C反应蛋白-白蛋白-淋巴细胞指数对肺癌患者预后价值的系统评价与meta分析

doi:10.3969/j.issn.1004-583X.2026.06.002

摘要/Abstract

摘要：

目的系统评价C反应蛋白-白蛋白-淋巴细胞(C-reactive protein-albumin-lymphocyte, CALLY)指数与肺癌患者预后的关系。方法计算机检索PubMed、Web of Science、Cochrane Library、Embase、中国知网、维普资讯中文期刊服务平台和万方数据库,检索时限为建库至2026年4月27日。采用纽卡斯尔-渥太华量表评估文献质量,Stata 15.0软件计算合并风险比及95%置信区间,分析多因素Cox回归所报告的CALLY指数对肺癌患者总生存期与无复发生存期的预后价值。结果共纳入6篇回顾性队列研究,共2 459例肺癌患者。Meta分析结果显示,高CALLY指数与肺癌患者更优的总生存期(HR=0.59, 95%CI: 0.49~0.69, P<0.01)和无复发生存期(HR=0.64, 95%CI: 0.50~0.80, P<0.01)相关。结论治疗前CALLY指数是预测肺癌患者总生存期和无复发生存期的一个有价值的潜在生物标志物,可辅助临床预后评估。

关键词: 肺肿瘤, CALLY指数, 总生存期, 无复发生存期

Abstract:

Objective To systematically evaluate the association between the C-reactive protein-albumin-lymphocyte (CALLY) index and prognosis in patients with lung cancer. Methods A computer-based search was conducted in PubMed, Web of Science, the Cochrane Library, Embase, CNKI, VIP, and Wanfang Data, with the search period extending from database inception to April 27, 2026. Study quality was assessed using the Newcastle-Ottawa Scale. Stata 15.0 was used to calculate pooled hazard ratios and 95% confidence intervals. The prognostic value of the CALLY index for overall survival and recurrence-free survival in patients with lung cancer, as reported by multivariable Cox regression analyses, was examined. Results A total of 6 retrospective cohort studies involving 2 459 patients with lung cancer were included. The meta-analysis showed that a high CALLY index was associated with better overall survival (HR=0.59, 95%CI: 0.49-0.69, P<0.01) and recurrence-free survival (HR=0.64, 95%CI: 0.50-0.80, P<0.01) in patients with lung cancer. Conclusion The pretreatment CALLY index is a valuable potential biomarker for predicting overall survival and recurrence-free survival in patients with lung cancer and may support clinical prognostic assessment.

Key words: lung cancer, CALLY index, overall survival, recurrence-free survival

中图分类号:

R734.2

唐佳, 徐一舟, 吴娇, 张健. C反应蛋白-白蛋白-淋巴细胞指数对肺癌患者预后价值的系统评价与meta分析[J]. 临床荟萃, 2026, 41(6): 493-498.

Tang Jia, Xu Yizhou, Wu Jiao, Zhang Jian. Systematic review and meta-analysis of the prognostic value of the C-reactive protein-albumin-lymphocyte index in patients with lung cancer[J]. Clinical Focus, 2026, 41(6): 493-498.

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链接本文: https://www.lchc.cn/CN/10.3969/j.issn.1004-583X.2026.06.002

https://www.lchc.cn/CN/Y2026/V41/I6/493

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参考文献 26

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作者	发表年份	国家	研究时间 (年)	样本量	年龄 (岁)	样本获取时间	治疗	研究类型	截断值获取方法	截断值	结局指标	NOS评分 (分)
Liu等^[6]	2023	中国	2013-2018	557	61(54~67)	治疗前(首次入院后24小时内)	手术、放疗、化疗	a	最大选择秩统计量	1.32	OS	7
Mizota等^[10]	2025	日本	2013-2018	634	69(63~76)	治疗前	手术	a	受试者工作特征曲线	6.20	OS; RFS	6
Yoneyama等^[11]	2026	日本	2016-2023	329	72(67~76)	治疗前(手术前7天内)	手术	b	受试者工作特征曲线	6.53	OS; RFS	7
Kim等^[12]	2026	韩国	2011-2020	680	66(59~73)	治疗前(术前1个月内)	手术	b	最大选择秩统计量	5.14	OS; RFS	7
Akkar等^[13]	2026	土耳其	2020-2024	174	69(65~87)	治疗前(放疗前14天内)	放疗	b	受试者工作特征曲线	0.50	OS	7
Konoeda等^[14]	2026	日本	2011-2021	85	73(66~78)	治疗前(手术前1个月内)	手术	b	受试者工作特征曲线	0.97	OS; RFS	6

作者	发表年份	国家	研究时间 (年)	样本量	年龄 (岁)	样本获取时间	治疗	研究类型	截断值获取方法	截断值	结局指标	NOS评分 (分)
Liu等^[6]	2023	中国	2013-2018	557	61(54~67)	治疗前(首次入院后24小时内)	手术、放疗、化疗	a	最大选择秩统计量	1.32	OS	7
Mizota等^[10]	2025	日本	2013-2018	634	69(63~76)	治疗前	手术	a	受试者工作特征曲线	6.20	OS; RFS	6
Yoneyama等^[11]	2026	日本	2016-2023	329	72(67~76)	治疗前(手术前7天内)	手术	b	受试者工作特征曲线	6.53	OS; RFS	7
Kim等^[12]	2026	韩国	2011-2020	680	66(59~73)	治疗前(术前1个月内)	手术	b	最大选择秩统计量	5.14	OS; RFS	7
Akkar等^[13]	2026	土耳其	2020-2024	174	69(65~87)	治疗前(放疗前14天内)	放疗	b	受试者工作特征曲线	0.50	OS	7
Konoeda等^[14]	2026	日本	2011-2021	85	73(66~78)	治疗前(手术前1个月内)	手术	b	受试者工作特征曲线	0.97	OS; RFS	6

亚组	研究数量	样本量	HR	95%CI	I²(%)
国家
中国	1	557	0.71	0.55~0.91	-
韩国	1	680	0.40	0.26~0.64	-
日本	3	1048	0.54	0.40~0.71	10.1
研究类型
多中心	2	1191	0.68	0.56~0.84	0
单中心	3	1094	0.43	0.32~0.57	0
截断值获取方法
最大选择秩统计量	2	1237	0.62	0.50~0.77	78.9
受试者工作特征曲线	3	1048	0.54	0.41~0.71	10.1

亚组	研究数量	样本量	HR	95%CI	I²(%)
国家
中国	1	557	0.71	0.55~0.91	-
韩国	1	680	0.40	0.26~0.64	-
日本	3	1048	0.54	0.40~0.71	10.1
研究类型
多中心	2	1191	0.68	0.56~0.84	0
单中心	3	1094	0.43	0.32~0.57	0
截断值获取方法
最大选择秩统计量	2	1237	0.62	0.50~0.77	78.9
受试者工作特征曲线	3	1048	0.54	0.41~0.71	10.1