铁死亡相关通路及其在癫痫中的研究进展

doi:10.3969/j.issn.1004-583X.2026.01.016

摘要/Abstract

摘要：

癫痫是一种持久性、以发作倾向为特征的神经系统慢性疾病,不仅可致患者脑损伤,亦可使患者出现神经精神症状,甚至导致神经元非可逆性死亡。积极探寻新的靶向治疗及癫痫发病的分子机制愈发重要。近年来,铁死亡参与癫痫起病的研究逐渐受到关注。研究证实,铁死亡抑制剂对减缓癫痫发作及保护神经元均有一定疗效,提示铁死亡抑制剂可能是癫痫治疗的又一新前景。基于此,本文对铁代谢、铁死亡发生、铁死亡相关通路及铁死亡在癫痫发病机制与治疗中的作用进行了综述,旨在为癫痫诊疗提供新的策略。

关键词: 癫痫, 铁死亡, 活性氧自由基, 铁死亡抑制剂

中图分类号:

R742.1

唐漆, 秦臻. 铁死亡相关通路及其在癫痫中的研究进展[J]. 临床荟萃, 2026, 41(1): 91-95.

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https://www.lchc.cn/CN/Y2026/V41/I1/91

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参考文献 34

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铁死亡相关通路及其在癫痫中的研究进展

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