临床荟萃 ›› 2025, Vol. 40 ›› Issue (8): 748-752.doi: 10.3969/j.issn.1004-583X.2025.08.014
孙楠1,2,3, 杨凯琦2,3,4, 唐亚赛2,3,5, 谢小华2,3, 吕佩源2,3, 董艳红2,3(
)
收稿日期:2025-06-05
出版日期:2025-08-20
发布日期:2025-09-05
通讯作者:
董艳红
E-mail:d_yanhongniu@163.com
基金资助:
Received:2025-06-05
Online:2025-08-20
Published:2025-09-05
摘要：
帕金森病(Parkinson disease, PD)是临床常见的神经系统变性疾病,认知障碍是其常见的非运动症状。PD认知障碍治疗是综合多学科的治疗。本文对目前PD认知障碍治疗新进展进行综述。
中图分类号:
孙楠, 杨凯琦, 唐亚赛, 谢小华, 吕佩源, 董艳红. 帕金森病认知障碍的治疗新进展[J]. 临床荟萃, 2025, 40(8): 748-752.
| [1] |
Aarsland D, Creese B, Politis M, et al. Cognitive decline in parkinson disease[J]. Nat Rev Neurol, 2017, 13(4): 217-231.
doi: 10.1038/nrneurol.2017.27 pmid: 28257128 |
| [2] |
Shanbhag NM, Padmanabhan JL, Zhang Z, et al. An acetylcholine m1 receptor-positive allosteric modulator (tak-071) in parkinson disease with cognitive impairment: A phase 2 randomized clinical trial[J]. JAMA Neurol, 2025, 82(2): 152-159.
doi: 10.1001/jamaneurol.2024.4519 pmid: 39761063 |
| [3] | Xu D, Fang Y, Hu M, et al. The efficacy of levodopa/carbidopa/entacapone on cognitive function in moderate to advanced parkinson's disease and its relationship with peripheral inflammatory cytokines[J]. BMC Neurol, 2025, 25(1): 116. |
| [4] |
Suzuki K, Funakoshi K, Fujita H, et al. The effect of rotigotine on cognitive function, daytime sleepiness, and sleep problems in parkinson disease: An open-label pilot study[J]. Clin Neuropharmacol, 2022, 45(3): 61-64.
doi: 10.1097/WNF.0000000000000501 pmid: 35579485 |
| [5] | Yulug B, Altay O, Li X, et al. Multi-omics characterization of improved cognitive functions in parkinson's disease patients after the combined metabolic activator treatment: A randomized, double-blinded, placebo-controlled phase ii trial[J]. Brain Commun, 2025, 7(1): fcae478. |
| [6] |
Zhang H, Hao Y, Manor B, et al. Intranasal insulin enhanced resting-state functional connectivity of hippocampal regions in type 2 diabetes[J]. Diabetes, 2015, 64(3): 1025-1034.
doi: 10.2337/db14-1000 pmid: 25249577 |
| [7] | Novak P, Pimentel Maldonado DA, Novak V. Safety and preliminary efficacy of intranasal insulin for cognitive impairment in parkinson disease and multiple system atrophy: A double-blinded placebo-controlled pilot study[J]. PLoS One, 2019, 14(4): e0214364. |
| [8] |
Fang C, Hernandez P, Liow K, et al. Buntanetap, a novel translational inhibitor of multiple neurotoxic proteins, proves to be safe and promising in both alzheimer's and parkinson's patients[J]. J Prev Alzheimers Dis, 2023, 10(1): 25-33.
doi: 10.14283/jpad.2022.84 pmid: 36641607 |
| [9] | Mitarnun W, Kanjanarangsichai A, Junlaor P, et al. Cannabidiol and cognitive functions/inflammatory markers in parkinson's disease: A double-blind randomized controlled trial at buriram hospital (cbd-pd-brh trial)[J]. Parkinsonism Relat Disord, 2025, 135: 107841. |
| [10] |
Bueno MEB, do Nascimento Neto LI, Terra MB, et al. Effectiveness of acute transcranial direct current stimulation on non-motor and motor symptoms in parkinson's disease[J]. Neurosci Lett, 2019, 696: 46-51.
