胰高糖素样肽-1受体激动剂改善肥胖致雄性生殖功能下降的作用机制
收稿日期: 2022-05-10
网络出版日期: 2022-08-30
肥胖可以通过诱发瘦素抵抗、诱导炎症和氧化应激等多种机制影响中央和外周的下丘脑-垂体-性腺轴,导致雄性生殖功能下降,包括精子发生改变、精子数量减少、精子DNA凋亡增加、性腺功能减退、睾酮合成和分泌减少、勃起功能障碍等。近期,研究发现胰高糖素样肽-1受体激动剂通过作用于性腺轴在改善肥胖所致雄性生殖功能下降方面有着巨大的潜力,但其作用机制尚未完全阐明。本研究通过对胰高糖素样肽-1受体激动剂改善肥胖致雄性生殖功能下降的作用机制进行综述,旨在为临床诊治提供理论依据。
关键词： 肥胖症; 不育, 男(雄)性; 胰高糖素样肽-1受体激动剂
贾卓雅 , 陈晓依 , 陈树春 . 胰高糖素样肽-1受体激动剂改善肥胖致雄性生殖功能下降的作用机制[J]. 临床荟萃, 2022 , 37(7) : 658 -662 . DOI: 10.3969/j.issn.1004-583X.2022.07.015
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