左氧氟沙星与米诺环素治疗大环内酯类耐药肺炎支原体肺炎患儿的临床疗效对比

doi:10.3969/j.issn.1004-583X.2025.09.008

摘要/Abstract

摘要：

目的对比左氧氟沙星与米诺环素治疗大环内酯类耐药肺炎支原体肺炎(macrolide-resistant $M y c o p l a s m a p n e u m o n i a e$ pneumonia,MRMP)患儿的临床疗效及安全性,分析两种药物在轻症、中症及重症亚组中的治疗差异,为MRMP的用药提供依据。方法纳入2023年5月至2024年10月解放军总医院第八医学中心及新乡医学院第一附属医院收治的MRMP患儿204例,按治疗药物分为左氧氟沙星组( $n$ =65)和米诺环素组( $n$ =139)。主要观察指标包括:①康复指标(体温恢复、咳嗽缓解、水泡音消失等);②炎症指标;③总有效率;④短期及远期不良反应。结果左氧氟沙星组与米诺环素组总有效率差异无统计学意义( $P$ >0.05)。两组体温恢复时间、咳嗽缓解时间、喘息缓解时间、水泡音消失时间及影像学改善时间差异均无统计学意义( $P$ >0.05)。两组治疗前后白细胞计数、C-反应蛋白、降钙素原、红细胞沉降率、白介素-6、乳酸脱氢酶等炎症指标水平差异均无统计学意义( $P$ >0.05)。然而,重症亚组中,米诺环素组水泡音消失时间短于左氧氟沙星组,差异有统计学意义( $P$ <0.05)。安全性方面,短期不良反应以轻度胃肠反应为主,未发现肝肾功能异常或远期不良反应。结论左氧氟沙星与米诺环素治疗MRMP患儿的总体疗效与安全性相当,但米诺环素因高脂溶性和强肺组织渗透性,在重症患儿中可更快缓解肺部体征。临床应根据患儿年龄及病情严重程度制定个体化治疗方案。

关键词: 儿童, 大环内酯类耐药肺炎支原体肺炎, 左氧氟沙星, 米诺环素

Abstract:

Objective To compare the clinical efficacy and safety of levofloxacin versus minocycline in treating children with macrolide-resistant $M y c o p l a s m a p n e u m o n i a e$ pneumonia (MRMP), and to analyze the therapeutic differences between the two drugs in mild, moderate, and critical subgroups, thus providing a basis for the drug use in MRMP. Methods A total of 204 children with MRMP admitted to the Eighth Medical Center of the PLA General Hospital and the First Affiliated Hospital of Xinxiang Medical University from May 2023 to October 2024 were included. They were divided into the levofloxacin group ( $n$ =65) and the minocycline group ( $n$ =139) based on the treatment drug. Outcomes included rehabilitation indicators (e.g., temperature recovery, cough relief, disappearance of rales), inflammatory indicators, overall effectiveness, and short-term and long-term adverse reactions. Results There was no significant difference in the overall effectiveness rate between the levofloxacin group and the minocycline group ( $P$ >0.05). Body temperature recovery time, cough relief time, wheezing relief time, blister sound disappearance time and imaging improvement time were comparable between the two groups ( $P$ >0.05). Differences in the white blood cell count, C-reactive protein, procalcitonin, erythrocyte sedimentation rate, interleukin-6, lactate dehydrogenase and other inflammatory indicators before and after treatment were comparable between the two groups ( $P$ >0.05). However, in the critical subgroup, the time for rales to disappear in the minocycline group was significantly shorter than that in the levofloxacin group ( $P$ <0.05). In terms of safety, short-term adverse reactions were mainly mild gastrointestinal reactions, without abnormalities in liver and kidney functions and long-term adverse reactions. Conclusion The overall efficacy and safety of levofloxacin and minocycline in treating children with MRMP are comparable. Minocycline, due to its high lipid solubility and strong lung tissue penetration, can relieve pulmonary signs faster in critically ill children. Clinicians should develop individualized treatment plans based on the age of children and the severity of the disease.

Key words: children, macrolide-resistant $Mycoplasma\mathrm{ }pneumoniae$ $M y c o p l a s m a p n e u m o n i a e$ pneumonia, levofloxacin, minocycline

中图分类号:

R725.6

刘娇, 尚云, 崔清洋, 张贺, 邱萌. 左氧氟沙星与米诺环素治疗大环内酯类耐药肺炎支原体肺炎患儿的临床疗效对比[J]. 临床荟萃, 2025, 40(9): 821-827.