doi: S0304-3940(18)30862-0 pmid: 30553865 |
| [11] | Del Felice A, Castiglia L, Formaggio E, et al. Personalized transcranial alternating current stimulation (tacs) and physical therapy to treat motor and cognitive symptoms in parkinson's disease: A randomized cross-over trial[J]. Neuroimage Clin, 2019, 22: 101768. |
| [12] | He W, Wang JC, Tsai PY. Theta burst magnetic stimulation improves parkinson's-related cognitive impairment: A randomised controlled study[J]. Neurorehabil Neural Repair, 2021, 35(11): 986-995. |
| [13] |
Brandt T, Schautzer F, Hamilton DA, et al. Vestibular loss causes hippocampal atrophy and impaired spatial memory in humans[J]. Brain, 2005, 128(Pt 11): 2732-2741.
doi: 10.1093/brain/awh617 pmid: 16141283 |
| [14] | Kumar Goothy SS, Gawarikar S, Choudhary A, et al. Effectiveness of electrical vestibular nerve stimulation as adjunctive therapy to improve the cognitive functions in patients with parkinson's disease[J]. J Basic Clin Physiol Pharmacol, 2023, 34(1): 77-82. |
| [15] |
De Luca R, Latella D, Maggio MG, et al. Computer assisted cognitive rehabilitation improves visuospatial and executive functions in parkinson's disease: Preliminary results[J]. NeuroRehabilitation, 2019, 45(2): 285-290.
doi: 10.3233/NRE-192789 pmid: 31498141 |
| [16] | Sawada H, Oeda T, Kohsaka M, et al. Early-start vs delayed-start donepezil against cognitive decline in parkinson disease: A randomized clinical trial[J]. Expert Opin Pharmacother, 2021, 22(3): 363-371. |
| [17] | Ophey A, Giehl K, Rehberg S, et al. Effects of working memory training in patients with parkinson's disease without cognitive impairment: A randomized controlled trial[J]. Parkinsonism Relat Disord, 2020, 72: 13-22. |
| [18] | van de Weijer SCF, Duits AA, Bloem BR, et al. Feasibility of a cognitive training game in parkinson's disease: The randomized parkin'play study[J]. Eur Neurol, 2020, 83(4): 426-432. |
| [19] |
Picelli A, Varalta V, Melotti C, et al. Effects of treadmill training on cognitive and motor features of patients with mild to moderate parkinson's disease: A pilot, single-blind, randomized controlled trial[J]. Funct Neurol, 2016, 31(1): 25-31.
pmid: 27027891 |
| [20] |
Vilela TC, Muller AP, Damiani AP, et al. Strength and aerobic exercises improve spatial memory in aging rats through stimulating distinct neuroplasticity mechanisms[J]. Mol Neurobiol, 2017, 54(10): 7928-7937.
doi: 10.1007/s12035-016-0272-x pmid: 27878552 |
| [21] | Johansson ME, Cameron IGM, Van der Kolk NM, et al. Aerobic exercise alters brain function and structure in parkinson's disease: A randomized controlled trial[J]. Ann Neurol, 2022, 91(2): 203-216. |
| [22] | Tsai CL, Chien CY, Pan CY, et al. Effects of long-term tai chi vs. Aerobic exercise on antioxidant activity and cognitive function in individuals with parkinson's disease[J]. Behav Brain Res, 2025, 476: 115274. |
| [23] | Li G, Huang P, Cui S, et al. Tai chi improves non-motor symptoms of parkinson's disease: One-year randomized controlled study with the investigation of mechanisms[J]. Parkinsonism Relat Disord, 2024, 120: 105978. |
| [24] | Gobbi LTB, Pelicioni PHS, Lahr J, et al. Effect of different types of exercises on psychological and cognitive features in people with parkinson's disease: A randomized controlled trial[J]. Ann Phys Rehabil Med, 2021, 64(1):101407. |
| [25] |
Yan Y, Xu Y, Wang X, et al. The effect of multi-component exercise intervention in older people with parkinson's disease and mild cognitive impairment: A randomized controlled study[J]. Geriatr Nurs, 2024, 60: 137-145.
