收稿日期: 2023-07-05
网络出版日期: 2024-01-03
非酒精性脂肪性肝病(NAFLD)是指在没有继发于其他原因(包括过度饮酒、致脂性药物或其他肝脏疾病的原因)的情况下,肝脏脂肪积累>5%的一系列肝脏疾病,包括从单纯的脂肪变性到脂肪性肝炎,再到晚期纤维化、肝硬化,最终是肝细胞癌(HCC)的一系列变化。近期,研究发现,胰岛素样生长因子-1及其结合蛋白(IGFBP)与NAFLD的发生进展有关。IGFBP通过各种基因或细胞途径参与糖脂代谢,增强或减弱肝细胞的氧化应激、炎症、脂肪β氧化等参与NAFLD的发病过程。本文就NAFLD的流行病学、IGFBP对NAFLD发生发展的作用机制进行综述。
关键词： 非酒精性脂肪性肝病; 胰岛素样生长因子-1; 胰岛素样生长因子结合蛋白质类; 肝纤维化
熊璐 , 郭莲 . 胰岛素样生长因子-1及其结合蛋白与非酒精性脂肪性肝病发生发展的研究进展[J]. 临床荟萃, 2023 , 38(10) : 935 -939 . DOI: 10.3969/j.issn.1004-583X.2023.10.014
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