Association of serum 25-hydroxyvitamin D3 with lipid profile and uric acid in middle-aged and elderly men in Chengdu

doi:10.3969/j.issn.1004-583X.2026.03.005

Abstract

Abstract:

Objective To examine the relationship between serum 25-hydroxyvitamin D₃ [25(OH)D₃] levels and lipid parameters as well as uric acid (UA) among middle-aged and elderly men in Chengdu. Methods In this cross-sectional study, 400 men (age ≥45) who visited Chengdu Second People's Hospital from January to December 2025 were enrolled. Fasting serum levels of 25(OH)D₃, triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and UA were measured. Subjects were classified by 25(OH)D₃ concentration: deficiency (<12 ng/ml), insufficiency (12-20 ng/ml), and sufficient (≥20 ng/ml). Spearman rank correlation assessed associations between 25(OH)D₃ and metabolic indicators. Binary logistic regression evaluated the association of 25(OH)D₃ with dyslipidemia and hyperuricemia. Results The combined prevalence of vitamin D insufficiency or deficiency was 34.7%. LDL-C, TC, and HDL-C differed significantly across vitamin D status groups (all P<0.05). Spearman analysis showed a positive correlation between serum 25(OH)D₃ and HDL-C (r=0.153, P<0.05), and negative correlations with LDL-C (r=-0.839) and TC(r=-0.840) (both P<0.05). No significant correlations were observed between 25(OH)D₃ and TG (P=0.059) or UA (P=0.406). In binary logistic regression, higher serum 25(OH)D₃ was associated with a lower odds of hypercholesterolemia (OR=0.975, 95%CI: 0.955-0.997, P=0.025), but showed no significant association with hyperuricemia (OR=1.017, 95%CI: 0.996-1.038, P=0.115). Conclusion A considerable portion of middle-aged and elderly men in Chengdu exhibit vitamin D insufficiency or deficiency. Serum 25(OH)D₃ is significantly associated with key lipid measures (HDL-C, LDL-C, TC), indicating a relationship between vitamin D status and lipid metabolism; however, no significant link with uric acid metabolism was detected.

Key words: calcifediol, blood lipids, uric acid

CLC Number:

R977.6

Zhang Dawei, Chen Leyi, Sun Guifeng. Association of serum 25-hydroxyvitamin D₃ with lipid profile and uric acid in middle-aged and elderly men in Chengdu[J]. Clinical Focus, 2026, 41(3): 224-227.

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URL: https://www.lchc.cn/EN/10.3969/j.issn.1004-583X.2026.03.005

https://www.lchc.cn/EN/Y2026/V41/I3/224

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References 21

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组别	例数	构成比 (%)	25(OH)D₃水平 (ng/ml)
25(OH)D₃缺乏组	24	6.0	9.18(7.81,11.01)
25(OH)D₃不足组	115	28.7	17.07(15.17,19.07)
25(OH)D₃充足组	161	65.3	29.25(23.91,36.06)
合计			23.14(17.70,33.11)

组别	例数	构成比 (%)	25(OH)D₃水平 (ng/ml)
25(OH)D₃缺乏组	24	6.0	9.18(7.81,11.01)
25(OH)D₃不足组	115	28.7	17.07(15.17,19.07)
25(OH)D₃充足组	161	65.3	29.25(23.91,36.06)
合计			23.14(17.70,33.11)

组别	例数	年龄(岁)	TG(mmol/L)	TC(mmol/L)	HDL-C(mmol/L)	LDL-C(mmol/L)	SUA(μmol/L)
25(OH)D₃缺乏组	24	68.06±15.04	1.41(1.03, 2.53)	5.32±0.53^*	1.02(0.92,1.26)^*	3.15±0.44^*	356.17±113.22
25(OH)D₃不足组	115	67.18±13.87	1.42(0.92, 2.02)	4.85±2.26^*	1.09(0.99,1.34)^*	2.88±1.82^*	388.09±97.61
25(OH)D₃充足组	161	66.34±11.59	1.30(0.86, 1.71)	3.79±0.43	1.32(1.13,1.58)	1.98±0.32	384.88±92.89
统计值		F=0.137	H=2.033	F=12.841	H=7.323	F=12.839	F=2.372
P值		0.934	0.362	<0.05	0.026	<0.05	0.305

组别	例数	年龄(岁)	TG(mmol/L)	TC(mmol/L)	HDL-C(mmol/L)	LDL-C(mmol/L)	SUA(μmol/L)
25(OH)D₃缺乏组	24	68.06±15.04	1.41(1.03, 2.53)	5.32±0.53^*	1.02(0.92,1.26)^*	3.15±0.44^*	356.17±113.22
25(OH)D₃不足组	115	67.18±13.87	1.42(0.92, 2.02)	4.85±2.26^*	1.09(0.99,1.34)^*	2.88±1.82^*	388.09±97.61
25(OH)D₃充足组	161	66.34±11.59	1.30(0.86, 1.71)	3.79±0.43	1.32(1.13,1.58)	1.98±0.32	384.88±92.89
统计值		F=0.137	H=2.033	F=12.841	H=7.323	F=12.839	F=2.372
P值		0.934	0.362	<0.05	0.026	<0.05	0.305

指标	相关系数(r)	P值
年龄	0.013	0.789
HDL-C	0.153	0.002
LDL-C	-0.839	<0.01
TG	-0.094	0.059
TC	-0.840	<0.01
UA	0.042	0.406

Association of serum 25-hydroxyvitamin D₃ with lipid profile and uric acid in middle-aged and elderly men in Chengdu

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结局变量	OR	β	标准误	Wald χ²值	P值	95%CI
结局变量	OR	β	标准误	Wald χ²值	P值	下限	上限
高胆固醇血症	0.975	-0.025	0.011	5.165	0.025	0.955	0.997
高尿酸血症	1.017	0.017	0.011	2.387	0.115	0.996	1.038

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