doi: 10.1016/j.gerinurse.2024.08.028 pmid: 39244799 |
| [26] | Moon S, Sarmento CVM, Steinbacher M, et al. Can qigong improve non-motor symptoms in people with parkinson's disease-a pilot randomized controlled trial?[J]. Complement Ther Clin Pract, 2020, 39:101169. |
| [27] | Pereira-Pedro KP, de Oliveira IM, Mollinedo-Cardalda I, et al. Effects of cycling dual-task on cognitive and physical function in parkinson's disease: A randomized double-blind pilot study[J]. Int J Environ Res Public Health, 2022, 19(13):7847. |
| [28] | Yang YR, Cheng SJ, Lee YJ, et al. Cognitive and motor dual task gait training exerted specific training effects on dual task gait performance in individuals with parkinson's disease: A randomized controlled pilot study[J]. PLoS One, 2019, 14(6): e0218180. |
| [29] | Lin YP Lin, II, Chiou WD, et al. Optimizing rehabilitation strategies in parkinson's disease: A comparison of dual cognitive-walking treadmill training and single treadmill training[J]. Sci Rep, 2024, 14(1): 25210. |
| [30] |
Leocadi M, Canu E, Sarasso E, et al. Dual-task gait training improves cognition and resting-state functional connectivity in parkinson's disease with postural instability and gait disorders[J]. J Neurol, 2024, 271(4): 2031-2041.
doi: 10.1007/s00415-023-12151-w pmid: 38189921 |
| [31] | San Martín Valenzuela C, Moscardó LD, López-Pascual J, et al. Effects of dual-task group training on gait, cognitive executive function, and quality of life in people with parkinson disease: Results of randomized controlled dualgait trial[J]. Arch Phys Med Rehabil, 2020, 101(11): 1849-1856.e1841. |
| [32] | Silva-Batista C, Almeida FO, Batista A, et al. Complex exercises improve cognition in people with parkinson's disease and freezing of gait[J]. Neurorehabil Neural Repair, 2025, 39(1): 3-15. |
| [33] | Cucca A, Di Rocco A, Acosta I, et al. Art therapy for parkinson's disease[J]. Parkinsonism Relat Disord, 2021, 84: 148-154. |
| [34] |
Kalyani HHN, Sullivan KA, Moyle G, et al. Impacts of dance on cognition, psychological symptoms and quality of life in parkinson's disease[J]. NeuroRehabilitation, 2019, 45(2): 273-283.
doi: 10.3233/NRE-192788 pmid: 31561398 |
| [35] | Mao H, Li Y, Tang L, et al. Effects of mirror neuron system-based training on rehabilitation of stroke patients[J]. Brain Behav, 2020, 10(8): e01729. |
| [36] | Maggio MG, De Cola MC, Latella D, et al. What about the role of virtual reality in parkinson disease's cognitive rehabilitation? Preliminary findings from a randomized clinical trial[J]. J Geriatr Psychiatry Neurol, 2018, 31(6): 312-318. |
