卒中后疲劳的研究进展

doi:10.3969/j.issn.1004-583X.2025.11.014

摘要/Abstract

摘要：

随着卒中后疲劳逐渐受到关注,它被认为是影响卒中患者康复的重要原因。卒中后疲劳不仅影响患者的生活质量,还对卒中患者的功能恢复造成了影响。本文总结了近年来卒中后疲劳的研究新进展,旨在为卒中后疲劳患者的早期诊断和干预提供依据。

关键词: 中风, 疲劳, 影响因素, 治疗

中图分类号:

R256.62

孙楠, 唐亚赛, 杨凯琦, 谢小华, 吕佩源, 董艳红. 卒中后疲劳的研究进展[J]. 临床荟萃, 2025, 40(11): 1047-1051.

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链接本文: https://www.lchc.cn/CN/10.3969/j.issn.1004-583X.2025.11.014

https://www.lchc.cn/CN/Y2025/V40/I11/1047

参考文献 35

[1]	Su Y, Yuki M, Otsuki M. Non-pharmacological interventions for post-stroke fatigue: Systematic review and network meta-analysis[J]. J Clin Med, 2020, 9(3).doi:10.3390/jcm9030621.
[2]	Huhtakangas JK, Saaresranta T, Huhtakangas M, et al. Thrombolysis treatment protected impairment of functional ability, quality of life and fatigue seven years after stroke[J]. J Stroke Cerebrovasc Dis, 2024, 33(6): 107707.doi:10.1016/j.jstrokecerebrovasdis.2024.107707.
[3]	Wu L, Jin H. A systematic review of post-stroke fatigue measurement scale based on cos min guidelines[J]. Front Neurol, 2024, 15: 1411472.doi:10.3389/fneur.2024.1411472.
[4]	Fallah S, Parnain Z, Taghavi-Azar-Sharabiani P, et al. The minimal clinically important difference of two multifaceted fatigue evaluation questionnaires in chronic stroke[J]. Top Stroke Rehabil, 2024: 1-14.doi:10.1080/10749357.2024.2408997.
[5]	Ren W, Wang M, Wang Q, et al. Altered functional connectivity in patients with post-stroke fatigue: A resting-state fmri study[J]. J Affect Disord, 2024, 350: 468-475.doi:10.1016/j.jad.2024.01.129.
[6]	Mutai H, Furukawa T, Houri A, et al. Factors associated with multidimensional aspect of post-stroke fatigue in acute stroke period[J]. Asian J Psychiatr, 2017, 26: 1-5.doi:10.1016/j.ajp.2016.12.015. pmid: 28483068
[7]	Kindred JH, Gregory CM, Kautz SA, et al. Interhemispheric asymmetries in intracortical facilitation correlate with fatigue severity in individuals with poststroke fatigue[J]. J Clin Neurophysiol, 2024, 41(4): 365-372.doi:10.1097/wnp.0000000000000994.
[8]	Shu J, Ren Y, Liu G, et al. Association between stroke characteristics and post-stroke fatigue: A meta-analysis[J]. Neurol India, 2022, 70(2): 676-681.doi:10.4103/0028-3886.344612. pmid: 35532638
[9]	Gyawali P, Hinwood M, Chow WZ, et al. Exploring the relationship between fatigue and circulating levels of the pro-inflammatory biomarkers interleukin-6 and c-reactive protein in the chronic stage of stroke recovery: A cross-sectional study[J]. Brain Behav Immun Health, 2020, 9: 100157.doi:10.1016/j.bbih.2020.100157.
[10]	任思强, 张茜, 代玉玺, 等. 脑卒中后疲劳发病机制及影响因素的研究进展[J]. 临床神经病学杂志, 2021, 34(3): 223-226.doi:Cnki:Sun:Lcsj.0.2021-03-030.
[11]	Scopelliti G, Rossi C, Kuchcinski G, et al. Fatigue after spontaneous intracerebral haemorrhage: Prevalence and associated factors[J]. Neurol Sci, 2024, 45(5): 2127-2135.doi:10.1007/s10072-023-07196-8.
[12]	Becker CJ, Lisabeth LD, Kwicklis M, et al. Association between sleep-disordered breathing and post-stroke fatigue in patients with ischemic stroke[J]. J Stroke Cerebrovasc Dis, 2024, 33(6): 107701.doi:10.1016/j.jstrokecerebrovasdis.2024.107701.
[13]	García-Bouyssou I, Laredo C, Massons M, et al. Clinical and neuroanatomical predictors of post-stroke fatigue[J]. J Stroke Cerebrovasc Dis, 2024, 33(6): 107708.doi:10.1016/j.jstrokecerebrovasdis.2024.107708.
[14]	Ouyang Q, Xu L, Zhang Y, et al. Relationship between glycated hemoglobin levels at admission and chronic post-stroke fatigue in patients with acute ischemic stroke[J]. Exp Gerontol, 2024, 188: 112395.doi:10.1016/j.exger.2024.112395.
[15]	Schnitzer L, Hansson PO, Samuelsson CM, et al. Fatigue in stroke survivors: A 5-year follow-up of the fall study of gothenburg[J]. J Neurol, 2023, 270(10): 4812-4819.doi:10.1007/s00415-023-11812-0. pmid: 37318549
[16]	貌雯靖, 罗颖, 詹杰, 等. 脑卒中后疲劳严重程度的影响因素分析[J]. 中西医结合心脑血管病杂志, 2024, 22(9): 1675-1677.doi:10.12102/j.issn.1672-1349.2024.09.027.
[17]	Klinedinst NJ, Schuh R, Kittner SJ, et al. Post-stroke fatigue as an indicator of underlying bioenergetics alterations[J]. J Bioenerg Biomembr, 2019, 51(2): 165-174.doi:10.1007/s10863-018-9782-8. pmid: 30617735