Liu Jiao, Shang Yun, Cui Qingyang, Zhang He, Qiu Meng. Clinical efficacy of levofloxacin versus minocycline in the treatment of children with macrolide-resistant Mycoplasma pneumoniae pneumonia[J]. Clinical Focus, 2025, 40(9): 821-827.

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链接本文: https://www.lchc.cn/CN/10.3969/j.issn.1004-583X.2025.09.008

https://www.lchc.cn/CN/Y2025/V40/I9/821

图/表 12

表1 两组一般资料比较

Tab.1 Comparison of general data between the two groups

组别	例数	性别[例(%)]		年龄 (岁)	病情严重程度[例(%)]			住院时间 (d)	支原体耐药阳性[例(%)]
组别	例数	男	女	年龄 (岁)	轻症	中症	重症	住院时间 (d)	支原体耐药阳性[例(%)]
左氧氟沙星组	65	36(55.4)	29(44.6)	7.28±3.17	5(7.7)	52(80.0)	8(12.3)	9.05±2.77	57(87.7)
米诺环素组	139	74(53.2)	65(46.8)	8.76±2.64	15(10.8)	108(77.7)	16(11.5)	7.56±2.14	117(84.2)
统计值		χ²=0.642		$t$ =0.613	χ²=2.781			$t$ =1.204	χ²=0.593
$P$ 值		0.422		0.541	0.257			0.229	0.443

表1 两组一般资料比较

Tab.1 Comparison of general data between the two groups

组别	例数	性别[例(%)]		年龄 (岁)	病情严重程度[例(%)]			住院时间 (d)	支原体耐药阳性[例(%)]
组别	例数	男	女	年龄 (岁)	轻症	中症	重症	住院时间 (d)	支原体耐药阳性[例(%)]
左氧氟沙星组	65	36(55.4)	29(44.6)	7.28±3.17	5(7.7)	52(80.0)	8(12.3)	9.05±2.77	57(87.7)
米诺环素组	139	74(53.2)	65(46.8)	8.76±2.64	15(10.8)	108(77.7)	16(11.5)	7.56±2.14	117(84.2)
统计值		χ²=0.642		$t$ =0.613	χ²=2.781			$t$ =1.204	χ²=0.593
$P$ 值		0.422		0.541	0.257			0.229	0.443

表2 两组临床疗效比较[例(%)]

Tab.2 Comparison of clinical efficacy between the two groups (n, %)

组别	例数	显效	有效	无效	总有效
左氧氟沙星组	65	20(30.8)	25(38.4)	20(30.8)	45(69.2)
米诺环素组	139	40(28.8)	58(41.7)	41(29.5)	98(70.5)
χ²值					1.740
$P$ 值					0.418

表2 两组临床疗效比较[例(%)]

Tab.2 Comparison of clinical efficacy between the two groups (n, %)

组别	例数	显效	有效	无效	总有效
左氧氟沙星组	65	20(30.8)	25(38.4)	20(30.8)	45(69.2)
米诺环素组	139	40(28.8)	58(41.7)	41(29.5)	98(70.5)
χ²值					1.740
$P$ 值					0.418

表3 两组康复指标比较

Tab.3 Comparison of rehabilitation indicators between the two groups

指标	例数	体温恢复(d)	咳嗽缓解(d)	喘息缓解(d)	水泡音消失(d)	影像学改善(d)
左氧氟沙星组	65	1.46±0.76	2.22±1.05	3.00±1.12	4.43±2.04	9.27±2.76
米诺环素组	139	1.32±0.71	2.04±0.87	2.81±1.08	4.10±2.03	8.89±2.58
$t$ 值		1.122	1.117	0.994	0.962	1.007
$P$ 值		0.263	0.265	0.322	0.337	0.315

表3 两组康复指标比较

Tab.3 Comparison of rehabilitation indicators between the two groups

指标	例数	体温恢复(d)	咳嗽缓解(d)	喘息缓解(d)	水泡音消失(d)	影像学改善(d)
左氧氟沙星组	65	1.46±0.76	2.22±1.05	3.00±1.12	4.43±2.04	9.27±2.76
米诺环素组	139	1.32±0.71	2.04±0.87	2.81±1.08	4.10±2.03	8.89±2.58
$t$ 值		1.122	1.117	0.994	0.962	1.007
$P$ 值		0.263	0.265	0.322	0.337	0.315