| [37] | Cheng TC, Huang SF, Wu SY, et al. Integration of virtual reality into transcranial magnetic stimulation improves cognitive function in patients with parkinson's disease with cognitive impairment: A proof-of-concept study[J]. J Parkinsons Dis, 2022, 12(2): 723-736. |
| [38] | Maggio MG, Luca A, Cicero CE, et al. Effectiveness of telerehabilitation plus virtual reality (tele-rv) in cognitive e social functioning: A randomized clinical study on parkinson's disease[J]. Parkinsonism Relat Disord, 2024, 119: 105970. |
| [39] | Fiorenzato E, Zabberoni S, De Simone MS, et al. Effects of virtual reality cognitive training on executive function and prospective memory in parkinson's disease and healthy aging[J]. J Neurol Sci, 2025, 473: 123507. |
| [40] | Latella D, Maggio MG, Maresca G, et al. Effects of domotics on cognitive, social and personal functioning in patients with parkinson's disease: A pilot study[J]. Assist Technol, 2022, 34(4): 423-428. |
| [41] | Kraepelien M, Schibbye R, Månsson K, et al. Individually tailored internet-based cognitive-behavioral therapy for daily functioning in patients with parkinson's disease: A randomized controlled trial[J]. J Parkinsons Dis, 2020, 10(2): 653-664. |
| [1] | 赵伟, 徐慧娟, 赵艳霞, 王玲珍, 卢愿, 杨静. 婴儿恶性石骨症1例并文献复习[J]. 临床荟萃, 2025, 40(8): 726-730. |
| [2] | 陈文江, 舒展, 周来显. 基于核酸适配体的肺癌诊断和治疗研究进展[J]. 临床荟萃, 2025, 40(8): 742-747. |
| [3] | 武媛媛, 孟舰. 代谢重编程在脓毒症相关急性肾损伤中的研究进展[J]. 临床荟萃, 2025, 40(8): 753-757. |
| [4] | 卢远思, 吕见君, 官计彬, 操龙斌. 双相情感障碍患者外周血中FGF1的表达与糖脂代谢的相关性[J]. 临床荟萃, 2025, 40(7): 619-623. |
| [5] | 孙振晓, 于相芬. 皮肤搔抓障碍的研究进展[J]. 临床荟萃, 2025, 40(7): 647-652. |
| [6] | 毛静静, 兰云霞, 陈鲁玉, 宋先荣. A型主动脉夹层合并肠系膜上动脉缺血的研究进展[J]. 临床荟萃, 2025, 40(7): 659-662. |
| [7] | 林彬城, 林刚曦. 病因、术前病程对药物难治性癫痫患儿疗效的影响[J]. 临床荟萃, 2025, 40(6): 527-531. |
| [8] | 王思晗, 李向红, 李亮亮, 锡洪敏, 杨萍, 马丽丽, 尹向云. 新生儿RYR1相关肌病1例并文献复习[J]. 临床荟萃, 2025, 40(6): 541-546. |
| [9] | 孙振晓, 于相芬. 幻肢痛的临床治疗进展[J]. 临床荟萃, 2025, 40(6): 570-576. |
| [10] | 刘萍, 于猛, 刘明新, 李文锋. 血常规衍生的新型炎症指标与急性前壁ST段抬高型心肌梗死患者PCI术后院内发生不良心血管事件的相关性[J]. 临床荟萃, 2025, 40(5): 400-407. |
| [11] | 赵雅静, 陶千山, 沈元元, 董毅. 地西他滨维持治疗对适合强化疗中低危急性髓细胞白血病患者生存的影响[J]. 临床荟萃, 2025, 40(5): 439-444. |
| [12] | 范玉雯, 宋佳, 黄盼娜, 张晓岚. 淋巴细胞归巢在炎症性肠病中的作用及相关治疗靶点[J]. 临床荟萃, 2025, 40(5): 468-472. |
| [13] | 赵世亮, 牛艳国, 赵燕民, 李俊青, 洪丽, 王献. 颅内动脉瘤介入术后认知功能障碍的因素探讨:基于PSM法[J]. 临床荟萃, 2025, 40(4): 320-324. |
| [14] | 苏淼, 王飒爽, 赵东强. 《中国肥胖症消化内镜治疗专家共识》解读[J]. 临床荟萃, 2025, 40(4): 366-371. |
| [15] | 黄兴舟, 郑卫华, 张树桐, 陈燕浩. 载药微球与常规支气管动脉化疗栓塞术治疗晚期非小细胞肺癌的临床疗效及安全性对比[J]. 临床荟萃, 2025, 40(3): 243-250. |
| 阅读次数 | ||||||
|
全文 |
|
|||||
|
摘要 |
|
|||||
