关键词: 心力衰竭, 心室重构, 多态性, 单核苷酸, 半胱氨酸, 老年人

Abstract: ObjectiveTo investigate the distribution of MTHFR C677T genotypes on the subjects， and analyze its relationship to the ventricular remodeling in elderly patients with heart failure(HF). MethodsThe study involved 98 patients with HF as HF group， 40 health people from body check as normal control group. MTHFR C677T gene polymorphism was detected by PCRdirect sequencing method. Meanwhile， plasma total homocysteine（Hcy）  and brain natriuretic peptide(BNP) were measured. Left ventricular remodeling was evaluated by calculating the left ventricular enddiastolic diameter (LVDd)， left ventricular posterior wall thickness (LVPWT)， interventricular septal thickness (IVST) and left ventricular ejection fraction (LVEF)，left ventricular mass index(LVMI) of the subjects in two groups.ResultsCompared with those of control group， the genotype TT and allele T frequencies of C677T in MTHFR gene in HF group were significantly higher (P＜0.05). Hcy， LVMI and NTpro BNP in HF group were higher than those in control group (P＜0.05).In  HF group， LVMI was the highest， while LVEF was the lowest in TT genotype among three genotypes (P＜0.05).The frequencies of genotype TT and allele T in HF group with left ventricular hypertrophy (LVH) group were higher than those in HF without LVH group(P＜0.05).ConclusionThe MTHFR genotypes have correlation with the ventricular remodeling in elderly HF patients， and the patients with TT genotype or T allele are easier to develop into LVH.

Key words: heart failure；ventricular remodeling；polymorphism, single nucleotide, cysteine, aged