表4 两组炎症指标比较

Tab.4 Comparison of inflammatory indicators between the two groups

组别	例数		WBC计数(×10⁹/L)				CRP(mg/L)				PCT(μg/L)
组别	例数		治疗前		治疗后		治疗前		治疗后		治疗前		治疗后
左氧氟沙星组	65		7.68±2.87		6.12±2.35		13.52±10.84		1.28±0.96		0.25±0.18		0.10±0.06
米诺环素组	139		7.24±2.76		5.98±2.28		14.77±12.36		1.45±1.12		0.23±0.16		0.09±0.05
$t$ 值			1.014		0.373		-0.624		-0.918		0.684		1.017
$P$ 值			0.312		0.710		0.533		0.360		0.495		0.310
组别		ESR(mm/h)				IL-6(ng/L)				LDH(U/L)
组别		治疗前		治疗后		治疗前		治疗后		治疗前		治疗后
左氧氟沙星组		14.67±9.25		12.56±7.43		10.54±8.62		2.15±1.43		247.54±68.73		206.38±54.62
米诺环素组		13.88±8.76		11.94±7.02		11.23±9.15		2.08±1.36		238.67±63.45		201.47±51.34
$t$ 值		0.518		0.517		-0.449		0.292		0.829		0.543
$P$ 值		0.605		0.606		0.654		0.771		0.408		0.588

表4 两组炎症指标比较

Tab.4 Comparison of inflammatory indicators between the two groups

组别	例数		WBC计数(×10⁹/L)				CRP(mg/L)				PCT(μg/L)
组别	例数		治疗前		治疗后		治疗前		治疗后		治疗前		治疗后
左氧氟沙星组	65		7.68±2.87		6.12±2.35		13.52±10.84		1.28±0.96		0.25±0.18		0.10±0.06
米诺环素组	139		7.24±2.76		5.98±2.28		14.77±12.36		1.45±1.12		0.23±0.16		0.09±0.05
$t$ 值			1.014		0.373		-0.624		-0.918		0.684		1.017
$P$ 值			0.312		0.710		0.533		0.360		0.495		0.310
组别		ESR(mm/h)				IL-6(ng/L)				LDH(U/L)
组别		治疗前		治疗后		治疗前		治疗后		治疗前		治疗后
左氧氟沙星组		14.67±9.25		12.56±7.43		10.54±8.62		2.15±1.43		247.54±68.73		206.38±54.62
米诺环素组		13.88±8.76		11.94±7.02		11.23±9.15		2.08±1.36		238.67±63.45		201.47±51.34
$t$ 值		0.518		0.517		-0.449		0.292		0.829		0.543
$P$ 值		0.605		0.606		0.654		0.771		0.408		0.588

表5 两组短期不良反应比较[例(%)]

Tab.5 Comparison of short-term adverse reactions between the two groups (n, %)

组别	例数	胃肠反应	肝功能异常	肾功能异常	皮疹	心脏副作用
左氧氟沙星组	65	7(10.8)	0	0	3(4.6)	0
米诺环素组	139	12(8.6)	0	0	6(4.3)	0
χ²值		0.334	-	-	0.015	-
$P$ 值		0.563	-	-	0.903	-

表5 两组短期不良反应比较[例(%)]

Tab.5 Comparison of short-term adverse reactions between the two groups (n, %)

组别	例数	胃肠反应	肝功能异常	肾功能异常	皮疹	心脏副作用
左氧氟沙星组	65	7(10.8)	0	0	3(4.6)	0
米诺环素组	139	12(8.6)	0	0	6(4.3)	0
χ²值		0.334	-	-	0.015	-
$P$ 值		0.563	-	-	0.903	-

表6 两组远期不良反应比较[例(%)]

Tab.6 Comparison of long-term adverse reactions between the two groups (n, %)

组别	例数	肌腱炎、跟腱断裂	关节痛	软骨发育不良	四环素牙
左氧氟沙星组	65	0	0	0	0
米诺环素组	139	0	0	0	0
χ²值		-	-	-	-
$P$ 值		-	-	-	-

