A meta-analysis of the relationship between H1-antihistamines and prognosis in cancer patients receiving immune checkpoint inhibitor therapy

doi:10.3969/j.issn.1004-583X.2025.08.002

Abstract

Abstract:

Objective To explore the impact of H1-antihistamines on the survival of cancer patients receiving immune checkpoint inhibitors (ICIs). Methods Articles on the efficacy of H1-antihistamines on immune checkpoint inhibitor therapy in cancer patients published before October 30, 2024 were searched in the China National Knowledge Infrastructure (CNKI), Wanfang, PubMed, Web of Science and Cochrane databases. Statistical analysis was performed using RevMan 5.4 and Stata14.0 software. Results Four studies were included in the meta-analysis. The results showed the patients treated H1-antihistamines with ICIs had significantly longer overall survival (OS) (HR=0.53, 95%CI: 0.41-0.69, P<0.00001) and progression-free survival (PFS) (HR=0.54, 95%CI: 0.44-0.65, P<0.00001) in comparison with those not receiving H1-antihistamines. Conclusion The concomitant use of H1-antihistamines is associated with improved outcomes among cancer patients treated with ICIs.

Key words: H1-antihistamines, immune checkpoint inhibitors, prognosis, meta-analysis

CLC Number:

R971.9

Ye Qian, Liu Shenxiang. A meta-analysis of the relationship between H1-antihistamines and prognosis in cancer patients receiving immune checkpoint inhibitor therapy[J]. Clinical Focus, 2025, 40(8): 684-688.

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URL: https://www.lchc.cn/EN/10.3969/j.issn.1004-583X.2025.08.002

https://www.lchc.cn/EN/Y2025/V40/I8/684

Figures/Tables 5

References 19

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第一作者	发表年份	地区	患者数量 (服用/未服用 H1抗组胺药)	肿瘤类型	H1抗组胺药类型	ICIs类型	临床结局
Chiang^[5]	2023	中国台湾	336(294/42)	肺癌	阳离子两亲性抗组胺药/非阳离子两亲性抗组胺药	PD-1/PD-L1	PFS
Mallardo^[6]	2022	苏格兰	121(71/50)	黑色素瘤	西替利嗪	PD-1	OS、PFS
EylemerMocan^[7]	2023	土耳其	133(55/78)	黑色素瘤/肾细胞癌/非小细胞肺癌/其他	扑尔敏/西替利嗪/地氯雷他定/非索非那定	PD-1/PD-L1/CTLA-4	OS、PFS
Zhang^[8]	2024	中国	211(109/102)	肺癌	苯海拉明	PD-1/PD-L1	OS、PFS

第一作者	发表年份	地区	患者数量 (服用/未服用 H1抗组胺药)	肿瘤类型	H1抗组胺药类型	ICIs类型	临床结局
Chiang^[5]	2023	中国台湾	336(294/42)	肺癌	阳离子两亲性抗组胺药/非阳离子两亲性抗组胺药	PD-1/PD-L1	PFS
Mallardo^[6]	2022	苏格兰	121(71/50)	黑色素瘤	西替利嗪	PD-1	OS、PFS
EylemerMocan^[7]	2023	土耳其	133(55/78)	黑色素瘤/肾细胞癌/非小细胞肺癌/其他	扑尔敏/西替利嗪/地氯雷他定/非索非那定	PD-1/PD-L1/CTLA-4	OS、PFS
Zhang^[8]	2024	中国	211(109/102)	肺癌	苯海拉明	PD-1/PD-L1	OS、PFS