[20]
miR-203	HOXD3、circPVT1	致癌基因circPVT1通过碱基互补配对竞争性结合miR-203,调节其表达,达到下调HOXD3的效果,最终诱导肝癌细胞增殖,促进其迁移能力	Zhu等^[25]
miR-27a-3p	Twist1	抑制肝癌细胞EMT	Zhao等^[27]
miR-29	IGF-1R、XPD	本身能够直接导致某些肿瘤的EMT;也可通过XPD-miR-29a/p53/MDM2/PDGF-B通路,抑制肝癌细胞的增殖和迁移	邬昊^[28],肖志华^[30]

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