| [1] |
Pirri C. Piezo channels in mechano-inflammation: Gatekeepers of neuroimmune crosstalk[J]. Diseases, 2025, 13(8): 263. doi: 10.3390/diseases13080263.
|
| [2] |
Xiao B. Mechanisms of mechanotransduction and physiological roles of PIEZO channels[J]. Nat Rev Mol Cell Biol, 2024, 25(11): 886-903. doi: 10.1038/s41580-024-00773-5.
|
| [3] |
Jammal Salameh L, Bitzenhofer SH, Hanganu-Opatz IL, et al. Blood pressure pulsations modulate central neuronal activity via mechanosensitive ion channels[J]. Science, 2024, 383(6682): eadk8511. doi: 10.1126/science.adk8511.
|
| [4] |
Beech DJ. PIEZO force sensing in vascular biology: An explosion of new knowledge, concepts and opportunity[J]. Advanced Science, 2025, 12(41): e11774. doi: 10.1002/advs.202511774.
|
| [5] |
Wang H, Gou Z, Chen S, et al. Piezo1 is a pathogenic gene and therapeutic target for neurological diseases[J]. Int J Neurosci, 2026, 136(2): 218-233. doi: 10.1080/00207454.2025.2496819.
|
| [6] |
Zhang Y, Liu X, Gao Y, et al. Piezo1 participates in sevoflurane-induced developmental neurotoxicity via neuroinflammation and synaptic damage in the hippocampus[J]. Int Immunopharmacol, 2025, 163: 115284. doi: 10.1016/j.intimp.2025.115284.
|
| [7] |
Yang B, Li Z, Li P, et al. Piezo1 in microglial cells:Implications for neuroinflammation and tumorigenesis[J]. Channels, 2025, 19(1): 2492161. doi: 10.1080/19336950.2025.2492161.
|
| [8] |
Habib AM, Li S, Zhang C, et al. MDFIC2 is a PIEZO channel modulator that can alleviate mechanical allodynia associated with neuropathic pain[J]. Proc Natl Acad Sci U S A, 2025, 122(45): e2512426122. doi: 10.1073/pnas.2512426122.
|
| [9] |
Wang J, Jing F, Zhao Y, et al. Piezo1: Structural pharmacology and mechanotransduction mechanisms[J]. Trends Pharmacol Sci, 2025, 36(8):752-770. doi: 10.1016/j.tips.2025.06.009.
|
| [10] |
Servin-Vences MR, Lam RM, Koolen A, et al. PIEZO2 in somatosensory neurons controls gastrointestinal transit[J]. Cell, 2023, 186(16): 3386-3399. e15. doi: 10.1016/j.cell.2023.07.00.
pmid: 37541196
|
| [11] |
Meng L, Feng J, Guo T, et al. Piezo2+ mechanosensory neurons orchestrate postnatal development through mechano-chemo-transduction of PDGFA signaling[J]. Proc Natl Acad Sci U S A, 2025, 122(28): e2504103122. doi: 10.1073/pnas.2504103122.
|
| [12] |
Chikamoto A, Meng M, Gracheva EO, et al. Velocity sensitivity of mechanotransduction in the afferent terminal underlies vibration detection in the Pacinian corpuscle[J]. Nat Commun, 2026, 17(1): 2122. doi: 10.1038/s41467-026-69251-0.
|
| [13] |
Hu J, Chen Q, Zhu H, et al. Microglial Piezo1 senses Aβ fibril stiffness to restrict Alzheimer’s disease[J]. Neuron, 2023, 111(1): 15-29. e8. doi: 10.1016/j.neuron.2022.10.021.
|
| [14] |
Li B, Zhao A, Tian T, et al. Mechanobiological insight into brain diseases based on mechanosensitive channels: Common mechanisms and clinical potential[J]. CNS Neurosci Ther, 2024, 30(6): e14809. doi: 10.1111/cns.14809.
|
| [15] |
王刚, 齐金蕾, 刘馨雅, 等. 中国阿尔茨海默病报告2024[J]. 诊断学理论与实践, 2024, 23(3):219-256. doi: 10.16150/j.1671-2870.2024.03.001.
|
| [16] |
Cavaco MA, Jang SR, Olsen C, et al. Global societal burden of alzheimer’s disease by severity:A targeted literature review[J]. Neurol Ther, 2025, 14(5): 1797-1826. doi: 10.1007/s40120-025-00815-w.
|
| [17] |
Yuan Z, Pavel MA, Hansen SB. GABA and astrocytic cholesterol determine the lipid environment of GABAAR in cultured cortical neurons[J]. Commun Biol, 2025, 8(1): 647. doi:10.1038/s42003-025-08026-7.
|
| [18] |
Chu F, Zhou X, Ma R, et al. Piezo1-targeted magnetoacoustic nanobubbles rescue alzheimer’s pathology by electromechanical neuromodulation and amyloid-β clearance[J]. ACS nano, 2025, 20(2): 1962-1982. doi: 10.1021/acsnano.5c13702.