表6 两组远期不良反应比较[例(%)]

Tab.6 Comparison of long-term adverse reactions between the two groups (n, %)

组别	例数	肌腱炎、跟腱断裂	关节痛	软骨发育不良	四环素牙
左氧氟沙星组	65	0	0	0	0
米诺环素组	139	0	0	0	0
χ²值		-	-	-	-
$P$ 值		-	-	-	-

表7 轻症亚组炎症指标比较

Tab.7 Comparison of inflammatory indicators in the mild group

组别	例数	WBC计数(×10⁹/L)				CRP(mg/L)				PCT(μg/L)
组别	例数	治疗前		治疗后		治疗前		治疗后		治疗前		治疗后
左氧氟沙星组	5	8.53±2.05		7.04±1.53		10.08±5.06		2.03±1.08		0.23±0.12		0.12±0.06
米诺环素组	15	7.08±1.85		6.04±1.58		9.06±4.58		2.53±1.27		0.19±0.09		0.09±0.05
$t$ 值		1.400		1.260		0.400		-0.860		0.680		1.010
$P$ 值		0.176		0.221		0.693		0.400		0.504		0.324
组别	LDH(U/L)				ESR(mm/h)				IL-6(ng/L)
组别	治疗前		治疗后		治疗前		治疗后		治疗前		治疗后
左氧氟沙星组	220.35±50.47		200.28±40.56		12.34±6.08		10.45±5.09		10.45±5.08		3.06±1.57
米诺环素组	210.46±45.58		190.37±35.67		11.45±5.56		9.45±4.58		9.45±4.59		3.58±1.87
$t$ 值	0.390		0.490		0.290		0.390		0.390		-0.610
$P$ 值	0.701		0.629		0.775		0.699		0.701		0.548

表7 轻症亚组炎症指标比较

Tab.7 Comparison of inflammatory indicators in the mild group

组别	例数	WBC计数(×10⁹/L)				CRP(mg/L)				PCT(μg/L)
组别	例数	治疗前		治疗后		治疗前		治疗后		治疗前		治疗后
左氧氟沙星组	5	8.53±2.05		7.04±1.53		10.08±5.06		2.03±1.08		0.23±0.12		0.12±0.06
米诺环素组	15	7.08±1.85		6.04±1.58		9.06±4.58		2.53±1.27		0.19±0.09		0.09±0.05
$t$ 值		1.400		1.260		0.400		-0.860		0.680		1.010
$P$ 值		0.176		0.221		0.693		0.400		0.504		0.324
组别	LDH(U/L)				ESR(mm/h)				IL-6(ng/L)
组别	治疗前		治疗后		治疗前		治疗后		治疗前		治疗后
左氧氟沙星组	220.35±50.47		200.28±40.56		12.34±6.08		10.45±5.09		10.45±5.08		3.06±1.57
米诺环素组	210.46±45.58		190.37±35.67		11.45±5.56		9.45±4.58		9.45±4.59		3.58±1.87
$t$ 值	0.390		0.490		0.290		0.390		0.390		-0.610
$P$ 值	0.701		0.629		0.775		0.699		0.701		0.548

表8 中症亚组炎症指标比较

Tab.8 Comparison of inflammatory indicators in the moderate group

组别	例数	WBC计数(×10⁹/L)				CRP(mg/L)				PCT(μg/L)
组别	例数	治疗前		治疗后		治疗前		治疗后		治疗前		治疗后
左氧氟沙星组	52	7.56±2.58		6.55±2.06		15.07±8.09		3.04±1.56		0.27±0.16		0.13±0.07
米诺环素组	108	7.86±2.87		6.85±2.28		14.09±7.56		3.58±1.86		0.24±0.13		0.12±0.06
$t$ 值		-0.660		-0.830		0.730		-1.920		1.180		0.880
$P$ 值		0.510		0.408		0.466		0.056		0.240		0.380
组别	LDH(U/L)				ESR(mm/h)				IL-6(ng/L)
组别	治疗前		治疗后		治疗前		治疗后		治疗前		治疗后
左氧氟沙星组	240.56±60.78		210.45±50.67		15.56±8.07		12.45±6.06		12.56±6.09		4.08±2.07
米诺环素组	230.67±55.78		205.56±45.89		14.56±7.59		11.56±5.58		11.56±5.58		4.59±2.29
$t$ 值	0.990		0.590		0.750		0.890		1.000		-1.410
$P$ 值	0.324		0.556		0.454		0.374		0.319		0.160

