胰高血糖素样肽-1受体基因多态性的研究进展

doi:10.3969/j.issn.1004-583X.2025.01.015

摘要/Abstract

摘要：

胰高血糖素样肽-1受体(glucagon-like peptide-1 receptor,GLP-1R)与胰高血糖素样肽-1特异性结合,参与激素信号接收和受体激活,在不同组织中均起着重要作用。近年来研究发现,GLP-1R单核苷酸多态性与多种疾病有关,在糖代谢、脂代谢、神经精神调节和骨代谢等方面具有重要作用。本文对主要的GLP-1R单核苷酸多态性(rs6923761、rs3765467、rs1042044和rs10305420)在相关疾病发病机制中的作用进行综述,为疾病的发病机制、基因诊断筛查和治疗提供依据。

关键词: 基因, 多态性, 单核苷酸, 胰高血糖素样肽-1受体, 疾病

中图分类号:

R394.33

刘畅, 鲍晓雪, 刘辉明, 田雅玮, 李玉坤. 胰高血糖素样肽-1受体基因多态性的研究进展[J]. 临床荟萃, 2025, 40(1): 90-96.

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链接本文: https://www.lchc.cn/CN/10.3969/j.issn.1004-583X.2025.01.015

https://www.lchc.cn/CN/Y2025/V40/I1/90

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参考文献 56

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胰高血糖素样肽-1受体基因多态性的研究进展

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