关键词: 肺肿瘤, 放化疗, 焦虑情绪, 抑郁情绪, 危险因素

Abstract:

Objective To analyze the risk factors for comorbid anxiety and depression and for a single emotional disorder in patients with lung cancer receiving chemoradiotherapy.Methods A total of 108 patients with lung cancer who underwent chemoradiotherapy at Luohe Central Hospital from September 2022 to September 2025 were enrolled. Sociodemographic data, clinical characteristics, treatment-related factors, and psychological and social factors were collected. Anxiety and depression were assessed 2 weeks after chemoradiotherapy. Patients with both anxiety and depression symptoms were assigned to the comorbidity group (n=42), those with only one emotional symptom were assigned to the single-symptom group (n=40), and the remaining patients were assigned to the asymptomatic group (n=26). Multinomial logistic regression was used to identify independent risk factors for emotional disorders.Results There were 42 patients with comorbid anxiety and depression, 40 patients with either anxiety or depression alone, and 26 asymptomatic patients. Significant differences were observed among the three groups in educational level, personal monthly income, clinical stage, perceived social support scale (PSSS) score, adverse reaction grade, and Pittsburgh sleep quality index (PSQI) score (P<0.05). Logistic regression analysis showed that personal monthly income <3 000 yuan, clinical stage Ⅲ-Ⅳ, PSSS score <40, and PSQI score >7 were independent risk factors for single emotional disorder in patients with lung cancer receiving chemoradiotherapy (P<0.05). Personal monthly income <3 000 yuan, clinical stage Ⅲ-Ⅳ, PSSS score <40, adverse reaction grade 3-4, and PSQI score >7 were independent risk factors for comorbid anxiety and depression (P<0.05). Conclusion Lower personal monthly income, advanced clinical stage, low social support, more severe adverse reactions, and sleep disturbance are risk factors for comorbid anxiety and depression in patients with lung cancer receiving chemoradiotherapy. Early identification of high-risk patients and comprehensive interventions are needed to improve both physical and mental health.

Key words: lung neoplasms, chemoradiotherapy, anxiety, depression, risk factors