关键词: 骨化二醇, 血脂, 尿酸

Abstract:

Objective To examine the relationship between serum 25-hydroxyvitamin D₃ [25(OH)D₃] levels and lipid parameters as well as uric acid (UA) among middle-aged and elderly men in Chengdu. Methods In this cross-sectional study, 400 men (age ≥45) who visited Chengdu Second People's Hospital from January to December 2025 were enrolled. Fasting serum levels of 25(OH)D₃, triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and UA were measured. Subjects were classified by 25(OH)D₃ concentration: deficiency (<12 ng/ml), insufficiency (12-20 ng/ml), and sufficient (≥20 ng/ml). Spearman rank correlation assessed associations between 25(OH)D₃ and metabolic indicators. Binary logistic regression evaluated the association of 25(OH)D₃ with dyslipidemia and hyperuricemia. Results The combined prevalence of vitamin D insufficiency or deficiency was 34.7%. LDL-C, TC, and HDL-C differed significantly across vitamin D status groups (all P<0.05). Spearman analysis showed a positive correlation between serum 25(OH)D₃ and HDL-C (r=0.153, P<0.05), and negative correlations with LDL-C (r=-0.839) and TC(r=-0.840) (both P<0.05). No significant correlations were observed between 25(OH)D₃ and TG (P=0.059) or UA (P=0.406). In binary logistic regression, higher serum 25(OH)D₃ was associated with a lower odds of hypercholesterolemia (OR=0.975, 95%CI: 0.955-0.997, P=0.025), but showed no significant association with hyperuricemia (OR=1.017, 95%CI: 0.996-1.038, P=0.115). Conclusion A considerable portion of middle-aged and elderly men in Chengdu exhibit vitamin D insufficiency or deficiency. Serum 25(OH)D₃ is significantly associated with key lipid measures (HDL-C, LDL-C, TC), indicating a relationship between vitamin D status and lipid metabolism; however, no significant link with uric acid metabolism was detected.

Key words: calcifediol, blood lipids, uric acid