Ezrin蛋白在细胞功能及疾病中的多重作用及临床转化潜力研究进展

doi:10.3969/j.issn.1004-583X.2026.08.016

摘要/Abstract

摘要：

埃兹蛋白(Ezrin)作为ERM(Ezrin-Radixin-Moesin)家族核心骨架连接蛋白,是维系细胞膜-细胞骨架结构完整性、介导多通路信号级联传导的关键调控分子,通过构象动态转换参与细胞稳态维持、迁移侵袭、凋亡调控等多种核心病理生理过程。近年来大量基础与临床研究证实,Ezrin蛋白异常表达与活化状态失衡,是恶性肿瘤、妇科良性病变、呼吸系统疾病、糖代谢疾病等多种疾病发生、进展及预后转归过程中的重要调控因素之一,具备理想的疾病诊断标志物与靶向治疗靶点潜力。本文系统综述Ezrin蛋白的分子结构、活化调控机制及核心生物学功能,重点剖析其在不同疾病中的特异性作用机制、表达特征及临床意义,归纳其在生理稳态与病理损伤中的调控共性与差异化特征,阐释其双向调控细胞凋亡等关键生物学现象的分子决定因素,结合现有研究短板与临床转化瓶颈,展望Ezrin蛋白在疾病精准诊断、预后评估及靶向干预中的应用前景,旨在为相关疾病的机制研究与新型治疗策略开发提供理论参考。

关键词: Ezrin蛋白, ERM蛋白家族, 细胞骨架重塑, 信号通路调控, 疾病发生发展, 靶向治疗

中图分类号:

R730.2

周闻. Ezrin蛋白在细胞功能及疾病中的多重作用及临床转化潜力研究进展[J]. 临床荟萃, 2026, 41(8): 763-768.

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https://www.lchc.cn/CN/Y2026/V41/I8/763

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