关键词: 急性冠状动脉综合征, 抗凝药, 缺血, 出血

Abstract: Vascular endothelial damage caused by erosion or rupture of coronary atherosclerotic plaque is the pathophysiological basis of thrombosis in coronary artery lesions. The onset of acute coronary syndrome(ACS)   is often accompanied by changes in electrocardiogram,  increased markers of myocardial injury and the appearance of symptoms of angina pectoris. Antiplatelet and anticoagulant therapy is the key to the treatment of ACS. The effective use of antiplatelet and anticoagulant drugs can reduce the occurrence of ischemic events such as myocardial infarction,  thrombosis in stent and a reduction in mortality. This article reviews current  evidences for anticoagulants in ACS.

Key words: acute coronary syndrome, anticoagulants, ischemic, bleeding