Observation of paliperidone palmitate injection maintenance treatment in 15 patients with schizophrenia

doi:10.3969/j.issn.1004-583X.2026.10.007

Abstract

Abstract:

Objective To observe changes in symptoms and social functioning of patients with schizophrenia during maintenance treatment with paliperidone palmitate long-acting injection. Methods Case report forms of 15 patients who were treated at Shandong Daizhuang Hospital from February 2022 to January 2026 were reviewed. Positive and Negative Syndrome Scale (PANSS), Clinical Global Impression-Severity (CGI-S), and Personal and Social Performance (PSP) scores were compared at baseline and at the last follow-up. Results The median follow-up duration was 366 days. PANSS total score decreased from 72 to 41, CGI-S decreased from 5 to 3, and PSP increased from 55 to 78 (all P<0.01). Conclusion Overall, symptom and functional scores improved in this group; however, the lack of a controlled design precludes causal inference.

Key words: schizophrenia, paliperidone palmitate, long-acting injectable, social functioning, case series

CLC Number:

R749.3

Wang Zhan, Song Haining, Gao Lingnan, Jiang Zhuo, Zhang Chenghao, Li Runze, Wang Zhonggang. Observation of paliperidone palmitate injection maintenance treatment in 15 patients with schizophrenia[J]. Clinical Focus, 2026, 41(10): 916-921.

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URL: https://www.lchc.cn/EN/10.3969/j.issn.1004-583X.2026.10.007

https://www.lchc.cn/EN/Y2026/V41/I10/916

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References 26

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指标	基线	末次随访	P值
PANSS总分	72(60,83)	41(37,46)	<0.01
阳性症状	15(11.5,19.5)	8(7,9)	<0.01
阴性症状	20(14.5,21)	12(11,14)	<0.01
一般精神病理	36(31.5,42)	20(19,21.5)	<0.01
CGI-S	5(4,5)	3(2,3)	<0.01
PSP	55(45,61.5)	78(75,80)	<0.01

指标	基线	末次随访	P值
PANSS总分	72(60,83)	41(37,46)	<0.01
阳性症状	15(11.5,19.5)	8(7,9)	<0.01
阴性症状	20(14.5,21)	12(11,14)	<0.01
一般精神病理	36(31.5,42)	20(19,21.5)	<0.01
CGI-S	5(4,5)	3(2,3)	<0.01
PSP	55(45,61.5)	78(75,80)	<0.01

编号	随访(d)	PANSS总分(分)	PSP(分)
01	307	69→37	45→75
02	738	85→48	58→75
03	308	72→37	42→75
04	368	117→62	55→76
05	307	65→55	55→60
06	367	103→37	35→78
07	392	53→40	65→85
08	308	43→44	75→74
09	368	97→38	35→80
10	187	59→43	58→80
11	367	61→41	65→80
12	368	40→33	80→90
13	362	81→51	55→78
14	366	75→41	55→82
15	188	81→34	45→80

编号	随访(d)	PANSS总分(分)	PSP(分)
01	307	69→37	45→75
02	738	85→48	58→75
03	308	72→37	42→75
04	368	117→62	55→76
05	307	65→55	55→60
06	367	103→37	35→78
07	392	53→40	65→85
08	308	43→44	75→74
09	368	97→38	35→80
10	187	59→43	58→80
11	367	61→41	65→80
12	368	40→33	80→90
13	362	81→51	55→78
14	366	75→41	55→82
15	188	81→34	45→80