冷冻肺活检确诊弥漫性肺骨化症1例

doi:10.3969/j.issn.1004-583X.2026.06.011

摘要/Abstract

摘要：

目的探讨弥漫性肺骨化症(diffuse pulmonary ossification,DPO)的临床特征、影像学表现、病理类型、诊断及经验分享。方法回顾性分析DPO 1例,并复习相关文献。结果患者中年男性,因“体检发现两肺结节6年”入院,病史中曾咯血1次,无其他症状,随诊过程中肺部结节逐渐增多。行冷冻肺活检明确诊断,因患者无明显症状,继续进行随诊观察,患者病情稳定。结论结合患者病史,影像学及病理检查可明确诊断;冷冻肺活检检查安全、可靠、取材较好,可广泛应用DPO的诊断。

关键词: 弥漫性肺骨化症, 肺疾病, 间质性, 冷冻肺活检, 骨化

Abstract:

Objective To investigate the clinical characteristics, imaging features, pathological types, diagnosis, and diagnostic experience of diffuse pulmonary ossification (DPO). Methods A retrospective analysis was performed on one patient with DPO, and the relevant literature was reviewed. Results The patient was a middle-aged man admitted for “bilateral pulmonary nodules discovered during a routine health examination for 6 years”. He had a history of hemoptysis once and no other symptoms. During follow-up, the pulmonary nodules gradually increased in number. A diagnosis was confirmed by cryobiopsy. Because the patient had no obvious symptoms, follow-up observation was continued, and the condition remained stable. Conclusion A definite diagnosis can be established by combining the patient's medical history, imaging findings, and pathological examination. Cryobiopsy is safe, reliable, and provides adequate tissue samples, and therefore can be widely applied in the diagnosis of DPO.

Key words: diffuse pulmonary ossification, interstitial lung disease, cryobiopsy of the lung, ossification

中图分类号:

R563.13

石军刚, 魏彩虹, 崔永慧, 郭丹, 李佳悦, 蔡后荣. 冷冻肺活检确诊弥漫性肺骨化症1例[J]. 临床荟萃, 2026, 41(6): 546-550.

Shi Jungang, Wei Caihong, Cui Yonghui, Guo Dan, Li Jiayue, Cai Hourong. A case of diffuse pulmonary ossification diagnosed by cryobiopsy[J]. Clinical Focus, 2026, 41(6): 546-550.

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链接本文: https://www.lchc.cn/CN/10.3969/j.issn.1004-583X.2026.06.011

https://www.lchc.cn/CN/Y2026/V41/I6/546

图/表 2

图1 2025年12月31日胸部HRCT检查像 a~c.肺窗CT:右肺中叶、两肺下叶基底段多发结节影,下肺为著, 部分融合或呈分枝状;d~f.纵膈CT:可见多发高密度钙化(箭头)

Fig.1 Chest HRCT image on December 31, 2025 a-c. Lung window CT: multiple nodular opacities are seen in the right middle lobe and the basal segments of both lower lobes, with more prominent involvement in the lower lobes; some lesions are confluent or branching in appearance; d-f. Mediastinal CT: multiple high-density calcifications are visible (arrows)

图2 右肺下叶前内基底段组织活检病理检查像(苏木精-伊红) a.肺组织内见多灶骨化生(箭头,×20);b.软骨化生、钙化(箭头,×100)

Fig.2 Pathological image of tissue biopsy from the anteromedial basal segment of the right lower lobe (hematoxylin and eosin staining) a. Multifocal osseous metaplasia is seen within the lung tissue (arrow, ×20); b. Chondroid metaplasia and calcification are present (arrow, ×100)

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