表8 中症亚组炎症指标比较

Tab.8 Comparison of inflammatory indicators in the moderate group

组别	例数	WBC计数(×10⁹/L)				CRP(mg/L)				PCT(μg/L)
组别	例数	治疗前		治疗后		治疗前		治疗后		治疗前		治疗后
左氧氟沙星组	52	7.56±2.58		6.55±2.06		15.07±8.09		3.04±1.56		0.27±0.16		0.13±0.07
米诺环素组	108	7.86±2.87		6.85±2.28		14.09±7.56		3.58±1.86		0.24±0.13		0.12±0.06
$t$ 值		-0.660		-0.830		0.730		-1.920		1.180		0.880
$P$ 值		0.510		0.408		0.466		0.056		0.240		0.380
组别	LDH(U/L)				ESR(mm/h)				IL-6(ng/L)
组别	治疗前		治疗后		治疗前		治疗后		治疗前		治疗后
左氧氟沙星组	240.56±60.78		210.45±50.67		15.56±8.07		12.45±6.06		12.56±6.09		4.08±2.07
米诺环素组	230.67±55.78		205.56±45.89		14.56±7.59		11.56±5.58		11.56±5.58		4.59±2.29
$t$ 值	0.990		0.590		0.750		0.890		1.000		-1.410
$P$ 值	0.324		0.556		0.454		0.374		0.319		0.160

表9 重症亚组炎症指标比较

Tab.9 Comparison of inflammatory indicators in the critical group

组别	例数	WBC计数(×10⁹/L)				CRP(mg/L)				PCT(μg/L)
组别	例数	治疗前		治疗后		治疗前		治疗后		治疗前		治疗后
左氧氟沙星组	8	9.08±3.09		7.59±2.57		20.05±10.07		4.03±2.08		0.32±0.21		0.16±0.09
米诺环素组	16	8.59±3.26		7.28±2.89		18.07±9.08		4.56±2.27		0.29±0.19		0.15±0.08
$t$ 值		0.360		0.270		0.470		-0.570		0.340		0.270
$P$ 值		0.723		0.790		0.644		0.573		0.737		0.790
组别	LDH(U/L)				ESR(mm/h)				IL-6(ng/L)
组别	治疗前		治疗后		治疗前		治疗后		治疗前		治疗后
左氧氟沙星组	260.89±70.91		230.78±60.82		18.78±10.09		14.56±7.08		15.67±8.09		5.01±2.58
米诺环素组	250.89±65.91		220.78±55.82		13.67±6.59		17.67±9.08		14.67±7.09		6.38±2.89
$t$ 值	0.330		0.390		1.300		-0.920		0.300		-0.420
$P$ 值	0.743		0.701		0.206		0.367		0.767		0.073

表9 重症亚组炎症指标比较

Tab.9 Comparison of inflammatory indicators in the critical group

组别	例数	WBC计数(×10⁹/L)				CRP(mg/L)				PCT(μg/L)
组别	例数	治疗前		治疗后		治疗前		治疗后		治疗前		治疗后
左氧氟沙星组	8	9.08±3.09		7.59±2.57		20.05±10.07		4.03±2.08		0.32±0.21		0.16±0.09
米诺环素组	16	8.59±3.26		7.28±2.89		18.07±9.08		4.56±2.27		0.29±0.19		0.15±0.08
$t$ 值		0.360		0.270		0.470		-0.570		0.340		0.270
$P$ 值		0.723		0.790		0.644		0.573		0.737		0.790
组别	LDH(U/L)				ESR(mm/h)				IL-6(ng/L)
组别	治疗前		治疗后		治疗前		治疗后		治疗前		治疗后
左氧氟沙星组	260.89±70.91		230.78±60.82		18.78±10.09		14.56±7.08		15.67±8.09		5.01±2.58
米诺环素组	250.89±65.91		220.78±55.82		13.67±6.59		17.67±9.08		14.67±7.09		6.38±2.89
$t$ 值	0.330		0.390		1.300		-0.920		0.300		-0.420
$P$ 值	0.743		0.701		0.206		0.367		0.767		0.073