[18]	Byun E, McCurry SM, Kwon S, et al. Fatigue, toll-like receptor 4, and pro-inflammatory cytokines in adults with subarachnoid hemorrhage: A 6-month longitudinal study[J]. Biol Res Nurs, 2024, 26(2): 192-201.doi:10.1177/10998004231203257.
[19]	Koceniak P, Chatys-Bogacka Z, Slowik A, et al. Reduced ex vivo tnfα synthesis upon whole blood stimulation with endotoxin predicts post-stroke fatigue[J]. J Psychosom Res, 2023, 172: 111426.doi:10.1016/j.jpsychores.2023.111426.
[20]	Carrick C, Kusec A, Demeyere N. Post-stroke fatigue severity is associated with executive dysfunction in chronic stroke[J]. Neuropsychol Rehabil, 2024: 1-23.doi:10.1080/09602011.2024.2414864.
[21]	Bivard A, Lillicrap T, Krishnamurthy V, et al. Midas (modafinil in debilitating fatigue after stroke): A randomized, double-blind, placebo-controlled, cross-over trial[J]. Stroke, 2017, 48(5): 1293-1298.doi:10.1161/strokeaha.116.016293. pmid: 28404841
[22]	Visser MM, Goodin P, Parsons MW, et al. Modafinil treatment modulates functional connectivity in stroke survivors with severe fatigue[J]. Sci Rep, 2019, 9(1): 9660.doi:10.1038/s41598-019-46149-0. pmid: 31273283
[23]	Giovannini S, Iacovelli C, Loreti C, et al. The role of nutritional supplement on post-stroke fatigue: A pilot randomized controlled trial[J]. J Nutr Health Aging, 2024, 28(7): 100256.doi:10.1016/j.jnha.2024.100256.
[24]	Jin C, Kwon S, Cho SY, et al. A systematic review and meta-analysis of the effects of herbal medicine buyang huanwu tang in patients with poststroke fatigue[J]. Evid Based Complement Alternat Med, 2021, 2021: 4835488.doi:10.1155/2021/4835488.
[25]	武明霞, 盛茹雅, 孙冬玮, 等. 盘龙刺联合醒脑开窍针刺法治疗脑卒中后疲劳:随机对照试验[J]. 中国针灸, 2022, 42(10): 1089-1093.doi:10.13703/j.0255-2930.20211104-0002.
[26]	李静, 周冰原, 程乐, 等. 芒针透刺联合通督调神法针刺治疗卒中后疲劳:随机对照试验[J]. 中国针灸, 2024, 44(10): 1114-1118+1124.doi:10.13703/j.0255-2930.20231114-k0008.
[27]	Han X, Duan H, Hu J, et al. Acupuncture combined with traditional chinese medicine for post-stroke fatigue: A randomized controlled trial[J]. Asian J Surg, 2023, 46(11): 5310-5311.doi:10.1016/j.asjsur.2023.07.044. pmid: 37574359
[28]	Moyle DB, Kudiersky MN, Totton MN, et al. Remote ischaemic conditioning for fatigue after stroke (ricfast): A pilot randomised controlled trial[J]. J Stroke Cerebrovasc Dis, 2023, 32(12): 107420.doi:10.1016/j.jstrokecerebrovasdis.2023.107420.
[29]	De Doncker W, Ondobaka S, Kuppuswamy A. Effect of transcranial direct current stimulation on post-stroke fatigue[J]. J Neurol, 2021, 268(8): 2831-2842.doi:10.1007/s00415-021-10442-8. pmid: 33598767
[30]	Dong XL, Sun X, Sun WM, et al. A randomized controlled trial to explore the efficacy and safety of transcranial direct current stimulation on patients with post-stroke fatigue[J]. Medicine (Baltimore), 2021, 100(41): e27504.doi:10.1097/md.0000000000027504.
[31]	Nguyen S, Wong D, McKay A, et al. Cognitive behavioural therapy for post-stroke fatigue and sleep disturbance: A pilot randomised controlled trial with blind assessment[J]. Neuropsychol Rehabil, 2019, 29(5): 723-738.doi:10.1080/09602011.2017.1326945. pmid: 28521579
[32]	Ymer L, McKay A, Wong D, et al. Cognitive behavioral therapy for sleep disturbance and fatigue following acquired brain injury: Predictors of treatment response[J]. J Head Trauma Rehabil, 2022, 37(3): E220-e230.doi:10.1097/htr.0000000000000705.
[33]	Ymer L, McKay A, Wong D, et al. Cognitive behavioural therapy versus health education for sleep disturbance and fatigue after acquired brain injury: A pilot randomised trial[J]. Ann Phys Rehabil Med, 2021, 64(5): 101560.doi:10.1016/j.rehab.2021.101560.
[34]	Yoon HS, Cha YJ, You JSH. The effects of dynamic core-postural chain stabilization on respiratory function, fatigue and activities of daily living in subacute stroke patients: A randomized control trial[J]. NeuroRehabilitation, 2020, 47(4): 471-477.doi:10.3233/nre-203231. pmid: 33164956
[35]	West A, Simonsen SA, Jennum P, et al. An exploratory investigation of the effect of naturalistic light on fatigue and subjective sleep quality in stroke patients admitted for rehabilitation: A randomized controlled trial[J]. NeuroRehabilitation, 2019, 45(2): 187-200.doi:10.3233/nre-192752. pmid: 31498136

卒中后疲劳的研究进展

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