|
| [19] |
Kornberg MD, Calabresi PA. Multiple sclerosis and other acquired demyelinating diseases of the central nervous system[J]. Cold Spring Harb Perspect Biol, 2025, 17(3): a041374. doi: 10.1101/cshperspect.a041374.
|
| [20] |
Ding YQ, Qi JG. Sensory root demyelination: Transforming touch into pain[J]. Glia, 2022, 70(3): 397-413. doi: 10.1002/glia.24097.
|
| [21] |
Zhang M, Ge Y, Wang Z, et al. Insights into the role of the mechanosensitive Piezo1 channel and signaling mechanisms in CNS functions and diseases[J]. Neurosci Biobehav Rev, 2026, 183:106562. doi: 10.1016/j.neubiorev.2026.106562.
|
| [22] |
Zhang Y, Yang X, Deng S, et al. Mechanosensitive Piezo1 channel: An emerging target in demyelination disease[J]. Front Cell Neurosci, 2025, 19: 1556892. doi: 10.3389/fncel.2025.1556892.
|
| [23] |
Qu J, Zong HF, Shan Y, et al. Piezo1 suppression reduces demyelination after intracerebral hemorrhage[J]. Neural Regen Res, 2023, 18(8): 1750-1756. doi: 10.4103/1673-5374.361531.
pmid: 36751801
|
| [24] |
Ehlers VL, Sriram A, Stuart BAR, et al. Sensory neuron PIEZO1 deletion inhibits dynamic light touch sensitivity in uninjured mice, prevents neuropathic light touch hypersensitivity, and drives compensatory changes in dorsal root ganglia[J]. Pain, 2025, 167(1):192. doi: 10.1097/j.pain.0000000000003781.
|
| [25] |
Akinci G, Ozyilmaz B, Ozturk G, et al. Genetic and clinical spectrum of PIEZO2-related disorders: Insights from a multicenter study of 26 patients[J]. Neuromuscul Disord, 2025, 53: 105423. doi: 10.1016/j.nmd.2025.105423.
|
| [26] |
邓卓越, 高宇飞. Piezo在胶质瘤中的研究进展[J]. 中国实验诊断学, 2025, 29(1):91-95. doi:10.3969/j.issn.1007-4287.2025.01.018.
|
| [27] |
Xu T, Zhang L, Lu X, et al. Piezo1 mediates ultrasound-Stimulated dopaminergic neuron potection via synaptic vesicle recycling and ferroptosis inhibition: Noninvasive ultrasound restores synaptic vesicle recycling in PD[J]. Neurosci Bull, 2025, 41(11): 1924-1938. doi: 10.1007/s12264-025-01420-5.
|
| [28] |
Liu H, Zhou L, Wang X, et al. PIEZO1 as a new target for hyperglycemic stress-induced neuropathic injury: The potential therapeutic role of bezafibrate[J]. Biomed Pharmacother, 2024, 176: 116837. doi: 10.1016/j.biopha.2024.116837.
|
| [29] |
Eom TH. Autism spectrum disorder: From screening to early diagnosis and intervention[J]. Ann Child Neurol Soc, 2025, 34(1): 41-48.8. doi: 10.26815/acn.2025.01067.
|
| [30] |
De Oliveira CA, Iorio EL, Espíndola FS. Redox system dysfunction as a key mechanism in autism spectrum disorder pathogenesis[J]. Int J Mol Sci, 2025, 26(20): 9850. doi: 10.3390/ijms26209850.
|
| [31] |
Zhai J, Hao H, Xu Z, et al. The effect of modulation Piezo2 by IGF-1 on tactile hypersensitivity in BTBR model mice[J]. Life Sci, 2025, 364: 123449.doi:10.1016/j.lfs.2025.123449.
|
| [32] |
Liu S, Liu X, Duan Y, et al. PIEZO2 is the underlying mediator for precise magnetic stimulation of PVN to improve autism-like behavior in mice[J]. J Nanobiotechnology, 2025, 23(1): 494. doi:10.1186/s12951-025-03557-x.
|
| [33] |
刘雨潇, 黄思璟, 耿珑玉, 等. PIEZO离子通道在神经系统疾病中的作用及分子机制[J]. 中国组织工程研究, 2026, 30(34):9017-9023. doi:https://doi.org/10.12307/2026.870.
|
| [34] |
Wijerathne TD, Chandrasekharan A, Bhatt A, et al. Yoda molecules agonize PIEZO2[J]. bioRxiv, 2026: 2026.05. 08.723777. doi: 10.64898/2026.05.08.723777.
|
| [35] |
Xiao B. Levering mechanically activated piezo channels for potential pharmacological intervention[J]. Annu Rev Pharmacol Toxicol, 2020, 60(1): 195-218. doi: 10.1146/annurev-pharmtox-010919-023703.
|