DNA甲基化与脑影像学改变在抑郁症中的研究进展——基于病理假说视角

doi:10.3969/j.issn.1004-583X.2026.05.011

临床荟萃 ›› 2026, Vol. 41 ›› Issue (5): 457-461.doi: 10.3969/j.issn.1004-583X.2026.05.011

DNA甲基化与脑影像学改变在抑郁症中的研究进展——基于病理假说视角

朱卓豪¹, 黄园园¹^,², 李荷花¹^,², 吴逢春¹^,²()

¹ 广州医科大学附属脑科医院精神科, 广东广州 510370
² 广东省精神疾病转化医学工程技术研究中心, 广东广州 510370

收稿日期:2026-02-27 出版日期:2026-05-20 发布日期:2026-05-26
通讯作者: 吴逢春,Email:13580380071@163.com
基金资助:
国家重点研发项目——耦合功能驱动的新型非植入脑机接口装备研发(2025YFC3410000); 国家重点研发项目——闭环新型脑机接口装备的多中心验证与临床应用(2025YFC3410005); 国家自然科学基金资助项目——精神分裂症认知损害的肠道谷氨酸代谢异常与前额叶Glu/GABA失衡相关性初探(82301688); 广东省自然科学基金项目——肠道谷氨酸代谢异常与额顶网络Glu/GABA失衡介导抑郁症认知损害的肠-脑关联研究(2025A1515010507); 广州市科技计划项目——首发抑郁症患者自伤与自杀行为的脑-肠耦合网络特征及差异性研究(2025A03J3357); 广州医科大学科研能力提升项目——基于肠道宏基因组学技术探索抑郁症认知损害的识别及生理机制(2024SRP200); 广州市临床重点专科(临床医学研究所)

Received:2026-02-27 Online:2026-05-20 Published:2026-05-26

摘要/Abstract

摘要：

抑郁症(major depressive disorder, MDD)是一种以情绪低落、兴趣减退和快感缺失为核心症状的情感障碍,给患者及社会带来沉重负担。MDD的发病机制复杂,遗传作为重要因素,多个基因位点的突变已被证实与MDD相关,但单个位点效应有限,无法完全解释MDD的易感性。近年来,基因—环境相互作用与MDD致病相关的研究逐渐受到关注,神经影像联合DNA甲基化研究提示环境因素可通过DNA甲基化等机制影响基因表达,从而调控脑区功能和神经网络活动并介导MDD的发生。本文基于MDD病理假说视角,综述了MDD相关基因DNA甲基化伴随的脑影像学改变,旨在为理解MDD的病理机制提供新的视角,并为疾病预测和疗效评估提供参考与策略支持。

关键词: 抑郁症, DNA甲基化, 表观基因组学, 影像基因组学, 磁共振成像

中图分类号:

R749.41

朱卓豪, 黄园园, 李荷花, 吴逢春. DNA甲基化与脑影像学改变在抑郁症中的研究进展——基于病理假说视角[J]. 临床荟萃, 2026, 41(5): 457-461.

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