关键词: 秋水仙碱, 中毒, 临床表现, 治疗与转归

Abstract: Objective  To investigate the clinical characteristics,  treatment and prognosis of colchicine poisoning,  and to raise the clinically awareness and attention of colchicine poisoning.Methods  Totally 21 literature about colchicine poisoning in recent years (20032019)were reviewed,  and 29  cases of colchicine poisoning combined with one case admitted to the hospital recently were enrolled. Results  Colchicine poisoning was found in 16 males (53.3%) and 14 females (46.7%). A total of 19 suicides (63.3%) were caused by colchicine poisoning,  and 11 patients with poisoning (36.7%) were treated with longterm medication for gout. Totally 26 patients (86.7%) showed gastrointestinal symptoms in the first stage; 21 patients (70%) showed myelosuppression and multiple organ dysfunctions in the second stage;19 patients (63.3%) got better after dangerous period.The checking results showed that the blood routine,  blood coagulation routine,  liver function and kidney function were abnormal in 26 patients (86.7%). After active symptomatic supportive treatment,  19 cases (63.3%) recovered completely and 11 cases (36.7%) died.Conclusion  If the drug dosage is not suitable,  serious poisoning reaction or even death will occur, and some people also choose oral colchicine to commit suicide.

Key words: colchicine, poisoning, clinical manifestations, treatment and outcome