Antibiotic-associated acquired factor Ⅴ inhibitor: A case report and literature review

doi:10.3969/j.issn.1004-583X.2026.01.010

Abstract

Abstract:

Objective To investigate the clinical characteristics of patients with antibiotic associated acquired factor Ⅴ inhibitor (AFⅤI). Methods We describe the clinical presentation, laboratory findings, diagnostic and therapeutic course, and outcome of a patient with antibiotic-associated AFⅤI, and we review and discuss relevant literature. Results An 84-year-old patient without a history of hereditary coagulation factor deficiency developed elevated levels of FV inhibitor after receiving antibiotics for pneumonia. Conclusion AFⅤI-related coagulopathy is a rare disorder, and exposure to antibiotics is a common precipitating factor.

Key words: blood coagulation disorders, acquired factor V inhibitors, antibiotics

CLC Number:

R554

Ren Xiyan, Ma Liyun, Ren Guanjun, Xue Qishan, Yan Chunliang, Jing Shuxian. Antibiotic-associated acquired factor Ⅴ inhibitor: A case report and literature review[J]. Clinical Focus, 2026, 41(1): 60-63.

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URL: https://www.lchc.cn/EN/10.3969/j.issn.1004-583X.2026.01.010

https://www.lchc.cn/EN/Y2026/V41/I1/60

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References 21

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项目	结果(%)
凝血因子Ⅱ	10.4 ↓
凝血因子Ⅶ	64.7
凝血因子Ⅶ	47.7 ↓
凝血因子Ⅸ	49.7 ↓
凝血因子Ⅹ	58.5
凝血因子Ⅻ	30.9 ↓
凝血因子Ⅺ	34.4 ↓
凝血因子Ⅴ	0.1 ↓ ↓

项目	结果(%)
凝血因子Ⅱ	10.4 ↓
凝血因子Ⅶ	64.7
凝血因子Ⅶ	47.7 ↓
凝血因子Ⅸ	49.7 ↓
凝血因子Ⅹ	58.5
凝血因子Ⅻ	30.9 ↓
凝血因子Ⅺ	34.4 ↓
凝血因子Ⅴ	0.1 ↓ ↓