关键词: 肾透析, 甲状旁腺功能亢进症, 继发性, 甲状旁腺切除术, 睡眠

Abstract: Objective  The maintenance hemodialysis patients with parathyroidectomy were followed up to investigate the effects of parathyroid adenectomy on the quality of sleep.Methods  Sixteen hemodialysis patients were selected for parathyroidectomy due to secondary hyperparathyroidism.Followup was performed one month before and one year after surgery.The changes in Ca， P， and parathyroid hormone were observed before and after surgery.Pittsburgh Sleep Index (PSIQ) was used to assess the quality of sleep before and after surgery.Results  One year after parathyroidectomy， the quality of sleep was significantly improved（PSQI 17.48±5.13 vs 3.17±2.63，P<0.05）.The number of patients with bone pain and itchy symptoms also decreased significantly.Blood calcium， phosphorus and  iPTH levels also decreased significantly. Conclusion  Parathyroid hormone level plays a critical role in the sleep problems of patients with maintenance hemodialysis. Parathyroidectomy can significantly improve the quality of sleep in maintenance hemodialysis patients.It could improve the sleep quality and prognosis of patients， and promote the reintegration of patients with uremia.

Key words: renal dialysis, hyperparathyroidism, secondary, parathyroidectomy, sleep