关键词: 哮喘, 支气管, 炎性体, 呼吸功能试验

Abstract: Objective  To investigate the changes of inflammatory factors in the serum of patients with acute bronchial asthma.Methods  Totally 92  patients with bronchial asthma  were divided into two groups  according to the degree of severity of acute bronchial asthma， including healthy people as the controls. Lung function and serum interleukin (IL)6， IL17， tumor necrosis factor α(TNFα) and interferon gamma (IFNγ)， transforming growth factor β2 (TGFβ2) level were detected.Results  Compared with the control group， the IL6， IL17 and   TNFα   in the asthma group were significantly increased， while IFNγ  was  significantly lower (P<0.01)， and there was no significant difference between the 3 groups of TGFβ2 (P>0.05). There were positive correlations between the severity of asthma and IL6， TNFa and IL17 (r=0.970， 0.868， 0.723，P<0.05). Severity of asthma was negatively correlated with FEV1/FVC and IFN gamma (-0.957，-0.934，P<0.05)， and not correlated with TGFB2 (r=0.321，P>0.05).Conclusion  The increase of serum inflammatory factors in patients with bronchial asthma is closely related to the incidence of asthma， and it is of certain reference value for the assessment of the severity of asthma.

Key words: asthma, bronchial；Inflammasmoes；respiratory function tests