表10 轻症亚组康复指标比较

Tab.10 Comparison of rehabilitation indicators in the mild group

组别	例数	体温恢复(d)	咳嗽缓解(d)	喘息缓解(d)	水泡音消失(d)	住院天数(d)	影像学改善(d)
左氧氟沙星组	5	1.23±0.35	1.14±0.46	2.45±0.58	3.56±1.67	6.78±0.89	7.56±1.34
米诺环素组	15	1.18±0.42	1.27±0.53	2.23±0.67	3.24±1.45	5.67±0.92	7.89±1.56
$t$ 值		0.280	-0.620	0.890	0.540	1.230	-0.480
$P$ 值		0.781	0.542	0.385	0.595	0.228	0.636

表10 轻症亚组康复指标比较

Tab.10 Comparison of rehabilitation indicators in the mild group

组别	例数	体温恢复(d)	咳嗽缓解(d)	喘息缓解(d)	水泡音消失(d)	住院天数(d)	影像学改善(d)
左氧氟沙星组	5	1.23±0.35	1.14±0.46	2.45±0.58	3.56±1.67	6.78±0.89	7.56±1.34
米诺环素组	15	1.18±0.42	1.27±0.53	2.23±0.67	3.24±1.45	5.67±0.92	7.89±1.56
$t$ 值		0.280	-0.620	0.890	0.540	1.230	-0.480
$P$ 值		0.781	0.542	0.385	0.595	0.228	0.636

表11 中症亚组康复指标比较

Tab.11 Comparison of rehabilitation indicators in the moderate group

组别	例数	体温恢复(d)	咳嗽缓解(d)	喘息缓解(d)	水泡音消失(d)	住院天数(d)	影像学改善(d)
左氧氟沙星组	52	1.56±0.67	2.15±0.89	3.23±1.28	4.78±2.56	9.34±2.15	9.23±2.11
米诺环素组	108	1.35±0.73	1.89±0.84	2.95±1.34	3.89±2.23	7.56±1.78	9.08±2.05
$t$ 值		1.470	1.730	1.120	1.890	1.980	0.380
$P$ 值		0.144	0.086	0.265	0.062	0.051	0.705

表11 中症亚组康复指标比较

Tab.11 Comparison of rehabilitation indicators in the moderate group

组别	例数	体温恢复(d)	咳嗽缓解(d)	喘息缓解(d)	水泡音消失(d)	住院天数(d)	影像学改善(d)
左氧氟沙星组	52	1.56±0.67	2.15±0.89	3.23±1.28	4.78±2.56	9.34±2.15	9.23±2.11
米诺环素组	108	1.35±0.73	1.89±0.84	2.95±1.34	3.89±2.23	7.56±1.78	9.08±2.05
$t$ 值		1.470	1.730	1.120	1.890	1.980	0.380
$P$ 值		0.144	0.086	0.265	0.062	0.051	0.705

表12 重症亚组康复相关指标比较

Tab.12 Comparison of rehabilitation indicators in the critical group

组别	例数	体温恢复(d)	咳嗽缓解(d)	喘息缓解(d)	水泡音消失(d)	住院天数(d)	影像学改善(d)
左氧氟沙星组	8	1.38±0.49	2.36±0.68	3.45±1.34	5.89±1.87	10.56±2.58	10.45±2.56
米诺环素组	16	1.26±0.51	2.12±0.93	2.68±1.12	4.25±1.78	6.89±1.45	10.12±2.34
$t$ 值		-0.650	0.710	1.580	2.320	2.010	0.360
$P$ 值		0.521	0.485	0.128	0.029	0.056	0.722

表12 重症亚组康复相关指标比较

Tab.12 Comparison of rehabilitation indicators in the critical group

组别	例数	体温恢复(d)	咳嗽缓解(d)	喘息缓解(d)	水泡音消失(d)	住院天数(d)	影像学改善(d)
左氧氟沙星组	8	1.38±0.49	2.36±0.68	3.45±1.34	5.89±1.87	10.56±2.58	10.45±2.56
米诺环素组	16	1.26±0.51	2.12±0.93	2.68±1.12	4.25±1.78	6.89±1.45	10.12±2.34
$t$ 值		-0.650	0.710	1.580	2.320	2.010	0.360
$P$ 值		0.521	0.485	0.128	0.029	0.056	0.722

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