脑体交互:从多器官轴网络到心身疾病的整合治疗框架

doi:10.3969/j.issn.1004-583X.2026.10.001

临床荟萃 ›› 2026, Vol. 41 ›› Issue (10): 869-873.doi: 10.3969/j.issn.1004-583X.2026.10.001

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脑体交互:从多器官轴网络到心身疾病的整合治疗框架

温晓宇¹, 韩冰¹^,², 王玉平²^,³^,⁴^,⁵()

¹ 河北医科大学第一医院神经内科, 河北石家庄 050023
² 首都医科大学宣武医院河北医院神经内科, 河北石家庄 050023
³ 河北省神经医学技术创新中心, 河北石家庄 050023
⁴ 心身医学河北省工程研究中心, 河北石家庄 050023
⁵ 首都医科大学宣武医院神经内科, 北京 100053

收稿日期:2026-10-01 出版日期:2026-10-20 发布日期:2026-10-10
通讯作者: 王玉平 E-mail:wangyuping01@sina.cn
作者简介:王玉平,男,主任医师,教授,博士生导师。首都医科大学宣武医院(国家神经疾病医学中心)神经内科首席专家、宣武医院河北医院院长。学术兼职:中华医学会心身医学分会主任委员,中华医学会神经病学分会常务委员兼睡眠障碍学组组长,中国抗癫痫协会癫痫中心规范化建设工作委员会主任委员等。主要研究方向:心身疾病、睡眠障碍、癫痫、认知障碍等脑功能性疾病的诊疗与机制研究。

Brain-body interaction: An integrated therapeutic framework from multi-organ axis networks to psychosomatic disorders

Wen Xiaoyu¹, Han Bing¹^,², Wang Yuping²^,³^,⁴^,⁵()

¹ Department of Neurology, the First Hospital of Hebei Medical University, Shijiazhuang 050023, China
² Department of Neurology, Xuanwu Hospital of Capital Medical University Hebei Hospital, Shijiazhuang 050023, China
³ Neuromedical Technology Innovation Center of Hebei Province, Shijiazhuang 050023, China
⁴ Hebei Provincial Engineering Research Center for Psychosomatic Medicine, Shijiazhuang 050023, China
⁵ Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing 100053, China

Received:2026-10-01 Online:2026-10-20 Published:2026-10-10
Contact: Wang Yuping E-mail:wangyuping01@sina.cn

摘要/Abstract

摘要：

中枢神经系统与外周器官之间通过神经、内分泌、免疫和代谢通路形成广泛的双向通信网络,即“脑-体轴”(brain-body axis)。近年来,心脑轴、肠脑轴、肺脑轴、皮肤脑轴、肌肉脑轴及泌尿生殖脑轴等概念不断丰富,脑体交互已被视为机体维持稳态与适应性调节的核心组织机制。脑-体轴的动态平衡维系着机体健康,其失衡则是导致多系统疾病与心身疾病共病的病理生理基础。本文系统总结了脑体交互的核心通路与主要器官轴,阐明脑体交互失衡与心身疾病的关系,并在此基础上提出心身疾病的整合治疗策略,其核心目标是恢复脑-体信息流的协调性。

关键词: 脑体交互, 脑-体轴, 心身疾病, 多器官轴, 整合治疗

Abstract:

Central nervous system and peripheral organs communicate through extensive bidirectional networks involving neural, endocrine, immune, and metabolic pathways, collectively referred to as the “brain-body axis”. In recent years, concepts such as the heart-brain axis, gut-brain axis, lung-brain axis, skin-brain axis, muscle-brain axis, and urogenital-brain axis have been progressively expanded, and brain-body interaction has been regarded as a core organizational mechanism underlying whole-body homeostasis and adaptive regulation. Dynamic balance of the brain-body axis sustains health; its dysregulation provides the pathophysiological basis for the coexistence of multisystem diseases and psychosomatic disorders. This article systematically summarizes the core pathways and major organ axes of brain-body interaction, elucidates the relationship between brain-body axis imbalance and psychosomatic disorders, and proposes an integrated therapeutic strategy for psychosomatic disorders. The central goal of this strategy is to restore coordinated brain-body information flow.

Key words: brain-body interaction, brain-body axis, psychosomatic diseases, multi-organ axes, integrative therapy

中图分类号:

R749.92

温晓宇, 韩冰, 王玉平. 脑体交互:从多器官轴网络到心身疾病的整合治疗框架[J]. 临床荟萃, 2026, 41(10): 869-873.

Wen Xiaoyu, Han Bing, Wang Yuping. Brain-body interaction: An integrated therapeutic framework from multi-organ axis networks to psychosomatic disorders[J]. Clinical Focus, 2026, 41(10): 869-873.

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https://www.lchc.cn/CN/Y2026/V41/I10/869

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脑体交互:从多器官轴网络到心身疾病的整合治疗框架

Brain-body interaction: An integrated therapeutic framework from multi-organ axis networks to psychosomatic disorders

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