强直性脊柱炎合并急性早幼粒细胞白血病及弥散性血管内凝血1例并文献复习
Ankylosing spondylitis combined with acute promyelocytic leukaemia and disseminated intravascular coagulation: A case report and literature review
Received date: 2023-11-29
Online published: 2024-06-28
目的 探讨强直性脊柱炎(ankylosing spondylitis,AS)合并急性早幼粒细胞白血病(acute promyelocytic leukemia,APL)及弥散性血管内凝血(disseminated intravascular coagulation,DIC)的临床特点、诊断和治疗,深入了解三者之间的潜在关系和机制。方法 报告1例AS合并APL及DIC的临床特点及治疗, 结合文献进行归纳总结。结果 患者APL达到完全缓解期,继续巩固治疗。AS、APL和DIC之间的关系涉及到人白细胞抗原-B27、肿瘤坏死因子-α和白介素-23/17轴和其他免疫功能。结论 AS与APL、DIC之间的关系千丝万缕,从基因到免疫功能都存在着潜在的发病机制,其中的奥妙仍需探索。
关键词： 脊柱炎, 强直性; 白血病, 早幼粒细胞, 急性; 弥漫性血管内凝血; 人白细胞抗原-B27; 肿瘤坏死因子-α; 白介素-23/17轴
张晓阳 , 藏美荣 , 锁静 , 孟建波 , 宋晓宁 , 王金铠 . 强直性脊柱炎合并急性早幼粒细胞白血病及弥散性血管内凝血1例并文献复习[J]. 临床荟萃, 2024 , 39(4) : 342 -346 . DOI: 10.3969/j.issn.1004-583X.2024.04.008
Objective To explore the clinical characteristics, diagnosis and treatment of ankylosing spondylitis (AS) combined with acute promyelocytic leukaemia (APL) and disseminated intravascular coagulation (DIC), and to gain a deeper understanding of the potential relationship and mechanism among the three pathological conditions. Methods We reported a case of AS combined with APL and DIC. Clinical characteristics and treatment course of AS combined with APL and DIC were summarized through this case report and literature review. Results The condition of APL achieved a complete relieve, and consolidation therapy was continuously applied to this patient. The relationship among AS, APL and DIC involved human leukocyte antigen-B27, tumour necrosis factor-α and interleukin-23/17 axis and immune function. Conclusion AS is complicatedly linked with APL and DIC, with the underlying pathogenic mechanisms of gene expressions and immune function. Great efforts are needed in the future to unveil the pathogenesis of AS combined with APL and DIC.
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