Value of texture analysis of histograms of energy spectrum CT images in differentiating bone islands from osteoblastic bone metastases

doi:10.3969/j.issn.1004-583X.2025.08.007

Abstract

Abstract:

Objective To compare the diagnostic performance of dual-energy computed tomography (CT) images combined with histogram texture analysis in differentiating osteoblastic bone metastases (OBM) from bone islands (BI). Methods Ninety-four patients (216 lesions) undergoing spectral CT in Guangzhou Red Cross Hospital from March 21, 2023 to September 1, 2023 were enrolled. They were divided into BI group (n=81, 125 lesions) and OBM group (n=13, 91 lesions). Spectral images were reconstructed using a spectral analysis platform, generating nine monochromatic images (40-200 keV, 20 keV intervals) and conventional polychromatic images. Histogram texture parameters (entropy, mean, and maximum) were extracted from the maximal cross-sectional area of each lesion using Pyromics software. Diagnostic performance was evaluated via the receiver operating characteristic (ROC) curves, and DeLong's test compared parameter efficacy. Results At 40 keV, entropy in gray-level histogram texture analysis demonstrated a superior discrimination of OBM from BI, with an area under the curve (AUC) of 0.934(95%CI: 0.895-0.973). Entropy of conventional images by reconstructed spectral CT yielded an AUC of 0.910(95%CI: 0.872-0.949). DeLong's test confirmed significant superiority of 40 keV entropy over conventional CT (P<0.05). Conclusion Entropy of histogram texture parameters based on a 40 keV image of a plain spectral CT scan can effectively distinguish OBMs from BIs, which is higher than that of traditional images reconstructed from spectral CT.

Key words: spectral CT, osteoblastic bone metastasis, bone island

CLC Number:

R738
R730.44

Wang Bohuan, Huang Junbin, Li Zhiqiong, Xiong Yuchao, Guo Wei, Zeng Xuwen. Value of texture analysis of histograms of energy spectrum CT images in differentiating bone islands from osteoblastic bone metastases[J]. Clinical Focus, 2025, 40(8): 711-716.

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References 29

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组别	例数	病灶数	男性[例(%)]	年龄(岁)	单发[例(%)]	ROI大小(cm²)
BI组	81	125	43(53.1)	65.56±12.74	54(66.7)	18.75±13.53
OBM组	13	91	5(38.5)	67.15±6.50	3(23.1)	65.16±51.12
统计值			χ²=0.959	t=0.442	χ²=8.948	t=58.437
P值			0.381	0.660	0.003	0.001

组别	例数	病灶数	男性[例(%)]	年龄(岁)	单发[例(%)]	ROI大小(cm²)
BI组	81	125	43(53.1)	65.56±12.74	54(66.7)	18.75±13.53
OBM组	13	91	5(38.5)	67.15±6.50	3(23.1)	65.16±51.12
统计值			χ²=0.959	t=0.442	χ²=8.948	t=58.437
P值			0.381	0.660	0.003	0.001

组别	例数		传统图像		40 keV		60 keV		80 keV		100 keV
BI组	81		1 166(1 068,1 244)		2 686(2 466,2 884)		1 471(1 326,1 566)		1 027(924,1 090)		830(740,888)
OBM组	13		892(661,1 028)		2 087(1 550,2 451)		1 144(841,1 335)		804(584,943)		662(476,768)
Z值			21.663		35.466		22.971		21.065		18.917
P值			<0.001		<0.001		<0.001		<0.001		<0.001
组别		120 keV		140 keV		160 keV		180 keV		200 keV
BI组		734(655,790)		679(606,741)		648(579,709)		627(560,687)		610(548,671)
OBM组		591(422,686)		549(393,638)		524(375,609)		509(364,592)		498(356,578)
Z值		17.115		15.859		15.005		14.405		13.948
P值		<0.001		<0.001		<0.001		<0.001		<0.001

组别	例数		传统图像		40 keV		60 keV		80 keV		100 keV
BI组	81		1 166(1 068,1 244)		2 686(2 466,2 884)		1 471(1 326,1 566)		1 027(924,1 090)		830(740,888)
OBM组	13		892(661,1 028)		2 087(1 550,2 451)		1 144(841,1 335)		804(584,943)		662(476,768)
Z值			21.663		35.466		22.971		21.065		18.917
P值			<0.001		<0.001		<0.001		<0.001		<0.001
组别		120 keV		140 keV		160 keV		180 keV		200 keV
BI组		734(655,790)		679(606,741)		648(579,709)		627(560,687)		610(548,671)
OBM组		591(422,686)		549(393,638)		524(375,609)		509(364,592)		498(356,578)
Z值		17.115		15.859		15.005		14.405		13.948
P值		<0.001		<0.001		<0.001		<0.001		<0.001

组别	例数		传统图像		40 keV		60 keV		80 keV		100 keV
BI组	81		4.30(4.11,4.50)		3.94(2.92,4.36)		4.30(4.11,4.50)		4.22(4.04,4.42)		4.20(4.01,4.42)
OBM组	13		5.12(4.80,5.65)		5.49(4.99,6.05)		5.27(4.89,5.72)		5.03(4.66,5.53)		4.96(4.67,5.34)
Z值			15.009		4.467		14.252		17.437		13.065
P值			<0.001		0.036		<0.001		<0.001		<0.001
组别		120 keV		140 keV		160 keV		180 keV		200 keV
BI组		4.20(4.02,4.42)		4.17(4.01,4.36)		4.16(4.00,4.38)		4.17(3.97,4.33)		4.11(3.94,4.33)
OBM组		4.89(4.59,5.35)		4.80(4.47,5.27)		4.85(4.54,5.26)		4.77(4.48,5.27)		4.74(4.52,5.23)
Z值		15.086		16.862		14.758		17.174		17.533
P值		<0.001		<0.001		<0.001		<0.001		<0.001